|Group: TKL Family: RAF Subfamily: KSR|
Description: kinase suppressor of ras 1
Gene Symbol: KSR1
Synonyms: KSR, RSU2
UniprotKB/SwissProt: KSR1_HUMAN (Q8IVT5)
Function: Location-regulated scaffolding protein connecting MEK to RAF. Promotes MEK and RAF phosphorylation and activity through assembly of an activated signaling complex. By itself, it has no demonstrated kinase activity.
Subcellular Localization: Cytoplasm (By similarity). Membrane; Peripheral membrane protein (By similarity). Note=In unstimulated cells, where the phosphorylated form is bound to a 14-3-3 protein, sequestration in the cytoplasm occurs. Following growth factor treatment, the protei