Regulatory Network in Protein Phosphorylation
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Kinase: ACTR2B activin A receptor, type IIB

Group: TKL      Family: STKR      Subfamily: Type2

Description: activin A receptor, type IIB

Gene Symbol: ACVR2B

Synonyms: ActR-IIB, MGC116908

UniprotKB/SwissProt: AVR2B_HUMAN (Q13705)

Function: On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for activin A, activin B and inhibin A.

Subcellular Localization: Membrane; Single-pass type I membrane protein.

Protein Domain:
PDB:2H62