|Group: TKL Family: STKR Subfamily: Type1|
Description: bone morphogenetic protein receptor, type IB
Gene Symbol: BMPR1B
Synonyms: ALK-6, ALK6, CDw293
UniprotKB/SwissProt: BMR1B_HUMAN (O00238)
Function: On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for BMPS/OP-1.
Subcellular Localization: Membrane; Single-pass type I membrane protein.