Regulatory Network in Protein Phosphorylation
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Kinase: ALK1 activin A receptor type II-like 1

Group: TKL      Family: STKR      Subfamily: Type1

Description: activin A receptor type II-like 1

Gene Symbol: ACVRL1

Synonyms: ACVRLK1, ALK-1, ALK1, HHT, HHT2, ORW2, SKR3, TSR-I

UniprotKB/SwissProt: ACVL1_HUMAN (P37023)

Function: On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for TGF-beta. May bind activin as well.

Subcellular Localization: Membrane; Single-pass type I membrane protein.

Protein Domain: