|Group: TKL Family: RAF Subfamily: KSR|
Description: kinase suppressor of ras 2
Gene Symbol: KSR2
UniprotKB/SwissProt: KSR2_HUMAN (Q6VAB6)
Function: Location-regulated scaffold connecting MEK to RAF. Blocks MAP3K8 kinase activity and MAP3K8-mediated signaling. Acts as a negative regulator of MAP3K3-mediated activation of ERK, JNK and NF-kappa-B pathways, inhibiting MAP3K3-mediated interleukin-8 production.
Subcellular Localization: Cytoplasm (By similarity). Membrane; Peripheral membrane protein (By similarity).