Regulatory Network in Protein Phosphorylation
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Kinase: PKCg protein kinase C, gamma

Group: AGC      Family: PKC      Subfamily: Alpha

Description: protein kinase C, gamma

Gene Symbol: PRKCG

Synonyms: MGC57564, PKC-gamma, PKCC, PKCG, SCA14

UniprotKB/SwissProt: KPCG_HUMAN (P05129)

Function: This is a calcium-activated, phospholipid-dependent, serine- and threonine-specific enzyme. PKC is activated by diacylglycerol which in turn phosphorylates a range of cellular proteins. PKC also serves as the receptor for phorbol esters, a class of tumor promoters.

Subcellular Localization:

Protein Domain:

The substrate proteins of kinase PKCg

No.Gene NameUniProtKB IDProtein DescriptionNumber of kinase-specific phosphorylation sitesView
1ADRBK1ARBK1_HUMANBeta-adrenergic receptor kinase 1 (EC (Beta-ARK-1) (G-protein coupled receptor kinase 2). 1Show
2CASRCASR_HUMANExtracellular calcium-sensing receptor precursor (CaSR) (ParathyroidCell calcium-sensing receptor) (PCaR1). 1Show
3CD5CD5_HUMANT-cell surface glycoprotein CD5 precursor (Lymphocyte antigen T1/Leu-1) (CD5 antigen). 2Show
4GJA1CXA1_HUMANGap junction alpha-1 protein (Connexin-43) (Cx43) (Gap junction 43 kDaheart protein). 1Show
5PSCD2CYH2_HUMANCytohesin-2 (PH, SEC7 and coiled-coil domain-containing protein 2)(ARF nucleotide-binding site opener) (Protein ARNO) (ARF exchangefactor). 1Show
6DAB2DAB2_HUMANDisabled homolog 2 (Differentially-expressed protein 2) (DOC-2). 1Show
7GSK3AGSK3A_HUMANGlycogen synthase kinase-3 alpha (EC (GSK-3 alpha). 1Show
8HABP4HABP4_HUMANIntracellular hyaluronan-binding protein 4 (IHABP4) (Ki-1/57intracellular antigen). 2Show
9EIF4EIF4E_HUMANEukaryotic translation initiation factor 4E (eIF4E) (eIF-4E) (mRNAcap-binding protein) (eIF-4F 25 kDa subunit). 1Show
10IRS1IRS1_HUMANInsulin receptor substrate 1 (IRS-1). 1Show
11KCNC4KCNC4_HUMANPotassium voltage-gated channel subfamily C member 4 (Voltage-gatedpotassium channel subunit Kv3.4) (KSHIIIC). 4Show
12RPS6KB2KS6B2_HUMANRibosomal protein S6 kinase beta-2 (EC (S6K2) (70 kDaribosomal protein S6 kinase 2) (p70-S6KB) (p70 ribosomal S6 kinasebeta) (p70 S6Kbeta) (p70 S6 kinase beta) (S6K-beta) (p70-beta) (S6kinase-related kinase) (SRK) (Serine/threonine-protein kinase 14beta). 1Show
13NRGNNEUG_HUMANNeurogranin (Ng) (RC3). 1Show
14GRIN2BNMDE2_HUMANGlutamate [NMDA] receptor subunit epsilon-2 precursor (N-methyl D-aspartate receptor subtype 2B) (NR2B) (NMDAR2B) (N-methyl-D-aspartatereceptor subunit 3) (NR3) (hNR3). 2Show
15OCLNOCLN_HUMANOccludin. 1Show
16PA2G4PA2G4_HUMANProliferation-associated protein 2G4 (Cell cycle protein p38-2G4homolog) (hG4-1) (ErbB3-binding protein 1). 2Show
17PEBP1PEBP1_HUMANPhosphatidylethanolamine-binding protein 1 (PEBP-1) (Prostatic-bindingprotein) (HCNPpp) (Neuropolypeptide h3) (Raf kinase inhibitor protein)(RKIP) [Contains: Hippocampal cholinergic neurostimulating peptide(HCNP)]. 1Show
18SDC2SDC2_HUMANSyndecan-2 precursor (SYND2) (Fibroglycan) (Heparan sulfateproteoglycan core protein) (HSPG). 2Show
19STXBP1STXB1_HUMANSyntaxin-binding protein 1 (Unc-18 homolog) (Unc-18A) (Unc-18-1) (N-Sec1) (p67). 4Show
20TOP2ATOP2A_HUMANDNA topoisomerase 2-alpha (EC (DNA topoisomerase II, alphaisozyme). 1Show
21VTNVTNC_HUMANVitronectin precursor (Serum-spreading factor) (S-protein) (V75)[Contains: Vitronectin V65 subunit; Vitronectin V10 subunit;Somatomedin-B]. 1Show

The substrate proteins of kinase family PKC

 No.Gene NameUniProtKB IDProtein DescriptionNumber of kinase family-specific phosphorylated sitesView
1YWHAB1433B_HUMAN14-3-3 protein beta/alpha (Protein kinase C inhibitor protein 1)(KCIP-1) (Protein 1054). 5Show
2YWHAZ1433Z_HUMAN14-3-3 protein zeta/delta (Protein kinase C inhibitor protein 1)(KCIP-1). 1Show
3HLA-A1A01_HUMANHLA class I histocompatibility antigen, A-1 alpha chain precursor (MHCclass I antigen A*1). 1Show
4SH3BP23BP2_HUMANSH3 domain-binding protein 2 (3BP-2). 1Show
5EPB4141_HUMANProtein 4.1 (Band 4.1) (P4.1) (EPB4.1) (4.1R). 2Show
6ADRA1BADA1B_HUMANAlpha-1B adrenergic receptor (Alpha 1B-adrenoceptor) (Alpha 1B-adrenoreceptor). 5Show
7ADRA2AADA2A_HUMANAlpha-2A adrenergic receptor (Alpha-2A adrenoceptor) (Alpha-2Aadrenoreceptor) (Alpha-2AAR) (Alpha-2 adrenergic receptor subtypeC10). 2Show
8ADD1ADDA_HUMANAlpha-adducin (Erythrocyte adducin subunit alpha). 7Show
9ADD2ADDB_HUMANBeta-adducin (Erythrocyte adducin subunit beta). 7Show
10ADD3ADDG_HUMANGamma-adducin (Adducin-like protein 70). 4Show
11ADRB2ADRB2_HUMANBeta-2 adrenergic receptor (Beta-2 adrenoceptor) (Beta-2adrenoreceptor). 4Show
12AHRAHR_HUMANAryl hydrocarbon receptor precursor (Ah receptor) (AhR). 2Show
13AKT3AKT3_HUMANRAC-gamma serine/threonine-protein kinase (EC (RAC-PK-gamma)(Protein kinase Akt-3) (Protein kinase B, gamma) (PKB gamma) (STK-2). 2Show
14PAMAMD_HUMANPeptidyl-glycine alpha-amidating monooxygenase precursor (PAM)[Includes: Peptidylglycine alpha-hydroxylating monooxygenase(EC (PHM); Peptidyl-alpha-hydroxyglycine alpha-amidatinglyase (EC (Peptidylamidoglycolate lyase) (PAL)]. 4Show
15ANXA1ANXA1_HUMANAnnexin A1 (Annexin-1) (Annexin I) (Lipocortin I) (Calpactin II)(Chromobindin-9) (p35) (Phospholipase A2 inhibitory protein). 5Show
16ANXA2ANXA2_HUMANAnnexin A2 (Annexin-2) (Annexin II) (Lipocortin II) (Calpactin I heavychain) (Chromobindin-8) (p36) (Protein I) (Placental anticoagulantprotein IV) (PAP-IV). 4Show
17APLP2APLP2_HUMANAmyloid-like protein 2 precursor (Amyloid protein homolog) (APPH)(CDEI box-binding protein) (CDEBP). 2Show
18ADRBK1ARBK1_HUMANBeta-adrenergic receptor kinase 1 (EC (Beta-ARK-1) (G-protein coupled receptor kinase 2). 4Show
19ASGR2ASGR2_HUMANAsialoglycoprotein receptor 2 (ASGP-R 2) (ASGPR 2) (Hepatic lectinH2). 1Show
20ATP1A1AT1A1_HUMANSodium/potassium-transporting ATPase subunit alpha-1 precursor(EC (Sodium pump subunit alpha-1) (Na(+)/K(+) ATPase alpha-1subunit). 1Show
21ATP2B1AT2B1_HUMANPlasma membrane calcium-transporting ATPase 1 (EC (PMCA1)(Plasma membrane calcium pump isoform 1) (Plasma membrane calciumATPase isoform 1). 2Show
22ATP2B2AT2B2_HUMANPlasma membrane calcium-transporting ATPase 2 (EC (PMCA2)(Plasma membrane calcium pump isoform 2) (Plasma membrane calciumATPase isoform 2). 2Show
23ATP2B3AT2B3_HUMANPlasma membrane calcium-transporting ATPase 3 (EC (PMCA3)(Plasma membrane calcium pump isoform 3) (Plasma membrane calciumATPase isoform 3). 1Show
24ATP2B4AT2B4_HUMANPlasma membrane calcium-transporting ATPase 4 (EC (PMCA4)(Plasma membrane calcium pump isoform 4) (Plasma membrane calciumATPase isoform 4) (Matrix-remodeling-associated protein 1). 1Show
25ATF2ATF2_HUMANCyclic AMP-dependent transcription factor ATF-2 (Activatingtranscription factor 2) (cAMP response element-binding protein CRE-BP1) (HB16). 2Show
26SLC4A3B3A3_HUMANAnion exchange protein 3 (Neuronal band 3-like protein) (Solutecarrier family 4 member 3) (Cardiac/brain band 3-like protein)(CAE3/BAE3). 2Show
27BCL2BCL2_HUMANApoptosis regulator Bcl-2. 2Show
28BDKRB2BKRB2_HUMANB2 bradykinin receptor (BK-2 receptor) (B2R). 2Show
29BNC1BNC1_HUMANZinc finger protein basonuclin-1. 1Show
30BTBD14BBTB14_HUMANBTB/POZ domain-containing protein 14B (Nucleus accumbens-1) (NAC-1). 1Show
31BTKBTK_HUMANTyrosine-protein kinase BTK (EC (Bruton tyrosine kinase)(Agammaglobulinaemia tyrosine kinase) (ATK) (B-cell progenitor kinase)(BPK). 1Show
32CD163C163A_HUMANScavenger receptor cysteine-rich type 1 protein M130 precursor(Hemoglobin scavenger receptor) (CD163 antigen) [Contains: SolubleCD163 (sCD163)]. 2Show
33C5AR1C5AR_HUMANC5a anaphylatoxin chemotactic receptor (C5a-R) (C5aR) (CD88 antigen). 5Show
34CANXCALX_HUMANCalnexin precursor (Major histocompatibility complex class I antigen-binding protein p88) (p90) (IP90). 1Show
35CASP9CASP9_HUMANCaspase-9 precursor (EC (CASP-9) (ICE-like apoptoticprotease 6) (ICE-LAP6) (Apoptotic protease Mch-6) (Apoptotic protease-activating factor 3) (APAF-3) [Contains: Caspase-9 subunit p35;Caspase-9 subunit p10]. 2Show
36CASRCASR_HUMANExtracellular calcium-sensing receptor precursor (CaSR) (ParathyroidCell calcium-sensing receptor) (PCaR1). 4Show
37CBLCBL_HUMANE3 ubiquitin-protein ligase CBL (EC 6.3.2.-) (Signal transductionprotein CBL) (Proto-oncogene c-CBL) (Casitas B-lineage lymphoma proto-oncogene) (RING finger protein 55). 4Show
38CREBBPCBP_HUMANCREB-binding protein (EC 2Show
39CD226CD226_HUMANCD226 antigen precursor (DNAX accessory molecule 1) (DNAM-1). 1Show
40CD3GCD3G_HUMANT-cell surface glycoprotein CD3 gamma chain precursor (T-cell receptorT3 gamma chain). 1Show
41CD44CD44_HUMANCD44 antigen precursor (Phagocytic glycoprotein I) (PGP-1) (HUTCH-I)(Extracellular matrix receptor-III) (ECMR-III) (GP90 lymphocytehoming/adhesion receptor) (Hermes antigen) (Hyaluronate receptor)(Heparan sulfate proteoglycan) (Epican) (CDw44). 3Show
42PTPRCCD45_HUMANLeukocyte common antigen precursor (EC (L-CA) (T200) (CD45antigen). 1Show
43CD5CD5_HUMANT-cell surface glycoprotein CD5 precursor (Lymphocyte antigen T1/Leu-1) (CD5 antigen). 8Show
44CDKN1ACDN1A_HUMANCyclin-dependent kinase inhibitor 1 (p21) (CDK-interacting protein 1)(Melanoma differentiation-associated protein 6) (MDA-6). 3Show
45CENTA1CENA1_HUMANCentaurin-alpha-1 (Putative MAPK-activating protein PM25). 6Show
46CFTRCFTR_HUMANCystic fibrosis transmembrane conductance regulator (CFTR) (cAMP-dependent chloride channel) (ATP-binding cassette transporter sub-family C member 7). 6Show
47CNPCN37_HUMAN2',3'-cyclic-nucleotide 3'-phosphodiesterase (EC (CNP)(CNPase). 1Show
48CORO1BCOR1B_HUMANCoronin-1B (Coronin-2). 2Show
49CREMCREM_HUMANcAMP-responsive element modulator (Inducible cAMP early repressor)(ICER). 1Show
50CSPG4CSPG4_HUMANChondroitin sulfate proteoglycan 4 precursor (Chondroitin sulfateproteoglycan NG2) (Melanoma chondroitin sulfate proteoglycan)(Melanoma-associated chondroitin sulfate proteoglycan). 1Show
51GJA1CXA1_HUMANGap junction alpha-1 protein (Connexin-43) (Cx43) (Gap junction 43 kDaheart protein). 4Show
52GJB1CXB1_HUMANGap junction beta-1 protein (Connexin-32) (Cx32) (GAP junction 28 kDaliver protein). 4Show
53PSCD1CYH1_HUMANCytohesin-1 (PH, SEC7 and coiled-coil domain-containing protein 1)(SEC7 homolog B2-1). 5Show
54PSCD2CYH2_HUMANCytohesin-2 (PH, SEC7 and coiled-coil domain-containing protein 2)(ARF nucleotide-binding site opener) (Protein ARNO) (ARF exchangefactor). 4Show
55DAB2DAB2_HUMANDisabled homolog 2 (Differentially-expressed protein 2) (DOC-2). 4Show
56DCXDCX_HUMANNeuronal migration protein doublecortin (Lissencephalin-X) (Lis-X)(Doublin). 6Show
57DDX5DDX5_HUMANProbable ATP-dependent RNA helicase DDX5 (EC 3.6.1.-) (DEAD boxprotein 5) (RNA helicase p68). 2Show
58DGKDDGKD_HUMANDiacylglycerol kinase delta (EC (Diglyceride kinase delta)(DGK-delta) (DAG kinase delta) (130 kDa diacylglycerol kinase). 4Show
59DGKZDGKZ_HUMANDiacylglycerol kinase zeta (EC (Diglyceride kinase zeta)(DGK-zeta) (DAG kinase zeta). 2Show
60DNM1DYN1_HUMANDynamin-1 (EC 1Show
61EEF1A1EF1A1_HUMANElongation factor 1-alpha 1 (EF-1-alpha-1) (Elongation factor 1 A-1)(eEF1A-1) (Elongation factor Tu) (EF-Tu) (Leukocyte receptor clustermember 7). 2Show
62EGFREGFR_HUMANEpidermal growth factor receptor precursor (EC (Receptortyrosine-protein kinase ErbB-1). 3Show
63EP300EP300_HUMANHistone acetyltransferase p300 (EC (E1A-associated proteinp300). 2Show
64EWSR1EWS_HUMANRNA-binding protein EWS (EWS oncogene) (Ewing sarcoma breakpointregion 1 protein). 3Show
65VIL2EZRI_HUMANEzrin (p81) (Cytovillin) (Villin-2). 1Show
66PFKFB2F262_HUMAN6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 2 (6PF-2-K/Fru-2,6-P2ASE heart-type isozyme) (PFK-2/FBPase-2) [Includes: 6-phosphofructo-2-kinase (EC; Fructose-2,6-bisphosphatase(EC]. 2Show
67PFKFB3F263_HUMAN6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 (6PF-2-K/Fru-2,6-P2ASE brain/placenta-type isozyme) (iPFK-2) (Renal carcinomaantigen NY-REN-56) [Includes: 6-phosphofructo-2-kinase (EC;Fructose-2,6-bisphosphatase (EC]. 1Show
68PFKFB4F264_HUMAN6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4 (6PF-2-K/Fru-2,6-P2ASE testis-type isozyme) [Includes: 6-phosphofructo-2-kinase(EC; Fructose-2,6-bisphosphatase (EC]. 1Show
69FGF2FGF2_HUMANHeparin-binding growth factor 2 precursor (HBGF-2) (Basic fibroblastgrowth factor) (BFGF) (Prostatropin). 1Show
70FGAFIBA_HUMANFibrinogen alpha chain precursor [Contains: Fibrinopeptide A]. 4Show
71FSCN1FSCN1_HUMANFascin (Singed-like protein) (55 kDa actin-bundling protein) (p55). 3Show
72FUSFUS_HUMANRNA-binding protein FUS (Oncogene FUS) (Oncogene TLS) (Translocated inliposarcoma protein) (POMp75) (75 kDa DNA-pairing protein). 1Show
73FYNFYN_HUMANProto-oncogene tyrosine-protein kinase Fyn (EC (p59-Fyn)(Protooncogene Syn) (SLK). 1Show
74GABRB1GBRB1_HUMANGamma-aminobutyric acid receptor subunit beta-1 precursor (GABA(A)receptor subunit beta-1). 1Show
75GABRB2GBRB2_HUMANGamma-aminobutyric acid receptor subunit beta-2 precursor (GABA(A)receptor subunit beta-2). 1Show
76GABRG2GBRG2_HUMANGamma-aminobutyric acid receptor subunit gamma-2 precursor (GABA(A)receptor subunit gamma-2). 3Show
77GEMGEM_HUMANGTP-binding protein GEM (GTP-binding mitogen-induced T-cell protein)(RAS-like protein KIR). 1Show
78GFAPGFAP_HUMANGlial fibrillary acidic protein (GFAP). 6Show
79GFPT1GFPT1_HUMANGlucosamine--fructose-6-phosphate aminotransferase [isomerizing] 1(EC (Glutamine:fructose 6 phosphate amidotransferase 1)(Hexosephosphate aminotransferase 1) (D-fructose-6-phosphateamidotransferase 1) (GFAT 1) (GFAT1). 4