|Group: TKL Family: MLK Subfamily: LZK|
Description: mitogen-activated protein kinase kinase kinase 13
Gene Symbol: MAP3K13
Synonyms: LZK, MGC133196
UniprotKB/SwissProt: M3K13_HUMAN (O43283)
Function: Activates the JUN N-terminal pathway through activation of the MAP kinase kinase MAP2K7. Acts synergistically with PRDX3 to regulate the activation of NF-kappa-B in the cytosol. This activation is kinase-dependent and involves activating the IKK complex, the IKBKB-containing complex that phosphorylates inhibitors of NF-kappa-B.
Subcellular Localization: Cytoplasm. Membrane; Peripheral membrane protein.