Regulatory Network in Protein Phosphorylation
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Kinase: IRAK4 interleukin-1 receptor-associated kinase 4

Group: TKL      Family: IRAK      

Description: interleukin-1 receptor-associated kinase 4

Gene Symbol: IRAK4

Synonyms: NY-REN-64, REN64

UniprotKB/SwissProt: IRAK4_HUMAN (Q9NWZ3)

Function: Required for the efficient recruitment of IRAK1 to the IL-1 receptor complex following IL-1 engagement, triggering intracellular signaling cascades leading to transcriptional up- regulation and mRNA stabilization. Phosphorylates IRAK1.

Subcellular Localization:

Protein Domain:
PDB:2NRU

The substrate proteins of kinase IRAK4

No.Gene NameUniProtKB IDProtein DescriptionNumber of kinase-specific phosphorylation sitesView
1IRAK1IRAK1_HUMANInterleukin-1 receptor-associated kinase 1 (EC 2.7.11.1) (IRAK-1). 4Show



The substrate proteins of kinase family IRAK

 No.Gene NameUniProtKB IDProtein DescriptionNumber of kinase family-specific phosphorylated sitesView
1IRAK1IRAK1_HUMANInterleukin-1 receptor-associated kinase 1 (EC 2.7.11.1) (IRAK-1). 9Show
2STAT3STAT3_HUMANSignal transducer and activator of transcription 3 (Acute-phaseresponse factor). 1Show