Regulatory Network in Protein Phosphorylation
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Kinase: RAF1 v-raf-1 murine leukemia viral oncogene homolog 1

Group: TKL      Family: RAF      Subfamily: RAF

Description: v-raf-1 murine leukemia viral oncogene homolog 1

Gene Symbol: RAF1

Synonyms: CRAF, Raf-1, c-Raf

UniprotKB/SwissProt: RAF1_HUMAN (P04049)

Function: Involved in the transduction of mitogenic signals from the cell membrane to the nucleus. Part of the Ras-dependent signaling pathway from receptors to the nucleus. Protects cells from apoptosis mediated by STK3.

Subcellular Localization:

Protein Domain:
PDB:1C1Y

The substrate proteins of kinase RAF1

No.Gene NameUniProtKB IDProtein DescriptionNumber of kinase-specific phosphorylation sitesView
1MAPK1MK01_HUMANMitogen-activated protein kinase 1 (EC 2.7.11.24) (Extracellularsignal-regulated kinase 2) (ERK-2) (Mitogen-activated protein kinase2) (MAP kinase 2) (MAPK 2) (p42-MAPK) (ERT1). 1Show
2MAP2K1MP2K1_HUMANDual specificity mitogen-activated protein kinase kinase 1(EC 2.7.12.2) (MAP kinase kinase 1) (MAPKK 1) (ERK activator kinase 1)(MAPK/ERK kinase 1) (MEK1). 7Show
3RAF1RAF1_HUMANRAF proto-oncogene serine/threonine-protein kinase (EC 2.7.11.1) (Raf-1) (C-RAF) (cRaf). 2Show



The substrate proteins of kinase family RAF

No.Gene NameUniProtKB IDProtein DescriptionNumber of kinase family-specific phosphorylated sitesView
1MAPK1MK01_HUMANMitogen-activated protein kinase 1 (EC 2.7.11.24) (Extracellularsignal-regulated kinase 2) (ERK-2) (Mitogen-activated protein kinase2) (MAP kinase 2) (MAPK 2) (p42-MAPK) (ERT1). 1Show
2MAP2K1MP2K1_HUMANDual specificity mitogen-activated protein kinase kinase 1(EC 2.7.12.2) (MAP kinase kinase 1) (MAPKK 1) (ERK activator kinase 1)(MAPK/ERK kinase 1) (MEK1). 13Show
3MAP2K2MP2K2_HUMANDual specificity mitogen-activated protein kinase kinase 2(EC 2.7.12.2) (MAP kinase kinase 2) (MAPKK 2) (ERK activator kinase 2)(MAPK/ERK kinase 2) (MEK2). 1Show
4MYCMYC_HUMANMyc proto-oncogene protein (c-Myc) (Transcription factor p64). 1Show
5RAF1RAF1_HUMANRAF proto-oncogene serine/threonine-protein kinase (EC 2.7.11.1) (Raf-1) (C-RAF) (cRaf). 2Show