Regulatory Network in Protein Phosphorylation
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Kinase: KSR2 kinase suppressor of ras 2

Group: TKL      Family: RAF      Subfamily: KSR

Description: kinase suppressor of ras 2

Gene Symbol: KSR2

Synonyms: FLJ25965

UniprotKB/SwissProt: KSR2_HUMAN (Q6VAB6)

Function: Location-regulated scaffold connecting MEK to RAF. Blocks MAP3K8 kinase activity and MAP3K8-mediated signaling. Acts as a negative regulator of MAP3K3-mediated activation of ERK, JNK and NF-kappa-B pathways, inhibiting MAP3K3-mediated interleukin-8 production.

Subcellular Localization: Cytoplasm (By similarity). Membrane; Peripheral membrane protein (By similarity).

Protein Domain:

The substrate proteins of kinase family KSR

No.Gene NameUniProtKB IDProtein DescriptionNumber of kinase family-specific phosphorylated sitesView
1RAF1RAF1_HUMANRAF proto-oncogene serine/threonine-protein kinase (EC 2.7.11.1) (Raf-1) (C-RAF) (cRaf). 1Show