Regulatory Network in Protein Phosphorylation
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Kinase: LZK mitogen-activated protein kinase kinase kinase 13

Group: TKL      Family: MLK      Subfamily: LZK

Description: mitogen-activated protein kinase kinase kinase 13

Gene Symbol: MAP3K13

Synonyms: LZK, MGC133196

UniprotKB/SwissProt: M3K13_HUMAN (O43283)

Function: Activates the JUN N-terminal pathway through activation of the MAP kinase kinase MAP2K7. Acts synergistically with PRDX3 to regulate the activation of NF-kappa-B in the cytosol. This activation is kinase-dependent and involves activating the IKK complex, the IKBKB-containing complex that phosphorylates inhibitors of NF-kappa-B.

Subcellular Localization: Cytoplasm. Membrane; Peripheral membrane protein.

Protein Domain: