|Group: TK Family: VEGFR |
Description: fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor)
Gene Symbol: FLT1
Synonyms: FLT, VEGFR1
UniprotKB/SwissProt: VGFR1_HUMAN (P17948)
Function: Receptor for VEGF, VEGFB and PGF. Has a tyrosine-protein kinase activity. The VEGF-kinase ligand/receptor signaling system plays a key role in vascular development and regulation of vascular permeability. Isoform SFlt1 may have an inhibitory role in angiogenesis.
Subcellular Localization: Isoform Flt1: Cell membrane; Single-pass type I membrane protein. Isoform sFlt1: Secreted.