|Group: TKL Family: STKR Subfamily: Type1|
Description: activin A receptor, type I
Gene Symbol: ACVR1
Synonyms: ACTRI, ACVRLK2, ALK2, FOP, SKR1
UniprotKB/SwissProt: ACVR1_HUMAN (Q04771)
Function: On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for activin. May be involved for left-right pattern formation during embryogenesis (By similarity).
Subcellular Localization: Membrane; Single-pass type I membrane protein.