|Group: TKL Family: STKR Subfamily: Type1|
Description: transforming growth factor, beta receptor I (activin A receptor type II-like kinase, 53kDa)
Gene Symbol: TGFBR1
Synonyms: AAT5, ACVRLK4, ALK-5, ALK5, SKR4, TGFR-1
UniprotKB/SwissProt: TGFR1_HUMAN (P36897)
Function: On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for TGF-beta.
Subcellular Localization: Membrane; Single-pass type I membrane protein.