Regulatory Network in Protein Phosphorylation
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Kinase: TAK1 mitogen-activated protein kinase kinase kinase 7

Group: TKL      Family: MLK      Subfamily: TAK1

Description: mitogen-activated protein kinase kinase kinase 7

Gene Symbol: MAP3K7

Synonyms: TAK1, TGF1a

UniprotKB/SwissProt: M3K7_HUMAN (O43318)

Function: Component of a protein kinase signal transduction cascade. Mediator of TGF-beta signal transduction. Stimulates NF- kappa-B activation and the p38 MAPK pathway.

Subcellular Localization:

Protein Domain:
PDB:2EVA

The substrate proteins of kinase TAK1

No.Gene NameUniProtKB IDProtein DescriptionNumber of kinase-specific phosphorylation sitesView
1IKBKBIKKB_HUMANInhibitor of nuclear factor kappa-B kinase subunit beta (EC 2.7.11.10)(I-kappa-B-kinase beta) (IkBKB) (IKK-beta) (IKK-B) (I-kappa-B kinase2) (IKK2) (Nuclear factor NF-kappa-B inhibitor kinase beta) (NFKBIKB). 2Show
2MAP3K7M3K7_HUMANMitogen-activated protein kinase kinase kinase 7 (EC 2.7.11.25)(Transforming growth factor-beta-activated kinase 1) (TGF-beta-activated kinase 1). 3Show
3SMAD3SMAD3_HUMANMothers against decapentaplegic homolog 3 (SMAD 3) (Mothers againstDPP homolog 3) (Mad3) (hMAD-3) (JV15-2) (hSMAD3). 3Show



The substrate proteins of kinase family TAK1

No.Gene NameUniProtKB IDProtein DescriptionNumber of kinase family-specific phosphorylated sitesView
1IKBKBIKKB_HUMANInhibitor of nuclear factor kappa-B kinase subunit beta (EC 2.7.11.10)(I-kappa-B-kinase beta) (IkBKB) (IKK-beta) (IKK-B) (I-kappa-B kinase2) (IKK2) (Nuclear factor NF-kappa-B inhibitor kinase beta) (NFKBIKB). 2Show
2MAP3K7M3K7_HUMANMitogen-activated protein kinase kinase kinase 7 (EC 2.7.11.25)(Transforming growth factor-beta-activated kinase 1) (TGF-beta-activated kinase 1). 3Show
3SMAD3SMAD3_HUMANMothers against decapentaplegic homolog 3 (SMAD 3) (Mothers againstDPP homolog 3) (Mad3) (hMAD-3) (JV15-2) (hSMAD3). 3Show