|Group: TKL Family: STKR Subfamily: Type1|
Description: activin A receptor, type IC
Gene Symbol: ACVR1C
Synonyms: ACVRLK7, ALK7
UniprotKB/SwissProt: ACV1C_HUMAN (Q8NER5)
Function: Serine/threonine protein kinase which forms a receptor complex on ligand binding. The receptor complex consisting of 2 type II and 2 type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators, SMAD2 and SMAD3. Receptor for activin AB, activin B and NODAL. Plays a role in cell differentiation, growth arrest and apoptosis.
Subcellular Localization: Membrane; Single-pass type I membrane protein.