|Group: TKL Family: STKR Subfamily: Type2|
Description: activin A receptor, type IIB
Gene Symbol: ACVR2B
Synonyms: ActR-IIB, MGC116908
UniprotKB/SwissProt: AVR2B_HUMAN (Q13705)
Function: On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for activin A, activin B and inhibin A.
Subcellular Localization: Membrane; Single-pass type I membrane protein.