Regulatory Network in Protein Phosphorylation
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Kinase: BMPR2 bone morphogenetic protein receptor, type II (serine/threonine kinase)

Group: TKL      Family: STKR      Subfamily: Type2

Description: bone morphogenetic protein receptor, type II (serine/threonine kinase)

Gene Symbol: BMPR2

Synonyms: BMPR-II, BMPR3, BMR2, BRK-3, T-ALK

UniprotKB/SwissProt: BMPR2_HUMAN (Q13873)

Function: On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Binds to BMP-7, BMP-2 and, less efficiently, BMP-4. Binding is weak but enhanced by the presence of type I receptors for BMPs.

Subcellular Localization: Membrane; Single-pass type I membrane protein.

Protein Domain: