Regulatory Network in Protein Phosphorylation
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The substrate proteins of kinase PKC_group

No.Gene NameUniProtKB IDProtein DescriptionNumber of kinase-specific phosphorylation sitesView
1HLA-A1A01_HUMANHLA class I histocompatibility antigen, A-1 alpha chain precursor (MHCclass I antigen A*1). 1Show
2ADRA2AADA2A_HUMANAlpha-2A adrenergic receptor (Alpha-2A adrenoceptor) (Alpha-2Aadrenoreceptor) (Alpha-2AAR) (Alpha-2 adrenergic receptor subtypeC10). 1Show
3ADD1ADDA_HUMANAlpha-adducin (Erythrocyte adducin subunit alpha). 3Show
4ADD2ADDB_HUMANBeta-adducin (Erythrocyte adducin subunit beta). 4Show
5ADD3ADDG_HUMANGamma-adducin (Adducin-like protein 70). 2Show
6PAMAMD_HUMANPeptidyl-glycine alpha-amidating monooxygenase precursor (PAM)[Includes: Peptidylglycine alpha-hydroxylating monooxygenase(EC 1.14.17.3) (PHM); Peptidyl-alpha-hydroxyglycine alpha-amidatinglyase (EC 4.3.2.5) (Peptidylamidoglycolate lyase) (PAL)]. 2Show
7ANXA1ANXA1_HUMANAnnexin A1 (Annexin-1) (Annexin I) (Lipocortin I) (Calpactin II)(Chromobindin-9) (p35) (Phospholipase A2 inhibitory protein). 4Show
8ANXA2ANXA2_HUMANAnnexin A2 (Annexin-2) (Annexin II) (Lipocortin II) (Calpactin I heavychain) (Chromobindin-8) (p36) (Protein I) (Placental anticoagulantprotein IV) (PAP-IV). 2Show
9APLP2APLP2_HUMANAmyloid-like protein 2 precursor (Amyloid protein homolog) (APPH)(CDEI box-binding protein) (CDEBP). 1Show
10ASGR2ASGR2_HUMANAsialoglycoprotein receptor 2 (ASGP-R 2) (ASGPR 2) (Hepatic lectinH2). 1Show
11ATP1A1AT1A1_HUMANSodium/potassium-transporting ATPase subunit alpha-1 precursor(EC 3.6.3.9) (Sodium pump subunit alpha-1) (Na(+)/K(+) ATPase alpha-1subunit). 1Show
12ATP2B1AT2B1_HUMANPlasma membrane calcium-transporting ATPase 1 (EC 3.6.3.8) (PMCA1)(Plasma membrane calcium pump isoform 1) (Plasma membrane calciumATPase isoform 1). 1Show
13ATP2B2AT2B2_HUMANPlasma membrane calcium-transporting ATPase 2 (EC 3.6.3.8) (PMCA2)(Plasma membrane calcium pump isoform 2) (Plasma membrane calciumATPase isoform 2). 1Show
14ATP2B3AT2B3_HUMANPlasma membrane calcium-transporting ATPase 3 (EC 3.6.3.8) (PMCA3)(Plasma membrane calcium pump isoform 3) (Plasma membrane calciumATPase isoform 3). 1Show
15ATP2B4AT2B4_HUMANPlasma membrane calcium-transporting ATPase 4 (EC 3.6.3.8) (PMCA4)(Plasma membrane calcium pump isoform 4) (Plasma membrane calciumATPase isoform 4) (Matrix-remodeling-associated protein 1). 1Show
16ATF2ATF2_HUMANCyclic AMP-dependent transcription factor ATF-2 (Activatingtranscription factor 2) (cAMP response element-binding protein CRE-BP1) (HB16). 2Show
17BCL2BCL2_HUMANApoptosis regulator Bcl-2. 1Show
18BDKRB2BKRB2_HUMANB2 bradykinin receptor (BK-2 receptor) (B2R). 1Show
19BTBD14BBTB14_HUMANBTB/POZ domain-containing protein 14B (Nucleus accumbens-1) (NAC-1). 1Show
20CANXCALX_HUMANCalnexin precursor (Major histocompatibility complex class I antigen-binding protein p88) (p90) (IP90). 1Show
21CASRCASR_HUMANExtracellular calcium-sensing receptor precursor (CaSR) (ParathyroidCell calcium-sensing receptor) (PCaR1). 1Show
22CREBBPCBP_HUMANCREB-binding protein (EC 2.3.1.48). 1Show
23CD3GCD3G_HUMANT-cell surface glycoprotein CD3 gamma chain precursor (T-cell receptorT3 gamma chain). 1Show
24CD44CD44_HUMANCD44 antigen precursor (Phagocytic glycoprotein I) (PGP-1) (HUTCH-I)(Extracellular matrix receptor-III) (ECMR-III) (GP90 lymphocytehoming/adhesion receptor) (Hermes antigen) (Hyaluronate receptor)(Heparan sulfate proteoglycan) (Epican) (CDw44). 2Show
25PTPRCCD45_HUMANLeukocyte common antigen precursor (EC 3.1.3.48) (L-CA) (T200) (CD45antigen). 1Show
26CDKN1ACDN1A_HUMANCyclin-dependent kinase inhibitor 1 (p21) (CDK-interacting protein 1)(Melanoma differentiation-associated protein 6) (MDA-6). 2Show
27CENTA1CENA1_HUMANCentaurin-alpha-1 (Putative MAPK-activating protein PM25). 2Show
28CFTRCFTR_HUMANCystic fibrosis transmembrane conductance regulator (CFTR) (cAMP-dependent chloride channel) (ATP-binding cassette transporter sub-family C member 7). 4Show
29CNPCN37_HUMAN2',3'-cyclic-nucleotide 3'-phosphodiesterase (EC 3.1.4.37) (CNP)(CNPase). 1Show
30CORO1BCOR1B_HUMANCoronin-1B (Coronin-2). 1Show
31GJB1CXB1_HUMANGap junction beta-1 protein (Connexin-32) (Cx32) (GAP junction 28 kDaliver protein). 2Show
32PSCD1CYH1_HUMANCytohesin-1 (PH, SEC7 and coiled-coil domain-containing protein 1)(SEC7 homolog B2-1). 2Show
33PSCD2CYH2_HUMANCytohesin-2 (PH, SEC7 and coiled-coil domain-containing protein 2)(ARF nucleotide-binding site opener) (Protein ARNO) (ARF exchangefactor). 1Show
34DAB2DAB2_HUMANDisabled homolog 2 (Differentially-expressed protein 2) (DOC-2). 1Show
35DCXDCX_HUMANNeuronal migration protein doublecortin (Lissencephalin-X) (Lis-X)(Doublin). 6Show
36DDX5DDX5_HUMANProbable ATP-dependent RNA helicase DDX5 (EC 3.6.1.-) (DEAD boxprotein 5) (RNA helicase p68). 1Show
37EEF1A1EF1A1_HUMANElongation factor 1-alpha 1 (EF-1-alpha-1) (Elongation factor 1 A-1)(eEF1A-1) (Elongation factor Tu) (EF-Tu) (Leukocyte receptor clustermember 7). 1Show
38EGFREGFR_HUMANEpidermal growth factor receptor precursor (EC 2.7.10.1) (Receptortyrosine-protein kinase ErbB-1). 2Show
39EWSR1EWS_HUMANRNA-binding protein EWS (EWS oncogene) (Ewing sarcoma breakpointregion 1 protein). 2Show
40PFKFB2F262_HUMAN6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 2 (6PF-2-K/Fru-2,6-P2ASE heart-type isozyme) (PFK-2/FBPase-2) [Includes: 6-phosphofructo-2-kinase (EC 2.7.1.105); Fructose-2,6-bisphosphatase(EC 3.1.3.46)]. 1Show
41PFKFB3F263_HUMAN6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 (6PF-2-K/Fru-2,6-P2ASE brain/placenta-type isozyme) (iPFK-2) (Renal carcinomaantigen NY-REN-56) [Includes: 6-phosphofructo-2-kinase (EC 2.7.1.105);Fructose-2,6-bisphosphatase (EC 3.1.3.46)]. 1Show
42PFKFB4F264_HUMAN6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4 (6PF-2-K/Fru-2,6-P2ASE testis-type isozyme) [Includes: 6-phosphofructo-2-kinase(EC 2.7.1.105); Fructose-2,6-bisphosphatase (EC 3.1.3.46)]. 1Show
43FGAFIBA_HUMANFibrinogen alpha chain precursor [Contains: Fibrinopeptide A]. 4Show
44FSCN1FSCN1_HUMANFascin (Singed-like protein) (55 kDa actin-bundling protein) (p55). 2Show
45FYNFYN_HUMANProto-oncogene tyrosine-protein kinase Fyn (EC 2.7.10.2) (p59-Fyn)(Protooncogene Syn) (SLK). 1Show
46GABRB1GBRB1_HUMANGamma-aminobutyric acid receptor subunit beta-1 precursor (GABA(A)receptor subunit beta-1). 1Show
47GABRB2GBRB2_HUMANGamma-aminobutyric acid receptor subunit beta-2 precursor (GABA(A)receptor subunit beta-2). 1Show
48GABRG2GBRG2_HUMANGamma-aminobutyric acid receptor subunit gamma-2 precursor (GABA(A)receptor subunit gamma-2). 1Show
49GFAPGFAP_HUMANGlial fibrillary acidic protein (GFAP). 3Show
50GFPT1GFPT1_HUMANGlucosamine--fructose-6-phosphate aminotransferase [isomerizing] 1(EC 2.6.1.16) (Glutamine:fructose 6 phosphate amidotransferase 1)(Hexosephosphate aminotransferase 1) (D-fructose-6-phosphateamidotransferase 1) (GFAT 1) (GFAT1). 2Show
51PRKCSHGLU2B_HUMANGlucosidase 2 subunit beta precursor (Glucosidase II subunit beta)(Protein kinase C substrate, 60.1 kDa protein, heavy chain) (PKCSH)(80K-H protein). 4Show
52GNA15GNA15_HUMANGuanine nucleotide-binding protein alpha-15 subunit (G alpha-15) (Galpha-16). 1Show
53GNAZGNAZ_HUMANGuanine nucleotide-binding protein G(z) subunit alpha (G(x) alphachain) (Gz-alpha). 2Show
54GPSM2GPSM2_HUMANG-protein-signaling modulator 2 (Mosaic protein LGN). 1Show
55GRIA1GRIA1_HUMANGlutamate receptor 1 precursor (GluR-1) (GluR-A) (GluR-K1) (Glutamatereceptor ionotropic, AMPA 1) (AMPA-selective glutamate receptor 1). 1Show
56GRIA2GRIA2_HUMANGlutamate receptor 2 precursor (GluR-2) (GluR-B) (GluR-K2) (Glutamatereceptor ionotropic, AMPA 2) (AMPA-selective glutamate receptor 2). 1Show
57GRIA4GRIA4_HUMANGlutamate receptor 4 precursor (GluR-4) (GluR4) (GluR-D) (Glutamatereceptor ionotropic, AMPA 4) (AMPA-selective glutamate receptor 4). 2Show
58GRIK1GRIK1_HUMANGlutamate receptor, ionotropic kainate 1 precursor (Glutamate receptor5) (GluR-5) (GluR5) (Excitatory amino acid receptor 3) (EAA3). 2Show
59GRM1GRM1_HUMANMetabotropic glutamate receptor 1 precursor (mGluR1). 1Show
60RASGRP1GRP1_HUMANRAS guanyl-releasing protein 1 (Ras guanyl-releasing protein) (Calciumand DAG-regulated guanine nucleotide exchange factor II) (CalDAG-GEFII). 1Show
61GSK3AGSK3A_HUMANGlycogen synthase kinase-3 alpha (EC 2.7.11.26) (GSK-3 alpha). 1Show
62HABP4HABP4_HUMANIntracellular hyaluronan-binding protein 4 (IHABP4) (Ki-1/57intracellular antigen). 2Show
63HAND1HAND1_HUMANHeart- and neural crest derivatives-expressed protein 1(Extraembryonic tissues, heart, autonomic nervous system and neuralcrest derivatives-expressed protein 1) (eHAND). 3Show
64HES1HES1_HUMANTranscription factor HES-1 (Hairy and enhancer of split 1) (Hairy-like) (HHL) (Hairy homolog). 2Show
65HMGN1HMGN1_HUMANNon-histone chromosomal protein HMG-14 (High-mobility groupnucleosome-binding domain-containing protein 1). 2Show
66HSPB8HSPB8_HUMANHeat shock protein beta-8 (HspB8) (Alpha-crystallin C chain) (Smallstress protein-like protein HSP22) (E2-induced gene 1 protein)(Protein kinase H11). 3Show
67EIF4EIF4E_HUMANEukaryotic translation initiation factor 4E (eIF4E) (eIF-4E) (mRNAcap-binding protein) (eIF-4F 25 kDa subunit). 1Show
68IL2RAIL2RA_HUMANInterleukin-2 receptor alpha chain precursor (IL-2 receptor alphasubunit) (IL-2-RA) (IL2-RA) (p55) (TAC antigen) (CD25 antigen). 2Show
69IL7RIL7RA_HUMANInterleukin-7 receptor alpha chain precursor (IL-7R-alpha) (CD127antigen) (CDw127). 1Show
70INSRINSR_HUMANInsulin receptor precursor (EC 2.7.10.1) (IR) (CD220 antigen)[Contains: Insulin receptor subunit alpha; Insulin receptor subunitbeta]. 1Show
71ITPKAIP3KA_HUMANInositol-trisphosphate 3-kinase A (EC 2.7.1.127) (Inositol 1,4,5-trisphosphate 3-kinase A) (IP3K A) (IP3 3-kinase A). 1Show
72IQGAP1IQGA1_HUMANRas GTPase-activating-like protein IQGAP1 (p195). 2Show
73ITGB2ITB2_HUMANIntegrin beta-2 precursor (Cell surface adhesion glycoproteins LFA-1/CR3/p150,95 subunit beta) (Complement receptor C3 subunit beta)(CD18 antigen). 6Show
74KRT18K1C18_HUMANKeratin, type I cytoskeletal 18 (Cytokeratin-18) (CK-18) (Keratin-18)(K18) (Cell proliferation-inducing gene 46 protein). 1Show
75KRT20K1C20_HUMANKeratin, type I cytoskeletal 20 (Cytokeratin-20) (CK-20) (Keratin-20)(K20) (Protein IT). 1Show
76KCNE1KCNE1_HUMANPotassium voltage-gated channel subfamily E member 1 (IKs producingslow voltage-gated potassium channel subunit beta Mink) (Minimalpotassium channel) (Delayed rectifier potassium channel subunit IsK). 1Show
77KLF5KLF5_HUMANKrueppel-like factor 5 (Intestinal-enriched krueppel-like factor)(Colon krueppel-like factor) (Transcription factor BTEB2) (Basictranscription element-binding protein 2) (BTE-binding protein 2) (GC-box-binding protein 2). 1Show
78PRKD1KPCD1_HUMANSerine/threonine-protein kinase D1 (EC 2.7.11.13) (nPKC-D1) (Proteinkinase D) (Protein kinase C mu type) (nPKC-mu). 1Show
79LMNALMNA_HUMANLamin-A/C (70 kDa lamin) (Renal carcinoma antigen NY-REN-32). 7Show
80LMNB1LMNB1_HUMANLamin-B1. 2Show
81MARCKSMARCS_HUMANMyristoylated alanine-rich C-kinase substrate (MARCKS) (Protein kinaseC substrate, 80 kDa protein, light chain) (PKCSL) (80K-L protein). 8Show
82ABCB1MDR1_HUMANMultidrug resistance protein 1 (EC 3.6.3.44) (ATP-binding cassettesub-family B member 1) (P-glycoprotein 1) (CD243 antigen). 3Show
83MEP1BMEP1B_HUMANMeprin A subunit beta precursor (EC 3.4.24.18) (Endopeptidase-2) (N-benzoyl-L-tyrosyl-P-amino-benzoic acid hydrolase subunit beta) (PABApeptide hydrolase) (PPH beta). 1Show
84METMET_HUMANHepatocyte growth factor receptor precursor (EC 2.7.10.1) (HGFreceptor) (Scatter factor receptor) (SF receptor) (HGF/SF receptor)(Met proto-oncogene tyrosine kinase) (c-Met). 1Show
85MARCKSL1MRP_HUMANMARCKS-related protein (MARCKS-like protein 1) (Macrophagemyristoylated alanine-rich C kinase substrate) (Mac-MARCKS)(MacMARCKS). 1Show
86MYH9MYH9_HUMANMyosin-9 (Myosin heavy chain 9) (Myosin heavy chain, non-muscle IIa)(Non-muscle myosin heavy chain IIa) (NMMHC II-a) (NMMHC-IIA) (Cellularmyosin heavy chain, type A) (Non-muscle myosin heavy chain-A) (NMMHC-A). 1Show
87MYOD1MYOD1_HUMANMyoblast determination protein 1 (Myogenic factor 3) (Myf-3). 1Show
88MYBPC3MYPC3_HUMANMyosin-binding protein C, cardiac-type (Cardiac MyBP-C) (C-protein,cardiac muscle isoform). 3Show
89NCF4NCF4_HUMANNeutrophil cytosol factor 4 (NCF-4) (Neutrophil NADPH oxidase factor4) (p40-phox) (p40phox) (SH3 and PX domain-containing protein 4). 1Show
90NRGNNEUG_HUMANNeurogranin (Ng) (RC3). 2Show
91NFE2L2NF2L2_HUMANNuclear factor erythroid 2-related factor 2 (NF-E2-related factor 2)(NFE2-related factor 2) (Nuclear factor, erythroid derived 2, like 2)(HEBP1). 2Show
92GRIN1NMDZ1_HUMANGlutamate [NMDA] receptor subunit zeta-1 precursor (N-methyl-D-aspartate receptor subunit NR1). 8Show
93NOS1NOS1_HUMANNitric oxide synthase, brain (EC 1.14.13.39) (NOS type I) (NeuronalNOS) (N-NOS) (nNOS) (Constitutive NOS) (NC-NOS) (bNOS). 1Show
94NPM1NPM_HUMANNucleophosmin (NPM) (Nucleolar phosphoprotein B23) (Numatrin)(Nucleolar protein NO38). 1Show
95SLC34A1NPT2A_HUMANSodium-dependent phosphate transport protein 2A (Sodium/phosphatecotransporter 2A) (Na(+)/Pi cotransporter 2A) (Sodium-phosphatetransport protein 2A) (Na(+)-dependent phosphate cotransporter 2A)(NaPi-2a) (Solute carrier family 34 member 1) (NaPi-3). 1Show
96OCLNOCLN_HUMANOccludin. 1Show
97OPRD1OPRD_HUMANDelta-type opioid receptor (DOR-1). 1Show
98PTGER4PE2R4_HUMANProstaglandin E2 receptor EP4 subtype (Prostanoid EP4 receptor) (PGEreceptor, EP4 subtype). 6Show
99PEA15PEA15_HUMANAstrocytic phosphoprotein PEA-15 (Phosphoprotein enriched in diabetes)(PED). 1Show
100PLCB1PLCB1_HUMAN1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase beta-1(EC 3.1.4.11) (Phosphoinositide phospholipase C) (Phospholipase C-beta-1) (PLC-beta-1) (PLC-I) (PLC-154). 2Show
101PLEKPLEK_HUMANPleckstrin (Platelet p47 protein). 5Show
102FXYD1PLM_HUMANPhospholemman precursor (FXYD domain-containing ion transportregulator 1). 1Show
103PLSCR1PLS1_HUMANPhospholipid scramblase 1 (PL scramblase 1) (Ca(2+)-dependentphospholipid scramblase 1) (Erythrocyte phospholipid scramblase)(MmTRA1b). 1Show
104PLSCR2PLS2_HUMANPhospholipid scramblase 2 (PL scramblase 2) (Ca(2+)-dependentphospholipid scramblase 2). 1Show
105PSEN1PSN1_HUMANPresenilin-1 (EC 3.4.23.-) (PS-1) (Protein S182) [Contains:Presenilin-1 NTF subunit; Presenilin-1 CTF subunit; Presenilin-1 CTF12(PS1-CTF12)]. 1Show
106PTPN12PTN12_HUMANTyrosine-protein phosphatase non-receptor type 12 (EC 3.1.3.48)(Protein-tyrosine phosphatase G1) (PTPG1) (PTP-PEST). 2Show
107PTPN1PTN1_HUMANTyrosine-protein phosphatase non-receptor type 1 (EC 3.1.3.48)(Protein-tyrosine phosphatase 1B) (PTP-1B). 2Show
108RAF1RAF1_HUMANRAF proto-oncogene serine/threonine-protein kinase (EC 2.7.11.1) (Raf-1) (C-RAF) (cRaf). 3Show
109RGS19RGS19_HUMANRegulator of G-protein signaling 19 (RGS19) (G-alpha-interactingprotein) (GAIP). 2Show
110RGS1RGS1_HUMANRegulator of G-protein signaling 1 (RGS1) (Early response protein1R20) (B-cell activation protein BL34). 3Show
111SDC2SDC2_HUMANSyndecan-2 precursor (SYND2) (Fibroglycan) (Heparan sulfateproteoglycan core protein) (HSPG). 2Show
112TAGLNTAGL_HUMANTransgelin (Smooth muscle protein 22-alpha) (SM22-alpha) (WS3-10) (22kDa actin-binding protein). 1Show
113TCEAL1TCAL1_HUMANTranscription elongation factor A protein-like 1 (TCEA-like protein 1)(Transcription elongation factor S-II protein-like 1) (Nuclearphosphoprotein p21/SIIR). 2Show
114TFRCTFR1_HUMANTransferrin receptor protein 1 (TfR1) (TR) (TfR) (Trfr) (CD71 antigen)(T9) (p90) [Contains: Transferrin receptor protein 1, serum form(sTfR)]. 1Show
115F3TF_HUMANTissue factor precursor (TF) (Coagulation factor III) (Thromboplastin)(CD142 antigen). 2Show
116TOP2ATOP2A_HUMANDNA topoisomerase 2-alpha (EC 5.99.1.3) (DNA topoisomerase II, alphaisozyme). 1Show
117TRPM4TRPM4_HUMANTransient receptor potential cation channel subfamily M member 4 (Longtransient receptor potential channel 4) (hTRPM4) (Melastatin-4)(Calcium-activated non-selective cation channel 1). 2Show
118VASPVASP_HUMANVasodilator-stimulated phosphoprotein (VASP). 1Show
119VIMVIME_HUMANVimentin. 10Show
120VPS72VPS72_HUMANVacuolar protein sorting-associated protein 72 homolog (Transcriptionfactor-like 1) (Protein YL-1). 1Show
121XKXK_HUMANMembrane transport protein XK (Kx antigen) (Kell complex 37 kDacomponent) (XK-related protein 1). 1Show