Regulatory Network in Protein Phosphorylation
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Kinase: TRKB neurotrophic tyrosine kinase, receptor, type 2

Group: TK      Family: Trk      

Description: neurotrophic tyrosine kinase, receptor, type 2

Gene Symbol: NTRK2

Synonyms: GP145-TrkB, TRKB

UniprotKB/SwissProt: NTRK2_HUMAN (Q16620)

Function: Receptor for brain-derived neurotrophic factor (BDNF), neurotrophin-3 and neurotrophin-4/5 but not nerve growth factor (NGF). Involved in the development and/or maintenance of the nervous system. This is a tyrosine-protein kinase receptor. Known substrates for the TRK receptors are SHC1, PI-3 kinase, and PLC- gamma-1.

Subcellular Localization: Membrane; Single-pass type I membrane protein.

Protein Domain:
PDB:1HCF

The substrate proteins of kinase TRKB

No.Gene NameUniProtKB IDProtein DescriptionNumber of kinase-specific phosphorylation sitesView
1NTRK2NTRK2_HUMANBDNF/NT-3 growth factors receptor precursor (EC 2.7.10.1)(Neurotrophic tyrosine kinase receptor type 2) (TrkB tyrosine kinase)(GP145-TrkB) (Trk-B). 5Show



The substrate proteins of kinase family Trk

 No.Gene NameUniProtKB IDProtein DescriptionNumber of kinase family-specific phosphorylated sitesView
1NTRK1NTRK1_HUMANHigh affinity nerve growth factor receptor precursor (EC 2.7.10.1)(Neurotrophic tyrosine kinase receptor type 1) (TRK1-transformingtyrosine kinase protein) (p140-TrkA) (Trk-A). 7Show
2NTRK2NTRK2_HUMANBDNF/NT-3 growth factors receptor precursor (EC 2.7.10.1)(Neurotrophic tyrosine kinase receptor type 2) (TrkB tyrosine kinase)(GP145-TrkB) (Trk-B). 5Show