Regulatory Network in Protein Phosphorylation
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Kinase: TRKC neurotrophic tyrosine kinase, receptor, type 3

Group: TK      Family: Trk      

Description: neurotrophic tyrosine kinase, receptor, type 3

Gene Symbol: NTRK3

Synonyms: TRKC, gp145(trkC)

UniprotKB/SwissProt: NTRK3_HUMAN (Q16288)

Function: Receptor for neurotrophin-3 (NT-3). This is a tyrosine- protein kinase receptor. Known substrates for the trk receptors are SHC1, PI-3 kinase, and PLCG1. The different isoforms do not have identical signaling properties.

Subcellular Localization: Membrane; Single-pass type I membrane protein.

Protein Domain:
PDB:1WWC

The substrate proteins of kinase family Trk

 No.Gene NameUniProtKB IDProtein DescriptionNumber of kinase family-specific phosphorylated sitesView
1NTRK1NTRK1_HUMANHigh affinity nerve growth factor receptor precursor (EC 2.7.10.1)(Neurotrophic tyrosine kinase receptor type 1) (TRK1-transformingtyrosine kinase protein) (p140-TrkA) (Trk-A). 7Show
2NTRK2NTRK2_HUMANBDNF/NT-3 growth factors receptor precursor (EC 2.7.10.1)(Neurotrophic tyrosine kinase receptor type 2) (TrkB tyrosine kinase)(GP145-TrkB) (Trk-B). 5Show