Regulatory Network in Protein Phosphorylation
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Kinase: TGFbR2 transforming growth factor, beta receptor II (70/80kDa)

Group: TKL      Family: STKR      Subfamily: Type2

Description: transforming growth factor, beta receptor II (70/80kDa)

Gene Symbol: TGFBR2

Synonyms: AAT3, FAA3, HNPCC6, MFS2, RIIC, TAAD2, TGFR-2, TGFbeta-RII

UniprotKB/SwissProt: TGFR2_HUMAN (P37173)

Function: On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for TGF-beta.

Subcellular Localization: Membrane; Single-pass type I membrane protein.

Protein Domain:
PDB:1KTZ

The substrate proteins of kinase TGFbR2

No.Gene NameUniProtKB IDProtein DescriptionNumber of kinase-specific phosphorylation sitesView
1TGFBR1TGFR1_HUMANTGF-beta receptor type-1 precursor (EC 2.7.11.30) (TGF-beta receptortype I) (TGFR-1) (TGF-beta type I receptor) (Transforming growthfactor-beta receptor type I) (TbetaR-I) (Serine/threonine-proteinkinase receptor R4) (SKR4) (Activin receptor-like kinase 5) (ALK-5). 2Show
2TGFBR2TGFR2_HUMANTGF-beta receptor type-2 precursor (EC 2.7.11.30) (TGF-beta receptortype II) (TGFR-2) (TGF-beta type II receptor) (Transforming growthfactor-beta receptor type II) (TbetaR-II). 10Show