|Group: TK Family: Trk |
Description: neurotrophic tyrosine kinase, receptor, type 2
Gene Symbol: NTRK2
Synonyms: GP145-TrkB, TRKB
UniprotKB/SwissProt: NTRK2_HUMAN (Q16620)
Function: Receptor for brain-derived neurotrophic factor (BDNF), neurotrophin-3 and neurotrophin-4/5 but not nerve growth factor (NGF). Involved in the development and/or maintenance of the nervous system. This is a tyrosine-protein kinase receptor. Known substrates for the TRK receptors are SHC1, PI-3 kinase, and PLC- gamma-1.
Subcellular Localization: Membrane; Single-pass type I membrane protein.