Regulatory Network in Protein Phosphorylation
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Kinase: TGFbR1 transforming growth factor, beta receptor I (activin A receptor type II-like kinase, 53kDa)

Group: TKL      Family: STKR      Subfamily: Type1

Description: transforming growth factor, beta receptor I (activin A receptor type II-like kinase, 53kDa)

Gene Symbol: TGFBR1

Synonyms: AAT5, ACVRLK4, ALK-5, ALK5, SKR4, TGFR-1

UniprotKB/SwissProt: TGFR1_HUMAN (P36897)

Function: On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for TGF-beta.

Subcellular Localization: Membrane; Single-pass type I membrane protein.

Protein Domain:
PDB:1B6C

The substrate proteins of kinase TGFbR1

No.Gene NameUniProtKB IDProtein DescriptionNumber of kinase-specific phosphorylation sitesView
1SMAD1SMAD1_HUMANMothers against decapentaplegic homolog 1 (SMAD 1) (Mothers againstDPP homolog 1) (Mad-related protein 1) (Transforming growth factor-beta-signaling protein 1) (BSP-1) (hSMAD1) (JV4-1). 6Show
2SMAD2SMAD2_HUMANMothers against decapentaplegic homolog 2 (SMAD 2) (Mothers againstDPP homolog 2) (Mad-related protein 2) (hMAD-2) (JV18-1) (hSMAD2). 7Show