Regulatory Network in Protein Phosphorylation
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Kinase: ALK4 activin A receptor, type IB

Group: TKL      Family: STKR      Subfamily: Type1

Description: activin A receptor, type IB

Gene Symbol: ACVR1B

Synonyms: ACTRIB, ACVRLK4, ALK4, SKR2

UniprotKB/SwissProt: ACV1B_HUMAN (P36896)

Function: On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators.

Subcellular Localization: Membrane; Single-pass type I membrane protein.

Protein Domain:

The substrate proteins of kinase ALK4

No.Gene NameUniProtKB IDProtein DescriptionNumber of kinase-specific phosphorylation sitesView
1SMAD2SMAD2_HUMANMothers against decapentaplegic homolog 2 (SMAD 2) (Mothers againstDPP homolog 2) (Mad-related protein 2) (hMAD-2) (JV18-1) (hSMAD2). 3Show