|Group: TKL Family: MLK Subfamily: MLK|
Description: mitogen-activated protein kinase kinase kinase 11
Gene Symbol: MAP3K11
Synonyms: MGC17114, MLK-3, MLK3, PTK1, SPRK
UniprotKB/SwissProt: M3K11_HUMAN (Q16584)
Function: Activates the JUN N-terminal pathway. Required for serum-stimulated cell proliferation and for mitogen and cytokine activation of MAPK14 (p38), MAPK3 (ERK) and MAPK8 (JNK1). Plays a role in mitogen-stimulated phosphorylation and activation of BRAF, but does not phosphorylate BRAF directly. Influences microtubule organization during the cell cycle.
Subcellular Localization: Centrosome. Note=Location is cell cycle dependent.