Regulatory Network in Protein Phosphorylation
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Kinase: GPRK4(GRK4) G protein-coupled receptor kinase 4

Group: AGC      Family: GRK      Subfamily: GRK

Description: G protein-coupled receptor kinase 4

Gene Symbol: GRK4

Synonyms: GPRK2L, GPRK4, GRK4a, IT11

UniprotKB/SwissProt: GRK4_HUMAN (P32298)

Function: Specifically phosphorylates the activated forms of G protein-coupled receptors. GRK4-alpha can phosphorylate rhodopsin and its activity is inhibited by calmodulin; the other three isoforms do not phosphorylate rhodopsin and do not interact with calmodulin.

Subcellular Localization:

Protein Domain:

The substrate proteins of kinase GPRK4(GRK4)

No.Gene NameUniProtKB IDProtein DescriptionNumber of kinase-specific phosphorylation sitesView
1BDKRB2BKRB2_HUMANB2 bradykinin receptor (BK-2 receptor) (B2R). 6Show

The substrate proteins of kinase family GRK

No.Gene NameUniProtKB IDProtein DescriptionNumber of kinase family-specific phosphorylated sitesView
1CHRM2ACM2_HUMANMuscarinic acetylcholine receptor M2. 17Show
2ADRB2ADRB2_HUMANBeta-2 adrenergic receptor (Beta-2 adrenoceptor) (Beta-2adrenoreceptor). 8Show
3BDKRB2BKRB2_HUMANB2 bradykinin receptor (BK-2 receptor) (B2R). 3Show
4CCR5CCR5_HUMANC-C chemokine receptor type 5 (C-C CKR-5) (CC-CKR-5) (CCR-5) (CCR5)(HIV-1 fusion coreceptor) (CHEMR13) (CD195 antigen). 4Show
5PDE6GCNRG_HUMANRetinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterasesubunit gamma (EC (GMP-PDE gamma). 1Show
6VIL2EZRI_HUMANEzrin (p81) (Cytovillin) (Villin-2). 1Show
7FPR1FPR1_HUMANfMet-Leu-Phe receptor (fMLP receptor) (N-formyl peptide receptor)(FPR) (N-formylpeptide chemoattractant receptor). 8Show
8GRK5GRK5_HUMANG protein-coupled receptor kinase 5 (EC (G protein-coupledreceptor kinase GRK5). 2Show
9HRH1HRH1_HUMANHistamine H1 receptor. 1Show
10LTB4RLT4R1_HUMANLeukotriene B4 receptor 1 (LTB4-R 1) (P2Y purinoceptor 7) (P2Y7)(Chemoattractant receptor-like 1) (G-protein coupled receptor 16). 1Show
11MC4RMC4R_HUMANMelanocortin receptor 4 (MC4-R). 3Show
12SLC9A3R1NHERF_HUMANEzrin-radixin-moesin-binding phosphoprotein 50 (EBP50) (Na(+)/H(+)exchange regulatory cofactor NHE-RF) (NHERF-1) (Regulatory cofactor ofNa(+)/H(+) exchanger) (Sodium-hydrogen exchanger regulatory factor 1)(Solute carrier family 9 isoform A3 regulatory factor 1). 1Show
13OPRD1OPRD_HUMANDelta-type opioid receptor (DOR-1). 3Show
14RHOOPSD_HUMANRhodopsin (Opsin-2). 3Show
15PDGFRBPGFRB_HUMANBeta-type platelet-derived growth factor receptor precursor(EC (PDGF-R-beta) (CD140b antigen). 1Show
16RPLP2RLA2_HUMAN60S acidic ribosomal protein P2 (Renal carcinoma antigen NY-REN-44). 2Show
17SNCASYUA_HUMANAlpha-synuclein (Non-A beta component of AD amyloid) (Non-A4 componentof amyloid precursor) (NACP). 2Show
18SNCBSYUB_HUMANBeta-synuclein. 1Show
19TUBB3TBB3_HUMANTubulin beta-3 chain (Tubulin beta-III) (Tubulin beta-4). 3Show