Regulatory Network in Protein Phosphorylation
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Kinase: BMPR1B bone morphogenetic protein receptor, type IB

Group: TKL      Family: STKR      Subfamily: Type1

Description: bone morphogenetic protein receptor, type IB

Gene Symbol: BMPR1B

Synonyms: ALK-6, ALK6, CDw293

UniprotKB/SwissProt: BMR1B_HUMAN (O00238)

Function: On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for BMPS/OP-1.

Subcellular Localization: Membrane; Single-pass type I membrane protein.

Protein Domain:

The substrate proteins of kinase BMPR1B

No.Gene NameUniProtKB IDProtein DescriptionNumber of kinase-specific phosphorylation sitesView
1SMAD1SMAD1_HUMANMothers against decapentaplegic homolog 1 (SMAD 1) (Mothers againstDPP homolog 1) (Mad-related protein 1) (Transforming growth factor-beta-signaling protein 1) (BSP-1) (hSMAD1) (JV4-1). 3Show
2STAMBPSTABP_HUMANSTAM-binding protein (EC 3.1.2.15) (Associated molecule with the SH3domain of STAM). 5Show