Regulatory Network in Protein Phosphorylation
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Kinase: CDK8 cyclin-dependent kinase 8

Group: CMGC      Family: CDK      Subfamily: CDK8

Description: cyclin-dependent kinase 8

Gene Symbol: CDK8

Synonyms: K35, MGC126074, MGC126075

UniprotKB/SwissProt: CDK8_HUMAN (P49336)

Function: Component of the Mediator complex, a coactivator involved in regulated gene transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. Phosphorylates the CTD (C-terminal domain) of the large subunit of RNA polymerase II (RNAp II), which may inhibit the formation of a transcription initiation complex. Phosphorylates CCNH leading to down-regulation of the TFIIH complex and transcriptional repression. Recruited through interaction with MAML1 to hyperphosphorylate the intracellular domain of NOTCH, leading to its degradation.

Subcellular Localization: Nucleus (Probable).

Protein Domain:

The substrate proteins of kinase CDK8

No.Gene NameUniProtKB IDProtein DescriptionNumber of kinase-specific phosphorylation sitesView
1CCNHCCNH_HUMANCyclin-H (MO15-associated protein) (p37) (p34). 4Show

The substrate proteins of kinase family CDK8

No.Gene NameUniProtKB IDProtein DescriptionNumber of kinase family-specific phosphorylated sitesView
1CCNHCCNH_HUMANCyclin-H (MO15-associated protein) (p37) (p34). 4Show