|Group: TKL Family: MLK Subfamily: ZAK|
Description: sterile alpha motif and leucine zipper containing kinase AZK
Gene Symbol: ZAK
Synonyms: AZK, MLK7, MLT, MLTK, MRK, mlklak
UniprotKB/SwissProt: MLTK_HUMAN (Q9NYL2)
Function: Stress-activated component of a protein kinase signal transduction cascade. Regulates the JNK and p38 pathways. Pro- apoptotic. Role in regulation of S and G2 cell cycle checkpoint by direct phosphorylation of CHEK2. Isoform 1, but not isoform 2, causes cell shrinkage and disruption of actin stress fibers. Isoform 1 may have role in neoplastic cell transformation and cancer development. Isoform 1, but not isoform 2, phosphorylates histone H3 at 'Ser-28'.
Subcellular Localization: Cytoplasm. Nucleus. Note=Translocates to the nucleus upon ultraviolet B irradiation.