|Group: TKL Family: IRAK |
Description: interleukin-1 receptor-associated kinase 4
Gene Symbol: IRAK4
Synonyms: NY-REN-64, REN64
UniprotKB/SwissProt: IRAK4_HUMAN (Q9NWZ3)
Function: Required for the efficient recruitment of IRAK1 to the IL-1 receptor complex following IL-1 engagement, triggering intracellular signaling cascades leading to transcriptional up- regulation and mRNA stabilization. Phosphorylates IRAK1.