|Group: TKL Family: STKR Subfamily: Type1|
Description: activin A receptor type II-like 1
Gene Symbol: ACVRL1
Synonyms: ACVRLK1, ALK-1, ALK1, HHT, HHT2, ORW2, SKR3, TSR-I
UniprotKB/SwissProt: ACVL1_HUMAN (P37023)
Function: On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for TGF-beta. May bind activin as well.
Subcellular Localization: Membrane; Single-pass type I membrane protein.