|Group: TK Family: Trk |
Description: neurotrophic tyrosine kinase, receptor, type 1
Gene Symbol: NTRK1
Synonyms: DKFZp781I14186, MTC, TRK, TRK1, TRKA, p140-TrkA
UniprotKB/SwissProt: NTRK1_HUMAN (P04629)
Function: Required for high-affinity binding to nerve growth factor (NGF), neurotrophin-3 and neurotrophin-4/5 but not brain- derived neurotrophic factor (BDNF). Known substrates for the Trk receptors are SHC1, PI 3-kinase, and PLC-gamma-1. Has a crucial role in the development and function of the nociceptive reception system as well as establishment of thermal regulation via sweating. Activates ERK1 by either SHC1- or PLC-gamma-1-dependent signaling pathway.
Subcellular Localization: Cell membrane; Single-pass type I membrane protein (By similarity). Note=Endocytosed to the endosomes upon treatment of cells with NGF (By similarity).