|Group: TKL Family: STKR Subfamily: Type1|
Description: bone morphogenetic protein receptor, type IA
Gene Symbol: BMPR1A
Synonyms: ACVRLK3, ALK3, CD292
UniprotKB/SwissProt: BMR1A_HUMAN (P36894)
Function: On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for BMP-2 and BMP-4.
Subcellular Localization: Membrane; Single-pass type I membrane protein.