Regulatory Network in Protein Phosphorylation
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Kinase: LIMK1 LIM domain kinase 1

Group: TKL      Family: LISK      Subfamily: LIMK

Description: LIM domain kinase 1

Gene Symbol: LIMK1

Synonyms: LIMK

UniprotKB/SwissProt: LIMK1_HUMAN (P53667)

Function: Protein kinase which regulates actin filament dynamics. Phosphorylates and inactivates the actin binding/depolymerizing factor cofilin, thereby stabilizing the actin cytoskeleton. Isoform 3 has a dominant negative effect on actin cytoskeletal changes. May be involved in brain development.

Subcellular Localization: Cytoplasm.

Protein Domain:

The substrate proteins of kinase LIMK1

No.Gene NameUniProtKB IDProtein DescriptionNumber of kinase-specific phosphorylation sitesView
1CFL1COF1_HUMANCofilin-1 (Cofilin, non-muscle isoform) (18 kDa phosphoprotein) (p18). 2Show
2CFL2COF2_HUMANCofilin-2 (Cofilin, muscle isoform). 3Show



The substrate proteins of kinase family LIMK

No.Gene NameUniProtKB IDProtein DescriptionNumber of kinase family-specific phosphorylated sitesView
1CFL1COF1_HUMANCofilin-1 (Cofilin, non-muscle isoform) (18 kDa phosphoprotein) (p18). 3Show
2CFL2COF2_HUMANCofilin-2 (Cofilin, muscle isoform). 3Show