Regulatory Network in Protein Phosphorylation
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Kinase: FLT1 fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor)

Group: TK      Family: VEGFR      

Description: fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor)

Gene Symbol: FLT1

Synonyms: FLT, VEGFR1

UniprotKB/SwissProt: VGFR1_HUMAN (P17948)

Function: Receptor for VEGF, VEGFB and PGF. Has a tyrosine-protein kinase activity. The VEGF-kinase ligand/receptor signaling system plays a key role in vascular development and regulation of vascular permeability. Isoform SFlt1 may have an inhibitory role in angiogenesis.

Subcellular Localization: Isoform Flt1: Cell membrane; Single-pass type I membrane protein. Isoform sFlt1: Secreted.

Protein Domain:
PDB:1FLT

The substrate proteins of kinase FLT1

No.Gene NameUniProtKB IDProtein DescriptionNumber of kinase-specific phosphorylation sitesView
1FLT1VGFR1_HUMANVascular endothelial growth factor receptor 1 precursor (EC 2.7.10.1)(VEGFR-1) (Vascular permeability factor receptor) (Tyrosine-proteinkinase receptor FLT) (Flt-1) (Tyrosine-protein kinase FRT) (Fms-liketyrosine kinase 1). 8Show