Regulatory Network in Protein Phosphorylation
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Kinase: LIMK2 LIM domain kinase 2

Group: TKL      Family: LISK      Subfamily: LIMK

Description: LIM domain kinase 2

Gene Symbol: LIMK2

Synonyms: -

UniprotKB/SwissProt: LIMK2_HUMAN (P53671)

Function: Displays serine/threonine-specific phosphorylation of myelin basic protein and histone (MBP) in vitro.

Subcellular Localization: Cytoplasm. Nucleus. Note=Isoform LIMK2a is distributed in the cytoplasm and the nucleus, and isoform LIMK2b occurs mainly in the cytoplasm and is scarcely translocated to the nucleus.

Protein Domain:
PDB:1X6A

The substrate proteins of kinase LIMK2

No.Gene NameUniProtKB IDProtein DescriptionNumber of kinase-specific phosphorylation sitesView
1CFL1COF1_HUMANCofilin-1 (Cofilin, non-muscle isoform) (18 kDa phosphoprotein) (p18). 2Show



The substrate proteins of kinase family LIMK

No.Gene NameUniProtKB IDProtein DescriptionNumber of kinase family-specific phosphorylated sitesView
1CFL1COF1_HUMANCofilin-1 (Cofilin, non-muscle isoform) (18 kDa phosphoprotein) (p18). 3Show
2CFL2COF2_HUMANCofilin-2 (Cofilin, muscle isoform). 3Show