Regulatory Network in Protein Phosphorylation
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Kinase: ILK integrin-linked kinase

Group: TKL      Family: MLK      Subfamily: ILK

Description: integrin-linked kinase

Gene Symbol: ILK

Synonyms: DKFZp686F1765, P59

UniprotKB/SwissProt: ILK_HUMAN (Q13418)

Function: Receptor-proximal protein kinase regulating integrin- mediated signal transduction. May act as a mediator of inside-out integrin signaling. Focal adhesion protein part of the complex ILK-PINCH. This complex is considered to be one of the convergence points of integrin- and growth factor-signaling pathway. Could be implicated in mediating cell architecture, adhesion to integrin substrates and anchorage-dependent growth in epithelial cells. Phosphorylates beta-1 and beta-3 integrin subunit on serine and threonine residues, but also AKT1 and GSK3B.

Subcellular Localization: Cell junction, focal adhesion; Cytoplasmic side.

Protein Domain:

The substrate proteins of kinase ILK

No.Gene NameUniProtKB IDProtein DescriptionNumber of kinase-specific phosphorylation sitesView
1AKT1AKT1_HUMANRAC-alpha serine/threonine-protein kinase (EC 2.7.11.1) (RAC-PK-alpha)(Protein kinase B) (PKB) (C-AKT). 2Show
2ILKILK_HUMANIntegrin-linked protein kinase (EC 2.7.11.1) (ILK-1) (ILK-2) (59 kDaserine/threonine-protein kinase) (p59ILK). 2Show
3PPP1R12AMYPT1_HUMANProtein phosphatase 1 regulatory subunit 12A (Myosin phosphatase-targeting subunit 1) (Myosin phosphatase target subunit 1) (Proteinphosphatase myosin-binding subunit). 1Show
4NACANACA_HUMANNascent polypeptide-associated complex subunit alpha (NAC-alpha)(Alpha-NAC) (Hom s 2.02). 2Show
5PPP1R14APP14A_HUMANProtein phosphatase 1 regulatory subunit 14A (17 kDa PKC-potentiatedinhibitory protein of PP1) (CPI-17). 1Show
6PPP1R14BPP14B_HUMANProtein phosphatase 1 regulatory subunit 14B (Phospholipase C beta 3neighbouring gene protein). 1Show
7PPP1R14CPP14C_HUMANProtein phosphatase 1 regulatory subunit 14C (PKC-potentiated PP1inhibitory protein) (Kinase-enhanced PP1 inhibitor) (Serologicallydefined breast cancer antigen NY-BR-81). 1Show



The substrate proteins of kinase family ILK

No.Gene NameUniProtKB IDProtein DescriptionNumber of kinase family-specific phosphorylated sitesView
1AKT1AKT1_HUMANRAC-alpha serine/threonine-protein kinase (EC 2.7.11.1) (RAC-PK-alpha)(Protein kinase B) (PKB) (C-AKT). 2Show
2ILKILK_HUMANIntegrin-linked protein kinase (EC 2.7.11.1) (ILK-1) (ILK-2) (59 kDaserine/threonine-protein kinase) (p59ILK). 2Show
3PPP1R12AMYPT1_HUMANProtein phosphatase 1 regulatory subunit 12A (Myosin phosphatase-targeting subunit 1) (Myosin phosphatase target subunit 1) (Proteinphosphatase myosin-binding subunit). 1Show
4NACANACA_HUMANNascent polypeptide-associated complex subunit alpha (NAC-alpha)(Alpha-NAC) (Hom s 2.02). 2Show
5PPP1R14APP14A_HUMANProtein phosphatase 1 regulatory subunit 14A (17 kDa PKC-potentiatedinhibitory protein of PP1) (CPI-17). 1Show
6PPP1R14BPP14B_HUMANProtein phosphatase 1 regulatory subunit 14B (Phospholipase C beta 3neighbouring gene protein). 1Show
7PPP1R14CPP14C_HUMANProtein phosphatase 1 regulatory subunit 14C (PKC-potentiated PP1inhibitory protein) (Kinase-enhanced PP1 inhibitor) (Serologicallydefined breast cancer antigen NY-BR-81). 1Show