|Group: TK Family: VEGFR |
Description: kinase insert domain receptor (a type III receptor tyrosine kinase)
Gene Symbol: KDR
Synonyms: CD309, FLK1, VEGFR, VEGFR2
UniprotKB/SwissProt: VGFR2_HUMAN (P35968)
Function: Receptor for VEGF or VEGFC. Has a tyrosine-protein kinase activity. The VEGF-kinase ligand/receptor signaling system plays a key role in vascular development and regulation of vascular permeability. In case of HIV-1 infection, the interaction with extracellular viral Tat protein seems to enhance angiogenesis in Kaposi's sarcoma lesions.
Subcellular Localization: Membrane; Single-pass type I membrane protein.