Regulatory Network in Protein Phosphorylation
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The substrate proteins of kinase CK2_group

No.Gene NameUniProtKB IDProtein DescriptionNumber of kinase-specific phosphorylation sitesView
1APPA4_HUMANAmyloid beta A4 protein precursor (APP) (ABPP) (Alzheimer diseaseamyloid protein) (Cerebral vascular amyloid peptide) (CVAP) (Proteasenexin-II) (PN-II) (APPI) (PreA4) [Contains: Soluble APP-alpha (S-APP-alpha); Soluble APP-beta (S-APP-beta); C99; Beta-amyloid protein 42(Beta-APP42); Beta-amyloid protein 40 (Beta-APP40); C83; P3(42);P3(40); Gamma-CTF(59) (Gamma-secretase C-terminal fragment 59)(Amyloid intracellular domain 59) (AID(59)) (AICD-59); Gamma-CTF(57)(Gamma-secretase C-terminal fragment 57) (Amyloid intracellular domain57) (AID(57)) (AICD-57); Gamma-CTF(50) (Gamma-secretase C-terminalfragment 50) (Amyloid intracellular domain 50) (AID(50)) (AICD-50);C31]. 1Show
2ACACAACACA_HUMANAcetyl-CoA carboxylase 1 (EC 6.4.1.2) (ACC-alpha) [Includes: Biotincarboxylase (EC 6.3.4.14)]. 1Show
3ANP32AAN32A_HUMANAcidic leucine-rich nuclear phosphoprotein 32 family member A (Potentheat-stable protein phosphatase 2A inhibitor I1PP2A) (Acidic nuclearphosphoprotein pp32) (Leucine-rich acidic nuclear protein) (Lanp)(Putative HLA-DR-associated protein I) (PHAPI) (Mapmodulin). 2Show
4APEX1APEX1_HUMANDNA-(apurinic or apyrimidinic site) lyase (EC 4.2.99.18) (APendonuclease 1) (APEX nuclease) (APEN) (Protein REF-1). 1Show
5AQP4AQP4_HUMANAquaporin-4 (AQP-4) (WCH4) (Mercurial-insensitive water channel)(MIWC). 3Show
6ARRB2ARRB2_HUMANBeta-arrestin-2 (Arrestin beta 2). 1Show
7ATF1ATF1_HUMANCyclic AMP-dependent transcription factor ATF-1 (Activatingtranscription factor 1) (TREB36 protein). 1Show
8BIDBID_HUMANBH3-interacting domain death agonist (BID) (p22 BID) [Contains: BH3-interacting domain death agonist p15 (p15 BID); BH3-interacting domaindeath agonist p13 (p13 BID); BH3-interacting domain death agonist p11(p11 BID)]. 2Show
9C1RC1R_HUMANComplement C1r subcomponent precursor (EC 3.4.21.41) (Complementcomponent 1, r subcomponent) [Contains: Complement C1r subcomponentheavy chain; Complement C1r subcomponent light chain]. 2Show
10CDH1CADH1_HUMANEpithelial cadherin precursor (E-cadherin) (Uvomorulin) (Cadherin-1)(CAM 120/80) (CD324 antigen) [Contains: E-Cad/CTF1; E-Cad/CTF2; E-Cad/CTF3]. 1Show
11CALM1CALM_HUMANCalmodulin (CaM). 2Show
12CANXCALX_HUMANCalnexin precursor (Major histocompatibility complex class I antigen-binding protein p88) (p90) (IP90). 2Show
13CAV1CAV1_HUMANCaveolin-1. 1Show
14CCNHCCNH_HUMANCyclin-H (MO15-associated protein) (p37) (p34). 1Show
15MS4A1CD20_HUMANB-lymphocyte antigen CD20 (Membrane-spanning 4-domains subfamily Amember 1) (B-lymphocyte surface antigen B1) (Leu-16) (Bp35). 3Show
16PTPRCCD45_HUMANLeukocyte common antigen precursor (EC 3.1.3.48) (L-CA) (T200) (CD45antigen). 3Show
17CD5CD5_HUMANT-cell surface glycoprotein CD5 precursor (Lymphocyte antigen T1/Leu-1) (CD5 antigen). 3Show
18CDC2CDC2_HUMANCell division control protein 2 homolog (EC 2.7.11.22) (EC 2.7.11.23)(p34 protein kinase) (Cyclin-dependent kinase 1) (CDK1). 1Show
19CDC37CDC37_HUMANHsp90 co-chaperone Cdc37 (Hsp90 chaperone protein kinase-targetingsubunit) (p50Cdc37). 1Show
20COL17A1COHA1_HUMANCollagen alpha-1(XVII) chain (Bullous pemphigoid antigen 2) (180 kDabullous pemphigoid antigen 2). 1Show
21CSNK2BCSK2B_HUMANCasein kinase II subunit beta (CK II beta) (Phosvitin) (G5a). 2Show
22CTDP1CTDP1_HUMANRNA polymerase II subunit A C-terminal domain phosphatase(EC 3.1.3.16) (TFIIF-associating CTD phosphatase). 2Show
23CTNNB1CTNB1_HUMANCatenin beta-1 (Beta-catenin). 3Show
24ODC1DCOR_HUMANOrnithine decarboxylase (EC 4.1.1.17) (ODC). 1Show
25DCXDCX_HUMANNeuronal migration protein doublecortin (Lissencephalin-X) (Lis-X)(Doublin). 6Show
26DDIT3DDIT3_HUMANDNA damage-inducible transcript 3 (DDIT-3) (Growth arrest and DNA-damage-inducible protein GADD153) (C/EBP-homologous protein) (CHOP). 4Show
27LIG1DNL1_HUMANDNA ligase 1 (EC 6.5.1.1) (DNA ligase I) (Polydeoxyribonucleotidesynthase [ATP] 1). 1Show
28EGR1EGR1_HUMANEarly growth response protein 1 (EGR-1) (Protein Krox-24)(Transcription factor Zif268) (Nerve growth factor-induced protein A)(NGFI-A) (Transcription factor ETR103) (Zinc finger protein 225)(AT225). 1Show
29ESR1ESR1_HUMANEstrogen receptor (ER) (Estradiol receptor) (ER-alpha) (Nuclearreceptor subfamily 3 group A member 1). 2Show
30F5FA5_HUMANCoagulation factor V precursor (Activated protein C cofactor)[Contains: Coagulation factor V heavy chain; Coagulation factor Vlight chain]. 1Show
31FAF1FAF1_HUMANFAS-associated factor 1 (Protein FAF1) (hFAF1). 2Show
32FKBP4FKBP4_HUMANFK506-binding protein 4 (EC 5.2.1.8) (Peptidyl-prolyl cis-transisomerase) (PPIase) (Rotamase) (p59 protein) (HSP-bindingimmunophilin) (HBI) (FKBP52 protein) (52 kDa FK506-binding protein)(FKBP59). 1Show
33FURINFURIN_HUMANFurin precursor (EC 3.4.21.75) (Paired basic amino acid residuecleaving enzyme) (PACE) (Dibasic-processing enzyme). 2Show
34GPIG6PI_HUMANGlucose-6-phosphate isomerase (EC 5.3.1.9) (GPI) (Phosphoglucoseisomerase) (PGI) (Phosphohexose isomerase) (PHI) (Neuroleukin) (NLK)(Sperm antigen 36) (SA-36). 1Show
35GGA1GGA1_HUMANADP-ribosylation factor-binding protein GGA1 (Golgi-localized, gammaear-containing, ARF-binding protein 1) (Gamma-adaptin-related protein1). 1Show
36HDAC1HDAC1_HUMANHistone deacetylase 1 (HD1). 4Show
37HDAC2HDAC2_HUMANHistone deacetylase 2 (HD2). 3Show
38HMGA1HMGA1_HUMANHigh mobility group protein HMG-I/HMG-Y (HMG-I(Y)) (High mobilitygroup AT-hook protein 1) (High mobility group protein A1) (Highmobility group protein-R). 3Show
39HNRNPCHNRPC_HUMANHeterogeneous nuclear ribonucleoproteins C1/C2 (hnRNP C1 / hnRNP C2). 1Show
40HSP90AA1HS90A_HUMANHeat shock protein HSP 90-alpha (HSP 86) (Renal carcinoma antigen NY-REN-38). 2Show
41HSP90AB1HS90B_HUMANHeat shock protein HSP 90-beta (HSP 84) (HSP 90). 2Show
42HSF1HSF1_HUMANHeat shock factor protein 1 (HSF 1) (Heat shock transcription factor1) (HSTF 1). 1Show
43HOXB7HXB7_HUMANHomeobox protein Hox-B7 (Hox-2C) (HHO.C1). 2Show
44IGFBP3IBP3_HUMANInsulin-like growth factor-binding protein 3 precursor (IGFBP-3) (IBP-3) (IGF-binding protein 3). 2Show
45IFI16IF16_HUMANGamma-interferon-inducible protein Ifi-16 (Interferon-induciblemyeloid differentiation transcriptional activator) (IFI 16). 1Show
46NFKBIAIKBA_HUMANNF-kappa-B inhibitor alpha (Major histocompatibility complex enhancer-binding protein MAD3) (I-kappa-B-alpha) (IkappaBalpha) (IkB-alpha). 4Show
47PPP1R2P1IPP2L_HUMANProtein phosphatase inhibitor 2-like protein 1 (Protein phosphatase 1,regulatory subunit 2 pseudogene 1). 1Show
48PPP1R2IPP2_HUMANProtein phosphatase inhibitor 2 (IPP-2). 4Show
49IRS1IRS1_HUMANInsulin receptor substrate 1 (IRS-1). 2Show
50JUNJUN_HUMANTranscription factor AP-1 (Activator protein 1) (AP1) (Proto-oncogenec-jun) (V-jun avian sarcoma virus 17 oncogene homolog) (p39). 4Show
51KIF1CKIF1C_HUMANKinesin-like protein KIF1C. 1Show
52KLF1KLF1_HUMANKrueppel-like factor 1 (Erythroid krueppel-like transcription factor)(EKLF) (Erythroid transcription factor). 1Show
53L1CAML1CAM_HUMANNeural cell adhesion molecule L1 precursor (N-CAM L1) (CD171 antigen). 1Show
54SSBLA_HUMANLupus La protein (Sjoegren syndrome type B antigen) (SS-B) (Laribonucleoprotein) (La autoantigen). 2Show
55MAXMAX_HUMANProtein max (Myc-associated factor X). 2Show
56MAZMAZ_HUMANMyc-associated zinc finger protein (MAZI) (Purine-bindingtranscription factor) (Pur-1) (ZF87) (ZIF87). 1Show
57MEF2CMEF2C_HUMANMyocyte-specific enhancer factor 2C. 2Show
58CDC25BMPIP2_HUMANM-phase inducer phosphatase 2 (EC 3.1.3.48) (Dual specificityphosphatase Cdc25B). 2Show
59MYBMYB_HUMANMyb proto-oncogene protein (C-myb). 2Show
60MYCNMYCN_HUMANN-myc proto-oncogene protein. 4Show
61MYF5MYF5_HUMANMyogenic factor 5 (Myf-5). 2Show
62NCF1NCF1_HUMANNeutrophil cytosol factor 1 (NCF-1) (Neutrophil NADPH oxidase factor1) (47 kDa neutrophil oxidase factor) (p47-phox) (NCF-47K) (47 kDaautosomal chronic granulomatous disease protein) (Nox organizer 2)(Nox-organizing protein 2) (SH3 and PX domain-containing protein 1A). 3Show
63GAP43NEUM_HUMANNeuromodulin (Axonal membrane protein GAP-43) (Growth-associatedprotein 43) (PP46) (Neural phosphoprotein B-50). 2Show
64NRF1NRF1_HUMANNuclear respiratory factor 1 (NRF-1) (Alpha palindromic-bindingprotein) (Alpha-pal). 5Show
65OCLNOCLN_HUMANOccludin. 2Show
66TP53P53_HUMANCellular tumor antigen p53 (Tumor suppressor p53) (Phosphoprotein p53)(Antigen NY-CO-13). 2Show
67PACS1PACS1_HUMANPhosphofurin acidic cluster sorting protein 1 (PACS-1). 1Show
68SERPINF1PEDF_HUMANPigment epithelium-derived factor precursor (PEDF) (Serpin-F1) (EPC-1). 2Show
69PIN4PIN4_HUMANPeptidyl-prolyl cis-trans isomerase NIMA-interacting 4 (EC 5.2.1.8)(Rotamase Pin4) (PPIase Pin4) (Parvulin 14) (Par14) (Peptidyl-prolylcis/trans isomerase EPVH) (hPar14). 1Show
70PPP1R8PP1R8_HUMANNuclear inhibitor of protein phosphatase 1 (NIPP-1) (Proteinphosphatase 1 regulatory inhibitor subunit 8) [Includes: Activator ofRNA decay (EC 3.1.4.-) (ARD-1)]. 2Show
71PGRPRGR_HUMANProgesterone receptor (PR) (Nuclear receptor subfamily 3 group Cmember 3). 1Show
72PSMA3PSA3_HUMANProteasome subunit alpha type-3 (EC 3.4.25.1) (Proteasome componentC8) (Macropain subunit C8) (Multicatalytic endopeptidase complexsubunit C8). 2Show
73PSEN2PSN2_HUMANPresenilin-2 (EC 3.4.23.-) (PS-2) (STM-2) (E5-1) (AD3LP) (AD5)[Contains: Presenilin-2 NTF subunit; Presenilin-2 CTF subunit]. 4Show
74PTENPTEN_HUMANPhosphatidylinositol-3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN (EC 3.1.3.67) (EC 3.1.3.16)(EC 3.1.3.48) (Phosphatase and tensin homolog) (Mutated in multipleadvanced cancers 1). 5Show
75PTMAPTMA_HUMANProthymosin alpha [Contains: Thymosin alpha-1]. 3Show
76Q6VVE6_HUMANNeural interleukin 16 protein. 1Show
77RRADRAD_HUMANGTP-binding protein RAD (RAS associated with diabetes) (RAD1). 1Show
78RBBP9RBBP9_HUMANRetinoblastoma-binding protein 9 (RBBP-9) (Retinoblastoma-bindingprotein 10) (RBBP-10) (B5T overexpressed gene protein) (Bog protein). 2Show
79RNF7RBX2_HUMANRING-box protein 2 (Rbx2) (RING finger protein 7) (Regulator ofcullins 2) (CKII beta-binding protein 1) (CKBBP1) (Sensitive toapoptosis gene protein). 2Show
80RGS19RGS19_HUMANRegulator of G-protein signaling 19 (RGS19) (G-alpha-interactingprotein) (GAIP). 2Show
81RGS1RGS1_HUMANRegulator of G-protein signaling 1 (RGS1) (Early response protein1R20) (B-cell activation protein BL34). 4Show
82RNPS1RNPS1_HUMANRNA-binding protein with serine-rich domain 1 (SR-related proteinLDC2). 1Show
83POLR2FRPAB2_HUMANDNA-directed RNA polymerases I, II, and III subunit RPABC2 (RNApolymerases I, II, and III subunit ABC2) (DNA-directed RNA polymeraseII subunit F) (RPB6) (DNA-directed RNA polymerases I, II, and III 14.4kDa polypeptide) (RPABC14.4) (RPB14.4) (RPC15). 2Show
84SAT1SAT1_HUMANDiamine acetyltransferase 1 (EC 2.3.1.57) (Spermidine/spermine N(1)-acetyltransferase 1) (SSAT) (SSAT-1) (Putrescine acetyltransferase)(Polyamine N-acetyltransferase 1). 3Show
85SP1SP1_HUMANTranscription factor Sp1. 1Show
86SPIBSPIB_HUMANTranscription factor Spi-B. 4Show
87SRPK1SRPK1_HUMANSerine/threonine-protein kinase SRPK1 (EC 2.7.11.1) (Serine/arginine-rich protein-specific kinase 1) (SR-protein-specific kinase 1) (SFRSprotein kinase 1). 2Show
88SRPK2SRPK2_HUMANSerine/threonine-protein kinase SRPK2 (EC 2.7.11.1) (Serine/arginine-rich protein-specific kinase 2) (SR-protein-specific kinase 2) (SFRSprotein kinase 2). 2Show
89SSRP1SSRP1_HUMANFACT complex subunit SSRP1 (Facilitates chromatin transcriptioncomplex subunit SSRP1) (FACT 80 kDa subunit) (FACTp80) (Chromatin-specific transcription elongation factor 80 kDa subunit) (Structure-specific recognition protein 1) (hSSRP1) (Recombination signalsequence recognition protein 1) (T160). 2Show
90STX1ASTX1A_HUMANSyntaxin-1A (Neuron-specific antigen HPC-1). 1Show
91SNCASYUA_HUMANAlpha-synuclein (Non-A beta component of AD amyloid) (Non-A4 componentof amyloid precursor) (NACP). 2Show
92SNCBSYUB_HUMANBeta-synuclein. 1Show
93SNCGSYUG_HUMANGamma-synuclein (Persyn) (Breast cancer-specific gene 1 protein)(Synoretin) (SR). 1Show
94SUB1TCP4_HUMANActivated RNA polymerase II transcriptional coactivator p15 (SUB1homolog) (Positive cofactor 4) (PC4) (p14). 5Show
95GTF2A1TF2AA_HUMANTranscription initiation factor IIA subunit 1 (General transcriptionfactor IIA1) (TFIIA-42) (TFIIAL) [Contains: Transcription initiationfactor IIA alpha chain (TFIIA p35 subunit); Transcription initiationfactor IIA beta chain (TFIIA p19 subunit)]. 4Show
96GTF2A1LTF2AY_HUMANTFIIA-alpha and beta-like factor (General transcription factor II A,1-like factor). 4Show
97RELATF65_HUMANTranscription factor p65 (Nuclear factor NF-kappa-B p65 subunit). 1Show
98TCF7L2TF7L2_HUMANTranscription factor 7-like 2 (HMG box transcription factor 4) (T-cell-specific transcription factor 4) (TCF-4) (hTCF-4). 3Show
99TLE1TLE1_HUMANTransducin-like enhancer protein 1 (ESG1) (E(Sp1) homolog). 1Show
100TLE2TLE2_HUMANTransducin-like enhancer protein 2 (ESG2). 1Show
101TLE4TLE4_HUMANTransducin-like enhancer protein 4. 1Show
102TNFTNFA_HUMANTumor necrosis factor precursor (TNF-alpha) (Tumor necrosis factorligand superfamily member 2) (TNF-a) (Cachectin) [Contains: Tumornecrosis factor, membrane form; Tumor necrosis factor, soluble form]. 1Show
103TNNT1TNNT1_HUMANTroponin T, slow skeletal muscle (TnTs) (Slow skeletal muscle troponinT) (sTnT). 1Show
104TNNT2TNNT2_HUMANTroponin T, cardiac muscle (TnTc) (Cardiac muscle troponin T) (cTnT). 1Show
105TNNT3TNNT3_HUMANTroponin T, fast skeletal muscle (TnTf) (Fast skeletal muscle troponinT) (fTnT) (Beta TnTF). 1Show
106TOP2ATOP2A_HUMANDNA topoisomerase 2-alpha (EC 5.99.1.3) (DNA topoisomerase II, alphaisozyme). 4Show
107CDC34UB2R1_HUMANUbiquitin-conjugating enzyme E2 R1 (EC 6.3.2.19) (Ubiquitin-proteinligase R1) (Ubiquitin-conjugating enzyme E2-32 kDa complementing) (E2-CDC34). 6Show
108UBE2R2UB2R2_HUMANUbiquitin-conjugating enzyme E2 R2 (EC 6.3.2.19) (Ubiquitin-proteinligase R2) (Ubiquitin carrier protein R2) (E2-CDC34B). 1Show
109UBA1UBA1_HUMANUbiquitin-like modifier-activating enzyme 1 (Ubiquitin-activatingenzyme E1) (Protein A1S9). 1Show
110VAMP4VAMP4_HUMANVesicle-associated membrane protein 4 (VAMP-4). 1Show
111VDRVDR_HUMANVitamin D3 receptor (VDR) (1,25-dihydroxyvitamin D3 receptor) (Nuclearreceptor subfamily 1 group I member 1). 1Show
112SLC18A2VMAT2_HUMANSynaptic vesicular amine transporter (Monoamine transporter)(Vesicular amine transporter 2) (VAT2) (Solute carrier family 18member 2). 4Show
113VPS72VPS72_HUMANVacuolar protein sorting-associated protein 72 homolog (Transcriptionfactor-like 1) (Protein YL-1). 4Show
114VTNVTNC_HUMANVitronectin precursor (Serum-spreading factor) (S-protein) (V75)[Contains: Vitronectin V65 subunit; Vitronectin V10 subunit;Somatomedin-B]. 4Show
115WASWASP_HUMANWiskott-Aldrich syndrome protein (WASp). 2Show
116XKXK_HUMANMembrane transport protein XK (Kx antigen) (Kell complex 37 kDacomponent) (XK-related protein 1). 1Show