|Group: TKL Family: STKR Subfamily: Type1|
Description: activin A receptor, type IB
Gene Symbol: ACVR1B
Synonyms: ACTRIB, ACVRLK4, ALK4, SKR2
UniprotKB/SwissProt: ACV1B_HUMAN (P36896)
Function: On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators.
Subcellular Localization: Membrane; Single-pass type I membrane protein.