Regulatory Network in Protein Phosphorylation
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Kinase: ALK7 activin A receptor, type IC

Group: TKL      Family: STKR      Subfamily: Type1

Description: activin A receptor, type IC

Gene Symbol: ACVR1C

Synonyms: ACVRLK7, ALK7

UniprotKB/SwissProt: ACV1C_HUMAN (Q8NER5)

Function: Serine/threonine protein kinase which forms a receptor complex on ligand binding. The receptor complex consisting of 2 type II and 2 type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators, SMAD2 and SMAD3. Receptor for activin AB, activin B and NODAL. Plays a role in cell differentiation, growth arrest and apoptosis.

Subcellular Localization: Membrane; Single-pass type I membrane protein.

Protein Domain: