Regulatory Network in Protein Phosphorylation
[Home] [About] [Browse Kinome] [Phosphorylation Prediction] [Expression Analysis] [Statistics] [Help] Version 1.0

[Back to Kinome Table]
Kinase: MLK3 mitogen-activated protein kinase kinase kinase 11

Group: TKL      Family: MLK      Subfamily: MLK

Description: mitogen-activated protein kinase kinase kinase 11

Gene Symbol: MAP3K11

Synonyms: MGC17114, MLK-3, MLK3, PTK1, SPRK

UniprotKB/SwissProt: M3K11_HUMAN (Q16584)

Function: Activates the JUN N-terminal pathway. Required for serum-stimulated cell proliferation and for mitogen and cytokine activation of MAPK14 (p38), MAPK3 (ERK) and MAPK8 (JNK1). Plays a role in mitogen-stimulated phosphorylation and activation of BRAF, but does not phosphorylate BRAF directly. Influences microtubule organization during the cell cycle.

Subcellular Localization: Centrosome. Note=Location is cell cycle dependent.

Protein Domain:

The substrate proteins of kinase MLK3

No.Gene NameUniProtKB IDProtein DescriptionNumber of kinase-specific phosphorylation sitesView
1MAP3K11M3K11_HUMANMitogen-activated protein kinase kinase kinase 11 (EC 2.7.11.25)(Mixed lineage kinase 3) (Src-homology 3 domain-containing proline-rich kinase). 3Show
2MAP2K4MP2K4_HUMANDual specificity mitogen-activated protein kinase kinase 4(EC 2.7.12.2) (MAP kinase kinase 4) (JNK-activating kinase 1) (c-JunN-terminal kinase kinase 1) (JNKK) (SAPK/ERK kinase 1) (SEK1). 1Show



The substrate proteins of kinase family MLK

No.Gene NameUniProtKB IDProtein DescriptionNumber of kinase family-specific phosphorylated sitesView
1CEACAM1CEAM1_HUMANCarcinoembryonic antigen-related cell adhesion molecule 1 precursor(Biliary glycoprotein 1) (BGP-1) (CD66 antigen) (CD66a antigen). 1Show
2MAP3K11M3K11_HUMANMitogen-activated protein kinase kinase kinase 11 (EC 2.7.11.25)(Mixed lineage kinase 3) (Src-homology 3 domain-containing proline-rich kinase). 3Show
3MAP3K9M3K9_HUMANMitogen-activated protein kinase kinase kinase 9 (EC 2.7.11.25) (Mixedlineage kinase 1). 1Show
4MAP2K4MP2K4_HUMANDual specificity mitogen-activated protein kinase kinase 4(EC 2.7.12.2) (MAP kinase kinase 4) (JNK-activating kinase 1) (c-JunN-terminal kinase kinase 1) (JNKK) (SAPK/ERK kinase 1) (SEK1). 1Show