Regulatory Network in Protein Phosphorylation
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Kinase: KSR1 kinase suppressor of ras 1

Group: TKL      Family: RAF      Subfamily: KSR

Description: kinase suppressor of ras 1

Gene Symbol: KSR1

Synonyms: KSR, RSU2

UniprotKB/SwissProt: KSR1_HUMAN (Q8IVT5)

Function: Location-regulated scaffolding protein connecting MEK to RAF. Promotes MEK and RAF phosphorylation and activity through assembly of an activated signaling complex. By itself, it has no demonstrated kinase activity.

Subcellular Localization: Cytoplasm (By similarity). Membrane; Peripheral membrane protein (By similarity). Note=In unstimulated cells, where the phosphorylated form is bound to a 14-3-3 protein, sequestration in the cytoplasm occurs. Following growth factor treatment, the protei

Protein Domain:

The substrate proteins of kinase KSR1

No.Gene NameUniProtKB IDProtein DescriptionNumber of kinase-specific phosphorylation sitesView
1RAF1RAF1_HUMANRAF proto-oncogene serine/threonine-protein kinase (EC 2.7.11.1) (Raf-1) (C-RAF) (cRaf). 1Show



The substrate proteins of kinase family KSR

No.Gene NameUniProtKB IDProtein DescriptionNumber of kinase family-specific phosphorylated sitesView
1RAF1RAF1_HUMANRAF proto-oncogene serine/threonine-protein kinase (EC 2.7.11.1) (Raf-1) (C-RAF) (cRaf). 1Show