|Group: TKL Family: STKR Subfamily: Type2|
Description: bone morphogenetic protein receptor, type II (serine/threonine kinase)
Gene Symbol: BMPR2
Synonyms: BMPR-II, BMPR3, BMR2, BRK-3, T-ALK
UniprotKB/SwissProt: BMPR2_HUMAN (Q13873)
Function: On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Binds to BMP-7, BMP-2 and, less efficiently, BMP-4. Binding is weak but enhanced by the presence of type I receptors for BMPs.
Subcellular Localization: Membrane; Single-pass type I membrane protein.