Regulatory Network in Protein Phosphorylation
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Kinase: PKCe(PKC epsilon) protein kinase C, epsilon

Group: AGC      Family: PKC      Subfamily: Eta

Description: protein kinase C, epsilon

Gene Symbol: PRKCE

Synonyms: MGC125656, MGC125657, PKCE, nPKC-epsilon

UniprotKB/SwissProt: KPCE_HUMAN (Q02156)

Function: This is calcium-independent, phospholipid-dependent, serine- and threonine-specific enzyme. PKC is activated by diacylglycerol which in turn phosphorylates a range of cellular proteins. PKC also serves as the receptor for phorbol esters, a class of tumor promoters.

Subcellular Localization:

Protein Domain:

The substrate proteins of kinase PKCe(PKC epsilon)

No.Gene NameUniProtKB IDProtein DescriptionNumber of kinase-specific phosphorylation sitesView
1SLC4A3B3A3_HUMANAnion exchange protein 3 (Neuronal band 3-like protein) (Solutecarrier family 4 member 3) (Cardiac/brain band 3-like protein)(CAE3/BAE3). 2Show
2CENTA1CENA1_HUMANCentaurin-alpha-1 (Putative MAPK-activating protein PM25). 2Show
3GJA1CXA1_HUMANGap junction alpha-1 protein (Connexin-43) (Cx43) (Gap junction 43 kDaheart protein). 1Show
4IQGAP1IQGA1_HUMANRas GTPase-activating-like protein IQGAP1 (p195). 1Show
5KRT18K1C18_HUMANKeratin, type I cytoskeletal 18 (Cytokeratin-18) (CK-18) (Keratin-18)(K18) (Cell proliferation-inducing gene 46 protein). 3Show
6PRKCEKPCE_HUMANProtein kinase C epsilon type (EC (nPKC-epsilon). 3Show
7RPS6KB2KS6B2_HUMANRibosomal protein S6 kinase beta-2 (EC (S6K2) (70 kDaribosomal protein S6 kinase 2) (p70-S6KB) (p70 ribosomal S6 kinasebeta) (p70 S6Kbeta) (p70 S6 kinase beta) (S6K-beta) (p70-beta) (S6kinase-related kinase) (SRK) (Serine/threonine-protein kinase 14beta). 1Show
8METMET_HUMANHepatocyte growth factor receptor precursor (EC (HGFreceptor) (Scatter factor receptor) (SF receptor) (HGF/SF receptor)(Met proto-oncogene tyrosine kinase) (c-Met). 1Show
9OPRD1OPRD_HUMANDelta-type opioid receptor (DOR-1). 1Show
10PPP1R14APP14A_HUMANProtein phosphatase 1 regulatory subunit 14A (17 kDa PKC-potentiatedinhibitory protein of PP1) (CPI-17). 2Show
11TICAM2TCAM2_HUMANTIR domain-containing adapter molecule 2 (TICAM-2) (TRIF-relatedadapter molecule) (Toll/interleukin-1 receptor domain-containingprotein) (Toll-like receptor adaptor protein 3) (Putative NF-kappa-B-activating protein 502). 1Show
12TNNI3TNNI3_HUMANTroponin I, cardiac muscle (Cardiac troponin I). 1Show
13TRPV1TRPV1_HUMANTransient receptor potential cation channel subfamily V member 1(TrpV1) (osm-9-like TRP channel 1) (OTRPC1) (Vanilloid receptor 1)(Capsaicin receptor). 6Show

The substrate proteins of kinase family PKC

 No.Gene NameUniProtKB IDProtein DescriptionNumber of kinase family-specific phosphorylated sitesView
1YWHAB1433B_HUMAN14-3-3 protein beta/alpha (Protein kinase C inhibitor protein 1)(KCIP-1) (Protein 1054). 5Show
2YWHAZ1433Z_HUMAN14-3-3 protein zeta/delta (Protein kinase C inhibitor protein 1)(KCIP-1). 1Show
3HLA-A1A01_HUMANHLA class I histocompatibility antigen, A-1 alpha chain precursor (MHCclass I antigen A*1). 1Show
4SH3BP23BP2_HUMANSH3 domain-binding protein 2 (3BP-2). 1Show
5EPB4141_HUMANProtein 4.1 (Band 4.1) (P4.1) (EPB4.1) (4.1R). 2Show
6ADRA1BADA1B_HUMANAlpha-1B adrenergic receptor (Alpha 1B-adrenoceptor) (Alpha 1B-adrenoreceptor). 5Show
7ADRA2AADA2A_HUMANAlpha-2A adrenergic receptor (Alpha-2A adrenoceptor) (Alpha-2Aadrenoreceptor) (Alpha-2AAR) (Alpha-2 adrenergic receptor subtypeC10). 2Show
8ADD1ADDA_HUMANAlpha-adducin (Erythrocyte adducin subunit alpha). 7Show
9ADD2ADDB_HUMANBeta-adducin (Erythrocyte adducin subunit beta). 7Show
10ADD3ADDG_HUMANGamma-adducin (Adducin-like protein 70). 4Show
11ADRB2ADRB2_HUMANBeta-2 adrenergic receptor (Beta-2 adrenoceptor) (Beta-2adrenoreceptor). 4Show
12AHRAHR_HUMANAryl hydrocarbon receptor precursor (Ah receptor) (AhR). 2Show
13AKT3AKT3_HUMANRAC-gamma serine/threonine-protein kinase (EC (RAC-PK-gamma)(Protein kinase Akt-3) (Protein kinase B, gamma) (PKB gamma) (STK-2). 2Show
14PAMAMD_HUMANPeptidyl-glycine alpha-amidating monooxygenase precursor (PAM)[Includes: Peptidylglycine alpha-hydroxylating monooxygenase(EC (PHM); Peptidyl-alpha-hydroxyglycine alpha-amidatinglyase (EC (Peptidylamidoglycolate lyase) (PAL)]. 4Show
15ANXA1ANXA1_HUMANAnnexin A1 (Annexin-1) (Annexin I) (Lipocortin I) (Calpactin II)(Chromobindin-9) (p35) (Phospholipase A2 inhibitory protein). 5Show
16ANXA2ANXA2_HUMANAnnexin A2 (Annexin-2) (Annexin II) (Lipocortin II) (Calpactin I heavychain) (Chromobindin-8) (p36) (Protein I) (Placental anticoagulantprotein IV) (PAP-IV). 4Show
17APLP2APLP2_HUMANAmyloid-like protein 2 precursor (Amyloid protein homolog) (APPH)(CDEI box-binding protein) (CDEBP). 2Show
18ADRBK1ARBK1_HUMANBeta-adrenergic receptor kinase 1 (EC (Beta-ARK-1) (G-protein coupled receptor kinase 2). 4Show
19ASGR2ASGR2_HUMANAsialoglycoprotein receptor 2 (ASGP-R 2) (ASGPR 2) (Hepatic lectinH2). 1Show
20ATP1A1AT1A1_HUMANSodium/potassium-transporting ATPase subunit alpha-1 precursor(EC (Sodium pump subunit alpha-1) (Na(+)/K(+) ATPase alpha-1subunit). 1Show
21ATP2B1AT2B1_HUMANPlasma membrane calcium-transporting ATPase 1 (EC (PMCA1)(Plasma membrane calcium pump isoform 1) (Plasma membrane calciumATPase isoform 1). 2Show
22ATP2B2AT2B2_HUMANPlasma membrane calcium-transporting ATPase 2 (EC (PMCA2)(Plasma membrane calcium pump isoform 2) (Plasma membrane calciumATPase isoform 2). 2Show
23ATP2B3AT2B3_HUMANPlasma membrane calcium-transporting ATPase 3 (EC (PMCA3)(Plasma membrane calcium pump isoform 3) (Plasma membrane calciumATPase isoform 3). 1Show
24ATP2B4AT2B4_HUMANPlasma membrane calcium-transporting ATPase 4 (EC (PMCA4)(Plasma membrane calcium pump isoform 4) (Plasma membrane calciumATPase isoform 4) (Matrix-remodeling-associated protein 1). 1Show
25ATF2ATF2_HUMANCyclic AMP-dependent transcription factor ATF-2 (Activatingtranscription factor 2) (cAMP response element-binding protein CRE-BP1) (HB16). 2Show
26SLC4A3B3A3_HUMANAnion exchange protein 3 (Neuronal band 3-like protein) (Solutecarrier family 4 member 3) (Cardiac/brain band 3-like protein)(CAE3/BAE3). 2Show
27BCL2BCL2_HUMANApoptosis regulator Bcl-2. 2Show
28BDKRB2BKRB2_HUMANB2 bradykinin receptor (BK-2 receptor) (B2R). 2Show
29BNC1BNC1_HUMANZinc finger protein basonuclin-1. 1Show
30BTBD14BBTB14_HUMANBTB/POZ domain-containing protein 14B (Nucleus accumbens-1) (NAC-1). 1Show
31BTKBTK_HUMANTyrosine-protein kinase BTK (EC (Bruton tyrosine kinase)(Agammaglobulinaemia tyrosine kinase) (ATK) (B-cell progenitor kinase)(BPK). 1Show
32CD163C163A_HUMANScavenger receptor cysteine-rich type 1 protein M130 precursor(Hemoglobin scavenger receptor) (CD163 antigen) [Contains: SolubleCD163 (sCD163)]. 2Show
33C5AR1C5AR_HUMANC5a anaphylatoxin chemotactic receptor (C5a-R) (C5aR) (CD88 antigen). 5Show
34CANXCALX_HUMANCalnexin precursor (Major histocompatibility complex class I antigen-binding protein p88) (p90) (IP90). 1Show
35CASP9CASP9_HUMANCaspase-9 precursor (EC (CASP-9) (ICE-like apoptoticprotease 6) (ICE-LAP6) (Apoptotic protease Mch-6) (Apoptotic protease-activating factor 3) (APAF-3) [Contains: Caspase-9 subunit p35;Caspase-9 subunit p10]. 2Show
36CASRCASR_HUMANExtracellular calcium-sensing receptor precursor (CaSR) (ParathyroidCell calcium-sensing receptor) (PCaR1). 4Show
37CBLCBL_HUMANE3 ubiquitin-protein ligase CBL (EC 6.3.2.-) (Signal transductionprotein CBL) (Proto-oncogene c-CBL) (Casitas B-lineage lymphoma proto-oncogene) (RING finger protein 55). 4Show
38CREBBPCBP_HUMANCREB-binding protein (EC 2Show
39CD226CD226_HUMANCD226 antigen precursor (DNAX accessory molecule 1) (DNAM-1). 1Show
40CD3GCD3G_HUMANT-cell surface glycoprotein CD3 gamma chain precursor (T-cell receptorT3 gamma chain). 1Show
41CD44CD44_HUMANCD44 antigen precursor (Phagocytic glycoprotein I) (PGP-1) (HUTCH-I)(Extracellular matrix receptor-III) (ECMR-III) (GP90 lymphocytehoming/adhesion receptor) (Hermes antigen) (Hyaluronate receptor)(Heparan sulfate proteoglycan) (Epican) (CDw44). 3Show
42PTPRCCD45_HUMANLeukocyte common antigen precursor (EC (L-CA) (T200) (CD45antigen). 1Show
43CD5CD5_HUMANT-cell surface glycoprotein CD5 precursor (Lymphocyte antigen T1/Leu-1) (CD5 antigen). 8Show
44CDKN1ACDN1A_HUMANCyclin-dependent kinase inhibitor 1 (p21) (CDK-interacting protein 1)(Melanoma differentiation-associated protein 6) (MDA-6). 3Show
45CENTA1CENA1_HUMANCentaurin-alpha-1 (Putative MAPK-activating protein PM25). 6Show
46CFTRCFTR_HUMANCystic fibrosis transmembrane conductance regulator (CFTR) (cAMP-dependent chloride channel) (ATP-binding cassette transporter sub-family C member 7). 6Show
47CNPCN37_HUMAN2',3'-cyclic-nucleotide 3'-phosphodiesterase (EC (CNP)(CNPase). 1Show
48CORO1BCOR1B_HUMANCoronin-1B (Coronin-2). 2Show
49CREMCREM_HUMANcAMP-responsive element modulator (Inducible cAMP early repressor)(ICER). 1Show
50CSPG4CSPG4_HUMANChondroitin sulfate proteoglycan 4 precursor (Chondroitin sulfateproteoglycan NG2) (Melanoma chondroitin sulfate proteoglycan)(Melanoma-associated chondroitin sulfate proteoglycan). 1Show
51GJA1CXA1_HUMANGap junction alpha-1 protein (Connexin-43) (Cx43) (Gap junction 43 kDaheart protein). 4Show
52GJB1CXB1_HUMANGap junction beta-1 protein (Connexin-32) (Cx32) (GAP junction 28 kDaliver protein). 4Show
53PSCD1CYH1_HUMANCytohesin-1 (PH, SEC7 and coiled-coil domain-containing protein 1)(SEC7 homolog B2-1). 5Show
54PSCD2CYH2_HUMANCytohesin-2 (PH, SEC7 and coiled-coil domain-containing protein 2)(ARF nucleotide-binding site opener) (Protein ARNO) (ARF exchangefactor). 4Show
55DAB2DAB2_HUMANDisabled homolog 2 (Differentially-expressed protein 2) (DOC-2). 4Show
56DCXDCX_HUMANNeuronal migration protein doublecortin (Lissencephalin-X) (Lis-X)(Doublin). 6Show
57DDX5DDX5_HUMANProbable ATP-dependent RNA helicase DDX5 (EC 3.6.1.-) (DEAD boxprotein 5) (RNA helicase p68). 2Show
58DGKDDGKD_HUMANDiacylglycerol kinase delta (EC (Diglyceride kinase delta)(DGK-delta) (DAG kinase delta) (130 kDa diacylglycerol kinase). 4Show
59DGKZDGKZ_HUMANDiacylglycerol kinase zeta (EC (Diglyceride kinase zeta)(DGK-zeta) (DAG kinase zeta). 2Show
60DNM1DYN1_HUMANDynamin-1 (EC 1Show
61EEF1A1EF1A1_HUMANElongation factor 1-alpha 1 (EF-1-alpha-1) (Elongation factor 1 A-1)(eEF1A-1) (Elongation factor Tu) (EF-Tu) (Leukocyte receptor clustermember 7). 2Show
62EGFREGFR_HUMANEpidermal growth factor receptor precursor (EC (Receptortyrosine-protein kinase ErbB-1). 3Show
63EP300EP300_HUMANHistone acetyltransferase p300 (EC (E1A-associated proteinp300). 2Show
64EWSR1EWS_HUMANRNA-binding protein EWS (EWS oncogene) (Ewing sarcoma breakpointregion 1 protein). 3Show
65VIL2EZRI_HUMANEzrin (p81) (Cytovillin) (Villin-2). 1Show
66PFKFB2F262_HUMAN6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 2 (6PF-2-K/Fru-2,6-P2ASE heart-type isozyme) (PFK-2/FBPase-2) [Includes: 6-phosphofructo-2-kinase (EC; Fructose-2,6-bisphosphatase(EC]. 2Show
67PFKFB3F263_HUMAN6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 (6PF-2-K/Fru-2,6-P2ASE brain/placenta-type isozyme) (iPFK-2) (Renal carcinomaantigen NY-REN-56) [Includes: 6-phosphofructo-2-kinase (EC;Fructose-2,6-bisphosphatase (EC]. 1Show
68PFKFB4F264_HUMAN6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4 (6PF-2-K/Fru-2,6-P2ASE testis-type isozyme) [Includes: 6-phosphofructo-2-kinase(EC; Fructose-2,6-bisphosphatase (EC]. 1Show
69FGF2FGF2_HUMANHeparin-binding growth factor 2 precursor (HBGF-2) (Basic fibroblastgrowth factor) (BFGF) (Prostatropin). 1Show
70FGAFIBA_HUMANFibrinogen alpha chain precursor [Contains: Fibrinopeptide A]. 4Show
71FSCN1FSCN1_HUMANFascin (Singed-like protein) (55 kDa actin-bundling protein) (p55). 3Show
72FUSFUS_HUMANRNA-binding protein FUS (Oncogene FUS) (Oncogene TLS) (Translocated inliposarcoma protein) (POMp75) (75 kDa DNA-pairing protein). 1Show
73FYNFYN_HUMANProto-oncogene tyrosine-protein kinase Fyn (EC (p59-Fyn)(Protooncogene Syn) (SLK). 1Show
74GABRB1GBRB1_HUMANGamma-aminobutyric acid receptor subunit beta-1 precursor (GABA(A)receptor subunit beta-1). 1Show
75GABRB2GBRB2_HUMANGamma-aminobutyric acid receptor subunit beta-2 precursor (GABA(A)receptor subunit beta-2). 1Show
76GABRG2GBRG2_HUMANGamma-aminobutyric acid receptor subunit gamma-2 precursor (GABA(A)receptor subunit gamma-2). 3Show
77GEMGEM_HUMANGTP-binding protein GEM (GTP-binding mitogen-induced T-cell protein)(RAS-like protein KIR). 1Show
78GFAPGFAP_HUMANGlial fibrillary acidic protein (GFAP). 6Show
79GFPT1GFPT1_HUMANGlucosamine--fructose-6-phosphate aminotransferase [isomerizing] 1(EC (Glutamine:fructose 6 phosphate amidotransferase 1)(Hexosephosphate aminotransferase 1) (D-fructose-6-phosphateamidotransferase 1) (GFAT 1) (GFAT1). 4Show
80PRKCSHGLU2B_HUMANGlucosidase 2 subunit beta precursor (Glucosidase II subunit beta)(Protein kinase C substrate, 60.1 kDa protein, heavy chain) (PKCSH)(80K-H protein). 4Show
81GMFBGMFB_HUMANGlia maturation factor beta (GMF-beta). 2Show
82GNA15GNA15_HUMANGuanine nucleotide-binding protein alpha-15 subunit (G alpha-15) (Galpha-16). 2Show
83GNAZGNAZ_HUMANGuanine nucleotide-binding protein G(z) subunit alpha (G(x) alphachain) (Gz-alpha). 4Show
84GPM6AGPM6A_HUMANNeuronal membrane glycoprotein M6-a (M6a). 2Show
85GPSM2GPSM2_HUMANG-protein-signaling modulator 2 (Mosaic protein LGN). 1Show
86GRIA1GRIA1_HUMANGlutamate receptor 1 precursor (GluR-1) (GluR-A) (GluR-K1) (Glutamatereceptor ionotropic, AMPA 1) (AMPA-selective glutamate receptor 1). 2Show
87GRIA2GRIA2_HUMANGlutamate receptor 2 precursor (GluR-2) (GluR-B) (GluR-K2) (Glutamatereceptor ionotropic, AMPA 2) (AMPA-selective glutamate receptor 2). 4Show
88GRIA4GRIA4_HUMANGlutamate receptor 4 precursor (GluR-4) (GluR4) (GluR-D) (Glutamatereceptor ionotropic, AMPA 4) (AMPA-selective glutamate receptor 4). 4Show
89GRIK1GRIK1_HUMANGlutamate receptor, ionotropic kainate 1 precursor (Glutamate receptor5) (GluR-5) (GluR5) (Excitatory amino acid receptor 3) (EAA3). 2Show
90GRM1GRM1_HUMANMetabotropic glutamate receptor 1 precursor (mGluR1). 2Show
91RASGRP1GRP1_HUMANRAS guanyl-releasing protein 1 (Ras guanyl-releasing protein) (Calciumand DAG-regulated guanine nucleotide exchange factor II) (CalDAG-GEFII). 1Show
92RASGRP3GRP3_HUMANRas guanyl-releasing protein 3 (Calcium and DAG-regulated guaninenucleotide exchange factor III) (Guanine nucleotide exchange factorfor Rap1). 1Show
93GSK3AGSK3A_HUMANGlycogen synthase kinase-3 alpha (EC (GSK-3 alpha). 5Show
94HABP4HABP4_HUMANIntracellular hyaluronan-binding protein 4 (IHABP4) (Ki-1/57intracellular antigen). 14Show
95HAND1HAND1_HUMANHeart- and neural crest derivatives-expressed protein 1(Extraembryonic tissues, heart, autonomic nervous system and neuralcrest derivatives-expressed protein 1) (eHAND). 6Show
96HES1HES1_HUMANTranscription factor HES-1 (Hairy and enhancer of split 1) (Hairy-like) (HHL) (Hairy homolog). 4Show
97HMGN1HMGN1_HUMANNon-histone chromosomal protein HMG-14 (High-mobility groupnucleosome-binding domain-containing protein 1). 5Show
98HMGN2HMGN2_HUMANNon-histone chromosomal protein HMG-17 (High-mobility groupnucleosome-binding domain-containing protein 2). 2Show
99HNRPKHNRPK_HUMANHeterogeneous nuclear ribonucleoprotein K (hnRNP K) (Transformationup-regulated nuclear protein) (TUNP). 3Show
100HRH1HRH1_HUMANHistamine H1 receptor. 3Show
101HSPB8HSPB8_HUMANHeat shock protein beta-8 (HspB8) (Alpha-crystallin C chain) (Smallstress protein-like protein HSP22) (E2-induced gene 1 protein)(Protein kinase H11). 5Show
102ICAM3ICAM3_HUMANIntercellular adhesion molecule 3 precursor (ICAM-3) (ICAM-R) (CD50antigen) (CDw50). 2Show
103EIF2S1IF2A_HUMANEukaryotic translation initiation factor 2 subunit 1 (Eukaryotictranslation initiation factor 2 subunit alpha) (eIF-2-alpha) (EIF-2alpha) (EIF-2A). 1Show
104EIF4EIF4E_HUMANEukaryotic translation initiation factor 4E (eIF4E) (eIF-4E) (mRNAcap-binding protein) (eIF-4F 25 kDa subunit). 4Show
105EIF6IF6_HUMANEukaryotic translation initiation factor 6 (eIF-6) (B4 integrininteractor) (CAB) (p27(BBP)) (B(2)GCN homolog). 2Show
106CHUKIKKA_HUMANInhibitor of nuclear factor kappa-B kinase subunit alpha(EC (I kappa-B kinase alpha) (IkBKA) (IKK-alpha) (IKK-A)(IkappaB kinase) (I-kappa-B kinase 1) (IKK1) (Conserved helix-loop-helix ubiquitous kinase) (Nuclear factor NF-kappa-B inhibitor kinasealpha) (NFKBIKA). 2Show
107IKBKBIKKB_HUMANInhibitor of nuclear factor kappa-B kinase subunit beta (EC beta) (IkBKB) (IKK-beta) (IKK-B) (I-kappa-B kinase2) (IKK2) (Nuclear factor NF-kappa-B inhibitor kinase beta) (NFKBIKB). 4Show
108IL2RAIL2RA_HUMANInterleukin-2 receptor alpha chain precursor (IL-2 receptor alphasubunit) (IL-2-RA) (IL2-RA) (p55) (TAC antigen) (CD25 antigen). 2Show
109IL6STIL6RB_HUMANInterleukin-6 receptor subunit beta precursor (IL-6R-beta)(Interleukin-6 signal transducer) (Membrane glycoprotein 130) (gp130)(Oncostatin-M receptor alpha subunit) (CD130 antigen) (CDw130). 3Show
110IL7RIL7RA_HUMANInterleukin-7 receptor alpha chain precursor (IL-7R-alpha) (CD127antigen) (CDw127). 1Show
111INSRINSR_HUMANInsulin receptor precursor (EC (IR) (CD220 antigen)[Contains: Insulin receptor subunit alpha; Insulin receptor subunitbeta]. 6Show
112ITPKAIP3KA_HUMANInositol-trisphosphate 3-kinase A (EC (Inositol 1,4,5-trisphosphate 3-kinase A) (IP3K A) (IP3 3-kinase A). 2Show
113IQGAP1IQGA1_HUMANRas GTPase-activating-like protein IQGAP1 (p195). 3Show
114ACO1IREB1_HUMANIron-responsive element-binding protein 1 (IRE-BP 1) (Iron regulatoryprotein 1) (IRP1) (Ferritin repressor protein) (Aconitate hydratase)(EC (Citrate hydro-lyase) (Aconitase). 2Show
115KCNJ1IRK1_HUMANATP-sensitive inward rectifier potassium channel 1 (Potassium channel,inwardly rectifying subfamily J member 1) (ATP-regulated potassiumchannel ROM-K) (Kir1.1). 2Show
116KCNJ4IRK4_HUMANInward rectifier potassium channel 4 (Potassium channel, inwardlyrectifying subfamily J member 4) (Inward rectifier K(+) channelKir2.3) (Hippocampal inward rectifier) (HIR) (HRK1) (HIRK2). 1Show
117IRS1IRS1_HUMANInsulin receptor substrate 1 (IRS-1). 7Show
118ITGB2ITB2_HUMANIntegrin beta-2 precursor (Cell surface adhesion glycoproteins LFA-1/CR3/p150,95 subunit beta) (Complement receptor C3 subunit beta)(CD18 antigen). 15Show
119ITGB4ITB4_HUMANIntegrin beta-4 precursor (GP150) (CD104 antigen). 3Show
120ITGB7ITB7_HUMANIntegrin beta-7 precursor. 2Show
121F11RJAM1_HUMANJunctional adhesion molecule A precursor (JAM-A) (Junctional adhesionmolecule 1) (JAM-1) (Platelet adhesion molecule 1) (PAM-1) (PlateletF11 receptor) (CD321 antigen). 2Show
122KRT18K1C18_HUMANKeratin, type I cytoskeletal 18 (Cytokeratin-18) (CK-18) (Keratin-18)(K18) (Cell proliferation-inducing gene 46 protein). 4Show
123KRT20K1C20_HUMANKeratin, type I cytoskeletal 20 (Cytokeratin-20) (CK-20) (Keratin-20)(K20) (Protein IT). 1Show
124KRT8K2C8_HUMANKeratin, type II cytoskeletal 8 (Cytokeratin-8) (CK-8) (Keratin-8)(K8). 1Show
125KCNC4KCNC4_HUMANPotassium voltage-gated channel subfamily C member 4 (Voltage-gatedpotassium channel subunit Kv3.4) (KSHIIIC). 4Show
126KCNE1KCNE1_HUMANPotassium voltage-gated channel subfamily E member 1 (IKs producingslow voltage-gated potassium channel subunit beta Mink) (Minimalpotassium channel) (Delayed rectifier potassium channel subunit IsK). 2Show
127KCNQ2KCNQ2_HUMANPotassium voltage-gated channel subfamily KQT member 2 (Voltage-gatedpotassium channel subunit Kv7.2) (Neuroblastoma-specific potassiumchannel subunit alpha KvLQT2) (KQT-like 2). 2Show
128PRKG1KGP1A_HUMANcGMP-dependent protein kinase 1, alpha isozyme (EC (CGK 1alpha) (cGKI-alpha). 1Show
129KITKIT_HUMANMast/stem cell growth factor receptor precursor (EC (SCFR)(Proto-oncogene tyrosine-protein kinase Kit) (c-kit) (CD117 antigen). 8Show
130KLF5KLF5_HUMANKrueppel-like factor 5 (Intestinal-enriched krueppel-like factor)(Colon krueppel-like factor) (Transcription factor BTEB2) (Basictranscription element-binding protein 2) (BTE-binding protein 2) (GC-box-binding protein 2). 2Show
131PRKCAKPCA_HUMANProtein kinase C alpha type (EC (PKC-alpha) (PKC-A). 2Show
132PRKCB1KPCB_HUMANProtein kinase C beta type (EC (PKC-beta) (PKC-B). 3Show
133PRKD1KPCD1_HUMANSerine/threonine-protein kinase D1 (EC (nPKC-D1) (Proteinkinase D) (Protein kinase C mu type) (nPKC-mu). 4Show
134PRKCDKPCD_HUMANProtein kinase C delta type (EC (nPKC-delta). 2Show
135PRKCEKPCE_HUMANProtein kinase C epsilon type (EC (nPKC-epsilon). 3Show
136PRKCQKPCT_HUMANProtein kinase C theta type (EC (nPKC-theta). 2Show
137PRKCZKPCZ_HUMANProtein kinase C zeta type (EC (nPKC-zeta). 2Show
138RPS6KB2KS6B2_HUMANRibosomal protein S6 kinase beta-2 (EC (S6K2) (70 kDaribosomal protein S6 kinase 2) (p70-S6KB) (p70 ribosomal S6 kinasebeta) (p70 S6Kbeta) (p70 S6 kinase beta) (S6K-beta) (p70-beta) (S6kinase-related kinase) (SRK) (Serine/threonine-protein kinase 14beta). 1Show
139LCKLCK_HUMANProto-oncogene tyrosine-protein kinase LCK (EC (p56-LCK)(Lymphocyte cell-specific protein-tyrosine kinase) (LSK) (T cell-specific protein-tyrosine kinase). 1Show
140SPNLEUK_HUMANLeukosialin precursor (Leukocyte sialoglycoprotein) (Sialophorin)(Galactoglycoprotein) (GALGP) (CD43 antigen). 1Show
141LIMK2LIMK2_HUMANLIM domain kinase 2 (EC (LIMK-2). 1Show
142LMNALMNA_HUMANLamin-A/C (70 kDa lamin) (Renal carcinoma antigen NY-REN-32). 11Show
143LMNB1LMNB1_HUMANLamin-B1. 6Show
144MARCKSMARCS_HUMANMyristoylated alanine-rich C-kinase substrate (MARCKS) (Protein kinaseC substrate, 80 kDa protein, light chain) (PKCSL) (80K-L protein). 20Show
145MARK2MARK2_HUMANSerine/threonine-protein kinase MARK2 (EC (MAP/microtubuleaffinity-regulating kinase 2) (ELKL motif kinase) (EMK1) (PAR1homolog). 2Show
146MBPMBP_HUMANMyelin basic protein (MBP) (Myelin A1 protein) (Myelin membraneencephalitogenic protein). 7Show
147ABCB1MDR1_HUMANMultidrug resistance protein 1 (EC (ATP-binding cassettesub-family B member 1) (P-glycoprotein 1) (CD243 antigen). 3Show
148MEP1BMEP1B_HUMANMeprin A subunit beta precursor (EC (Endopeptidase-2) (N-benzoyl-L-tyrosyl-P-amino-benzoic acid hydrolase subunit beta) (PABApeptide hydrolase) (PPH beta). 2Show
149METMET_HUMANHepatocyte growth factor receptor precursor (EC (HGFreceptor) (Scatter factor receptor) (SF receptor) (HGF/SF receptor)(Met proto-oncogene tyrosine kinase) (c-Met). 1Show
150MSNMOES_HUMANMoesin (Membrane-organizing extension spike protein). 2Show
151MARCKSL1MRP_HUMANMARCKS-related protein (MARCKS-like protein 1) (Macrophagemyristoylated alanine-rich C kinase substrate) (Mac-MARCKS)(MacMARCKS). 1Show
152MUC1MUC1_HUMANMucin-1 precursor (MUC-1) (Polymorphic epithelial mucin) (PEM) (PEMT)(Episialin) (Tumor-associated mucin) (Carcinoma-associated mucin)(Tumor-associated epithelial membrane antigen) (EMA) (H23AG) (Peanut-reactive urinary mucin) (PUM) (Breast carcinoma-associated antigenDF3) (CD227 antigen) [Contains: Mucin-1 alpha subunit (MUC1-alpha)(MUC1-NT); Mucin-1 beta subunit (MUC1-beta) (MUC1-CT)]. 4Show
153MYH9MYH9_HUMANMyosin-9 (Myosin heavy chain 9) (Myosin heavy chain, non-muscle IIa)(Non-muscle myosin heavy chain IIa) (NMMHC II-a) (NMMHC-IIA) (Cellularmyosin heavy chain, type A) (Non-muscle myosin heavy chain-A) (NMMHC-A). 1Show
154MYOD1MYOD1_HUMANMyoblast determination protein 1 (Myogenic factor 3) (Myf-3). 2Show
155MYBPC3MYPC3_HUMANMyosin-binding protein C, cardiac-type (Cardiac MyBP-C) (C-protein,cardiac muscle isoform). 3Show
156NCF1NCF1_HUMANNeutrophil cytosol factor 1 (NCF-1) (Neutrophil NADPH oxidase factor1) (47 kDa neutrophil oxidase factor) (p47-phox) (NCF-47K) (47 kDaautosomal chronic granulomatous disease protein) (Nox organizer 2)(Nox-organizing protein 2) (SH3 and PX domain-containing protein 1A). 7Show
157NCF4NCF4_HUMANNeutrophil cytosol factor 4 (NCF-4) (Neutrophil NADPH oxidase factor4) (p40-phox) (p40phox) (SH3 and PX domain-containing protein 4). 3Show
158NRGNNEUG_HUMANNeurogranin (Ng) (RC3). 5Show
159GAP43NEUM_HUMANNeuromodulin (Axonal membrane protein GAP-43) (Growth-associatedprotein 43) (PP46) (Neural phosphoprotein B-50). 1Show
160NFE2L2NF2L2_HUMANNuclear factor erythroid 2-related factor 2 (NF-E2-related factor 2)(NFE2-related factor 2) (Nuclear factor, erythroid derived 2, like 2)(HEBP1). 3Show
161NFATC1NFAC1_HUMANNuclear factor of activated T-cells, cytoplasmic 1 (NFAT transcriptioncomplex cytosolic component) (NF-ATc1) (NF-ATc) (NFATc). 4Show
162SLC9A3R1NHERF_HUMANEzrin-radixin-moesin-binding phosphoprotein 50 (EBP50) (Na(+)/H(+)exchange regulatory cofactor NHE-RF) (NHERF-1) (Regulatory cofactor ofNa(+)/H(+) exchanger) (Sodium-hydrogen exchanger regulatory factor 1)(Solute carrier family 9 isoform A3 regulatory factor 1). 1Show
163GRIN2ANMDE1_HUMANGlutamate [NMDA] receptor subunit epsilon-1 precursor (N-methyl D-aspartate receptor subtype 2A) (NR2A) (NMDAR2A) (hNR2A). 1Show
164GRIN2BNMDE2_HUMANGlutamate [NMDA] receptor subunit epsilon-2 precursor (N-methyl D-aspartate receptor subtype 2B) (NR2B) (NMDAR2B) (N-methyl-D-aspartatereceptor subunit 3) (NR3) (hNR3). 8Show
165GRIN1NMDZ1_HUMANGlutamate [NMDA] receptor subunit zeta-1 precursor (N-methyl-D-aspartate receptor subunit NR1). 8Show
166NOS1NOS1_HUMANNitric oxide synthase, brain (EC (NOS type I) (NeuronalNOS) (N-NOS) (nNOS) (Constitutive NOS) (NC-NOS) (bNOS). 2Show
167NPM1NPM_HUMANNucleophosmin (NPM) (Nucleolar phosphoprotein B23) (Numatrin)(Nucleolar protein NO38). 1Show
168SLC34A1NPT2A_HUMANSodium-dependent phosphate transport protein 2A (Sodium/phosphatecotransporter 2A) (Na(+)/Pi cotransporter 2A) (Sodium-phosphatetransport protein 2A) (Na(+)-dependent phosphate cotransporter 2A)(NaPi-2a) (Solute carrier family 34 member 1) (NaPi-3). 1Show
169TBXA2RO75228_HUMANTA2R_HUMAN, BETA ISOFORM (Thromboxane A2 receptor, isoform CRA_a). 1Show
170OCLNOCLN_HUMANOccludin. 4Show
171OPRD1OPRD_HUMANDelta-type opioid receptor (DOR-1). 4Show
172RHOOPSD_HUMANRhodopsin (Opsin-2). 2Show
173SPP1OSTP_HUMANOsteopontin precursor (Bone sialoprotein 1) (Secreted phosphoprotein1) (SPP-1) (Urinary stone protein) (Nephropontin) (Uropontin). 1Show
174TP53P53_HUMANCellular tumor antigen p53 (Tumor suppressor p53) (Phosphoprotein p53)(Antigen NY-CO-13). 2Show
175PA2G4PA2G4_HUMANProliferation-associated protein 2G4 (Cell cycle protein p38-2G4homolog) (hG4-1) (ErbB3-binding protein 1). 6Show
176PTGER4PE2R4_HUMANProstaglandin E2 receptor EP4 subtype (Prostanoid EP4 receptor) (PGEreceptor, EP4 subtype). 6Show
177PEA15PEA15_HUMANAstrocytic phosphoprotein PEA-15 (Phosphoprotein enriched in diabetes)(PED). 2Show
178PEBP1PEBP1_HUMANPhosphatidylethanolamine-binding protein 1 (PEBP-1) (Prostatic-bindingprotein) (HCNPpp) (Neuropolypeptide h3) (Raf kinase inhibitor protein)(RKIP) [Contains: Hippocampal cholinergic neurostimulating peptide(HCNP)]. 6Show
179PTGIRPI2R_HUMANProstacyclin receptor (Prostanoid IP receptor) (PGI receptor)(Prostaglandin I2 receptor). 2Show
180PITPNAPIPNA_HUMANPhosphatidylinositol transfer protein alpha isoform (PtdIns transferprotein alpha) (PtdInsTP) (PI-TP-alpha). 1Show
181PLCB1PLCB1_HUMAN1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase beta-1(EC (Phosphoinositide phospholipase C) (Phospholipase C-beta-1) (PLC-beta-1) (PLC-I) (PLC-154). 4Show
182PLCB3PLCB3_HUMAN1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase beta-3(EC (Phosphoinositide phospholipase C) (Phospholipase C-beta-3) (PLC-beta-3). 1Show
183PLCG1PLCG1_HUMAN1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma-1(EC (Phosphoinositide phospholipase C) (PLC-gamma-1)(Phospholipase C-gamma-1) (PLC-II) (PLC-148). 1Show
184PLD1PLD1_HUMANPhospholipase D1 (EC (PLD 1) (Choline phosphatase 1)(Phosphatidylcholine-hydrolyzing phospholipase D1) (hPLD1). 3Show
185PLD2PLD2_HUMANPhospholipase D2 (EC (PLD 2) (Choline phosphatase 2)(Phosphatidylcholine-hydrolyzing phospholipase D2) (PLD1C) (hPLD2). 2Show
186PLEKPLEK_HUMANPleckstrin (Platelet p47 protein). 5Show
187FXYD1PLM_HUMANPhospholemman precursor (FXYD domain-containing ion transportregulator 1). 1Show
188PLSCR1PLS1_HUMANPhospholipid scramblase 1 (PL scramblase 1) (Ca(2+)-dependentphospholipid scramblase 1) (Erythrocyte phospholipid scramblase)(MmTRA1b). 2Show
189PLSCR2PLS2_HUMANPhospholipid scramblase 2 (PL scramblase 2) (Ca(2+)-dependentphospholipid scramblase 2). 1Show
190PPP1R14APP14A_HUMANProtein phosphatase 1 regulatory subunit 14A (17 kDa PKC-potentiatedinhibitory protein of PP1) (CPI-17). 4Show
191PPP1R14DPP14D_HUMANProtein phosphatase 1 regulatory subunit 14D (Gastrointestinal andbrain-specific PP1-inhibitory protein 1) (GBPI-1). 1Show
192PSEN1PSN1_HUMANPresenilin-1 (EC 3.4.23.-) (PS-1) (Protein S182) [Contains:Presenilin-1 NTF subunit; Presenilin-1 CTF subunit; Presenilin-1 CTF12(PS1-CTF12)]. 3Show
193PTPN11PTN11_HUMANTyrosine-protein phosphatase non-receptor type 11 (EC phosphatase 2C) (PTP-2C) (PTP-1D) (SH-PTP3) (SH-PTP2) (SHP-2) (Shp2). 3Show
194PTPN12PTN12_HUMANTyrosine-protein phosphatase non-receptor type 12 (EC phosphatase G1) (PTPG1) (PTP-PEST). 4Show
195PTPN1PTN1_HUMANTyrosine-protein phosphatase non-receptor type 1 (EC phosphatase 1B) (PTP-1B). 2Show
196PTPN6PTN6_HUMANTyrosine-protein phosphatase non-receptor type 6 (EC phosphatase 1C) (PTP-1C) (Hematopoietic cellprotein-tyrosine phosphatase) (SH-PTP1) (Protein-tyrosine phosphataseSHP-1). 2Show
197PTPRAPTPRA_HUMANReceptor-type tyrosine-protein phosphatase alpha precursor(EC (Protein-tyrosine phosphatase alpha) (R-PTP-alpha). 6Show
198RRADRAD_HUMANGTP-binding protein RAD (RAS associated with diabetes) (RAD1). 8Show
199RAF1RAF1_HUMANRAF proto-oncogene serine/threonine-protein kinase (EC (Raf-1) (C-RAF) (cRaf). 4Show
200RGS19RGS19_HUMANRegulator of G-protein signaling 19 (RGS19) (G-alpha-interactingprotein) (GAIP). 4Show
201RGS1RGS1_HUMANRegulator of G-protein signaling 1 (RGS1) (Early response protein1R20) (B-cell activation protein BL34). 3Show
202RGS7RGS7_HUMANRegulator of G-protein signaling 7 (RGS7). 2Show
203RPL10RL10_HUMAN60S ribosomal protein L10 (Protein QM) (Tumor suppressor QM) (Lamininreceptor homolog). 2Show
204RPS6RS6_HUMAN40S ribosomal protein S6 (Phosphoprotein NP33). 2Show
205SDC2SDC2_HUMANSyndecan-2 precursor (SYND2) (Fibroglycan) (Heparan sulfateproteoglycan core protein) (HSPG). 8Show
206SDC4SDC4_HUMANSyndecan-4 precursor (SYND4) (Amphiglycan) (Ryudocan core protein). 2Show
207SHC1SHC1_HUMANSHC-transforming protein 1 (SH2 domain protein C1) (Src homology 2domain-containing-transforming protein C1). 1Show
208SNAP23SNP23_HUMANSynaptosomal-associated protein 23 (SNAP-23) (Vesicle-membrane fusionprotein SNAP-23). 6Show
209SNAP25SNP25_HUMANSynaptosomal-associated protein 25 (SNAP-25) (Synaptosomal-associated25 kDa protein) (Super protein) (SUP). 2Show
210SPAG1SPAG1_HUMANSperm-associated antigen 1 (Infertility-related sperm protein Spag-1)(HSD-3.8). 1Show
211SRCSRC_HUMANProto-oncogene tyrosine-protein kinase Src (EC (p60-Src) (c-Src) (pp60c-src). 1Show
212SRFSRF_HUMANSerum response factor (SRF). 1Show
213STAT1STAT1_HUMANSignal transducer and activator of transcription 1-alpha/beta(Transcription factor ISGF-3 components p91/p84). 1Show
214STAT3STAT3_HUMANSignal transducer and activator of transcription 3 (Acute-phaseresponse factor). 2Show
215STK39STK39_HUMANSTE20/SPS1-related proline-alanine-rich protein kinase (EC kinase) (Serine/threonine-protein kinase 39) (DCHT). 4Show
216STMN1STMN1_HUMANStathmin (Phosphoprotein p19) (pp19) (Oncoprotein 18) (Op18)(Leukemia-associated phosphoprotein p18) (pp17) (Prosolin)(Metablastin) (Protein Pr22). 2Show
217STXBP1STXB1_HUMANSyntaxin-binding protein 1 (Unc-18 homolog) (Unc-18A) (Unc-18-1) (N-Sec1) (p67). 12Show
218TACSTD2TACD2_HUMANTumor-associated calcium signal transducer 2 precursor (Pancreaticcarcinoma marker protein GA733-1) (Cell surface glycoprotein Trop-2). 1Show
219TAGLNTAGL_HUMANTransgelin (Smooth muscle protein 22-alpha) (SM22-alpha) (WS3-10) (22kDa actin-binding protein). 2Show
220MAPTTAU_HUMANMicrotubule-associated protein tau (Neurofibrillary tangle protein)(Paired helical filament-tau) (PHF-tau). 2Show
221TCEAL1TCAL1_HUMANTranscription elongation factor A protein-like 1 (TCEA-like protein 1)(Transcription elongation factor S-II protein-like 1) (Nuclearphosphoprotein p21/SIIR). 2Show
222TICAM2TCAM2_HUMANTIR domain-containing adapter molecule 2 (TICAM-2) (TRIF-relatedadapter molecule) (Toll/interleukin-1 receptor domain-containingprotein) (Toll-like receptor adaptor protein 3) (Putative NF-kappa-B-activating protein 502). 1Show
223RELATF65_HUMANTranscription factor p65 (Nuclear factor NF-kappa-B p65 subunit). 2Show
224TFRCTFR1_HUMANTransferrin receptor protein 1 (TfR1) (TR) (TfR) (Trfr) (CD71 antigen)(T9) (p90) [Contains: Transferrin receptor protein 1, serum form(sTfR)]. 1Show
225F3TF_HUMANTissue factor precursor (TF) (Coagulation factor III) (Thromboplastin)(CD142 antigen). 2Show
226THOC5THOC5_HUMANTHO complex subunit 5 homolog (NF2/meningioma region protein pK1.3)(Placental protein 39.2). 4Show
227TNNI3TNNI3_HUMANTroponin I, cardiac muscle (Cardiac troponin I). 7Show
228TNNT2TNNT2_HUMANTroponin T, cardiac muscle (TnTc) (Cardiac muscle troponin T) (cTnT). 2Show
229TOP2ATOP2A_HUMANDNA topoisomerase 2-alpha (EC (DNA topoisomerase II, alphaisozyme). 5Show
230TRPC3TRPC3_HUMANShort transient receptor potential channel 3 (TrpC3) (Htrp-3) (Htrp3). 2Show
231TRPM4TRPM4_HUMANTransient receptor potential cation channel subfamily M member 4 (Longtransient receptor potential channel 4) (hTRPM4) (Melastatin-4)(Calcium-activated non-selective cation channel 1). 2Show
232TRPV1TRPV1_HUMANTransient receptor potential cation channel subfamily V member 1(TrpV1) (osm-9-like TRP channel 1) (OTRPC1) (Vanilloid receptor 1)(Capsaicin receptor). 6Show
233TRPV6TRPV6_HUMANTransient receptor potential cation channel subfamily V member 6(TrpV6) (Epithelial calcium channel 2) (ECaC2) (Calcium transportprotein 1) (CaT1) (CaT-like) (CaT-L). 3Show
234PLAUUROK_HUMANUrokinase-type plasminogen activator precursor (EC (uPA)(U-plasminogen activator) [Contains: Urokinase-type plasminogenactivator long chain A; Urokinase-type plasminogen activator shortchain A; Urokinase-type plasminogen activator chain B]. 2Show
235VASPVASP_HUMANVasodilator-stimulated phosphoprotein (VASP). 1Show
236VIMVIME_HUMANVimentin. 18Show
237VCLVINC_HUMANVinculin (Metavinculin). 6Show
238VPS72VPS72_HUMANVacuolar protein sorting-associated protein 72 homolog (Transcriptionfactor-like 1) (Protein YL-1). 1Show
239VTNVTNC_HUMANVitronectin precursor (Serum-spreading factor) (S-protein) (V75)[Contains: Vitronectin V65 subunit; Vitronectin V10 subunit;Somatomedin-B]. 3Show
240WIPF1WIPF1_HUMANWAS/WASL-interacting protein family member 1 (Wiskott-Aldrich syndromeprotein-interacting protein) (WASP-interacting protein) (PRPL-2protein). 2Show
241WWC1WWC1_HUMANProtein WWC1 (WW domain-containing protein 1) (Kidney and brainprotein) (KIBRA) (HBeAg-binding protein 3). 2Show
242XKXK_HUMANMembrane transport protein XK (Kx antigen) (Kell complex 37 kDacomponent) (XK-related protein 1). 1Show