Regulatory Network in Protein Phosphorylation
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Kinase: ALK2 activin A receptor, type I

Group: TKL      Family: STKR      Subfamily: Type1

Description: activin A receptor, type I

Gene Symbol: ACVR1

Synonyms: ACTRI, ACVRLK2, ALK2, FOP, SKR1

UniprotKB/SwissProt: ACVR1_HUMAN (Q04771)

Function: On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for activin. May be involved for left-right pattern formation during embryogenesis (By similarity).

Subcellular Localization: Membrane; Single-pass type I membrane protein.

Protein Domain:

The substrate proteins of kinase ALK2

No.Gene NameUniProtKB IDProtein DescriptionNumber of kinase-specific phosphorylation sitesView
1SMAD1SMAD1_HUMANMothers against decapentaplegic homolog 1 (SMAD 1) (Mothers againstDPP homolog 1) (Mad-related protein 1) (Transforming growth factor-beta-signaling protein 1) (BSP-1) (hSMAD1) (JV4-1). 3Show