Regulatory Network in Protein Phosphorylation
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Kinase: KDR kinase insert domain receptor (a type III receptor tyrosine kinase)

Group: TK      Family: VEGFR      

Description: kinase insert domain receptor (a type III receptor tyrosine kinase)

Gene Symbol: KDR

Synonyms: CD309, FLK1, VEGFR, VEGFR2

UniprotKB/SwissProt: VGFR2_HUMAN (P35968)

Function: Receptor for VEGF or VEGFC. Has a tyrosine-protein kinase activity. The VEGF-kinase ligand/receptor signaling system plays a key role in vascular development and regulation of vascular permeability. In case of HIV-1 infection, the interaction with extracellular viral Tat protein seems to enhance angiogenesis in Kaposi's sarcoma lesions.

Subcellular Localization: Membrane; Single-pass type I membrane protein.

Protein Domain:
PDB:1VR2

The substrate proteins of kinase KDR

No.Gene NameUniProtKB IDProtein DescriptionNumber of kinase-specific phosphorylation sitesView
1Q86W07_HUMANTyrosine-protein kinase receptor (EC 2.7.10.1). 3Show
2KDRVGFR2_HUMANVascular endothelial growth factor receptor 2 precursor (EC 2.7.10.1)(VEGFR-2) (Kinase insert domain receptor) (Protein-tyrosine kinasereceptor Flk-1) (CD309 antigen). 10Show