Regulatory Network in Protein Phosphorylation
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The kinase complement of the human genome, the kinome, provided a start point for comprehensive investigation of protein phosphorylation. Manning et al. identified 518 protein kinase genes and 106 protein kinase pseudogenes in human (Manning et al., 2002 Science). Most protein kinases contain a conserved catalytic domain belonging to the eukaryotic protein kinase (ePK) superfamily (all other protein kinases are classified as atypical protein kinases, or aPKs). ePKs are classified into 7 major groups, including AGC, CAMK, CK1, CMGC, STE, TK, and TKL, and are subdivided into families, and sometimes subfamilies, based on the sequence of their ePK domains. All 518 human kinases are listed as following, users can clikc into the URL link to investigate the detail information about the kinase and their substrates.

[All kinases] [Kinase families] [Tree view of kinase families]

No.GroupFamilySubfamilyDescriptionKinase members
1AGCPKB Protein kinase B AKT1 AKT2 AKT3
2AGCDMPKROCK Rho Kinase ROCK1 ROCK2
3AGCDMPKGEK Genghis Khan DMPK1 DMPK2 MRCKa MRCKb
4AGCDMPKCRIK Citron Rho-interacting kinase CRIK
5AGCGRKGRK G-protein coupled Receptor Kinase GPRK7 RHOK GPRK6 GPRK5 GPRK4
6AGCGRKBARK Beta Adrenergic Receptor Kinase BARK1 BARK2
7AGCMASTMAST Microtubule Associated Serine/Threonine Kinase MAST1 MAST2 MAST3 MAST4
8AGCMASTMASTL MAST like MASTL
9AGCNDR Nuclear Dbf2-related kinases NDR1 NDR2 LATS1 LATS2
10AGCPKA Protein kinase A PKACa PKACb PKACg
11AGCPDK1 Phosphoinositide-dependent protein kinase PDK1
12AGCPKC Protein kinase C PKCh PKCa PKCb PKCd PKCe PKCg PKCi PKCt PKCz
13AGCPKCAlpha Protein kinase C, alpha PKCa PKCb PKCg
14AGCPKCDelta Protein kinase C, delta PKCd PKCt
15AGCPKCEta Protein kinase C, eta PKCe PKCh
16AGCPKCIota Protein kinase C, iota PKCi PKCz
17AGCPKG Protein kinase G PKG1 PKG2
18AGCPKN Protein kinase N PKN1 PKN2 PKN3
19AGCRSKRSK Ribosomal S6 Kinase RSK1 RSK2 RSK3 RSK4
20AGCRSKp70 p70 subfamily of Ribosomal Specific Kinase p70S6K p70S6Kb
21AGCRSKMSK Mitogen- and Stress-activated protein Kinase MSK1 MSK2
22AGCRSKL RSK-like RSKL1 RSKL2
23AGCRSKR RSK-related SgK494
24AGCSGK Serum and Glucocorticoid Resposive Kinase SGK SGK2 SGK3
25AGCYANK Yet Another Novel Kinase YANK1 YANK2 YANK3
26AtypicalABC1 ABC1 atypical kinases ADCK1 ADCK2 ADCK3 ADCK4 ADCK5
27AtypicalAlphaAlpha Ancient family of atypical kinases AlphaK1 AlphaK2 AlphaK3
28AtypicalAlphaeEF2K Eukaryotic Elongation Factor 2 Kinase eEF2K
29AtypicalAlphaChaK Channel Kinase ChaK1 ChaK2
30AtypicalBCR Breakpoint Cluster Region kinase BCR
31AtypicalBRD Bromodomain containing kinases BRDT BRD2 BRD3 BRD4
32AtypicalFAST  FASTK
33AtypicalG11  G11(STK19)
34AtypicalH11  H11
35AtypicalPDHKPDHK Pyruvate Dehydrogenase Kinase PDHK1 PDHK2 PDHK3 PDHK4 BCKDK
36AtypicalPDHKBCKDK Branched Chain Ketoacid Dehydrogenase Kinase BCKDK
37AtypicalPIKKTRRAP TRansactivation/tRansformation-domain Associated Protein TRRAP
38AtypicalPIKKSMG1  SMG1
39AtypicalPIKKATM Ataxia telangiectasia mutated ATM ATR
40AtypicalPIKKDNAPK DNA Protein Kinase DNAPK
41AtypicalPIKKFRAP FKBP12-rapamycin-associated protein FRAP
42AtypicalRIO  RIOK1 RIOK2 RIOK3
43AtypicalTAF1  TAF1 TAF1L
44AtypicalTIF1 Transcriptional Intermediary Factor TIF1a TIF1b TIF1b
45CAMKCAMK-Unique  VACAMKL STK33
46CAMKCAMK1 CAMK family 1 CaMK1a CaMK1b CaMK1g CaMK1d CaMK4
47CAMKCAMK2 CAMK family 2 CaMK2a CaMK2b CaMK2g CaMK2d
48CAMKCAMKLNIM1  NIM1
49CAMKCAMKLNuaK Novel (Nua) Kinase family NuaK1 NuaK2
50CAMKCAMKLPASK PAS domain Kinase PASK
51CAMKCAMKLQIK Qin Induced Kinase QIK QSK SIK
52CAMKCAMKLSNRK  SNRK
53CAMKCAMKLMELK Maternal Embryonic Leucine zipper Kinase MELK
54CAMKCAMKLAMPK AMP-activated protein kinase AMPKa1 AMPKa2
55CAMKCAMKLCHK1 Checkpoint Kinase 1 CHK1
56CAMKCAMKLCHK2 Checkpoint Kinase 2 CHK2
57CAMKCAMKLHUNK Hormonally Upregulated Neu-associated Kinase HUNK
58CAMKCAMKLLKB  LKB1
59CAMKCAMKLMARK Microtubule Affinity Regulating Kinase MARK1 MARK2 MARK3 MARK4
60CAMKCAMKLBRSK BRain Specific Kinase BRSK1
61CAMKCASK calcium/calmodulin-dependent serine protein kinase CASK
62CAMKDAPK Death Associated Protein Kinase DAPK1 DAPK2 DAPK3 DRAK1 DRAK2
63CAMKDCAMKL Doublecortin and CaMK-Like DCLK1 DCLK2 DCLK3
64CAMKMAPKAPKMAPKAPK MAP Kinase Associated Protein Kinase MAPKAPK2 MAPKAPK3 MAPKAPK5
65CAMKMAPKAPKMNK MAPK iNtegrating or iNteracting Kinase MNK1 MNK2
66CAMKMLCK Myosin Light Chain Kinases smMLCK TTN caMLCK skMLCK Sgk085
67CAMKPHK Phosphorylase Kinase PHKg1 PHKg2
68CAMKPIM  PIM1 PIM2 PIM3
69CAMKPKD Protein Kinase D PKD1 PKD2 PKD3
70CAMKPSK Protein Serine Kinase PSKH1 PSKH2
71CAMKSgK495  SgK495
72CAMKTrbl tribbles Trb1 Trb2 Trb3
73CAMKTrio  Trad Trio SPEG Obscn
74CAMKTSSK Testis Specific Serine Kinase  TSSK1 TSSK2 TSSK3 TSSK4 SSTK
75CK1CK1 Cell Kinase 1 CK1a CK1d CK1e CK1g2 CK1g3 CK1a2 CK1g1
76CK1TTBK Tau Tubulin Kinase TTBK1 TTBK2
77CK1VRK Vaccinia Related Kinase VRK1 VRK2 VRK3
78CMGCCDKCDK Cyclin Dependent Kinase CDK4 CDK5 CDK6 CDK8 CDK9 CDK10 CDK11
79CMGCCDKCDK7 Cyclin Dependent Kinase subfamily 7 CDK7
80CMGCCDKCDC2 Cell Division Control 2 CDC2 CDK2 CDK3
81CMGCCDKCRK7  CHED CRK7
82CMGCCDKPCTAIRE  PCTAIRE1 PCTAIRE2 PCTAIRE3
83CMGCCDKPFTAIRE  PFTAIRE1 PFTAIRE2
84CMGCCDKPITSLRE  PITSLRE
85CMGCCDKL Cyclin Dependent Kinase Like CDKL1 CDKL2 CDKL3 CDKL4 CDKL5
86CMGCCK2 Casein kinase II CK2a1 CK2a2 CK2al-rs
87CMGCCLK CDC-Like Kinase, involved in splicing CLK1 CLK2 CLK3 CLK4
88CMGCDYRKPRP4  PRP4
89CMGCDYRKHIPK Homeodomain Interacting Protein Kinases HIPK1 HIPK2 HIPK3 HIPK4
90CMGCDYRKDYRK Dual-specificity Tyrosine Regulated Kinase DYRK1A DYRK1B DYRK2 DYRK3 DYRK4
91CMGCGSK Gycogen Synthase 3 Kinase GSK3A GSK3B
92CMGCMAPKMAPK Mitogen Activated Protein Kinase Erk1(MAPK3) Erk2(MAPK1) Erk3(MAPK6) Erk4(MAPK4) Erk5(MAPK7) Erk7(MAPK15) JNK1(MAPK8) JNK2(MAPK9) JNK3(MAPK10) NLK p38a(MAPK14) p38b(MAPK11) p38g(MAPK12) p38d(MAPK13)
93CMGCMAPKJNK JNK subfamily of MAPK JNK1(MAPK8) JNK2(MAPK9) JNK3(MAPK10)
94CMGCMAPKp38 p38 subfamily of MAPK p38a(MAPK14) p38b(MAPK11) p38g(MAPK12) p38d(MAPK13)
95CMGCMAPKERK Extracellular signal-Regulated protein Kinase Erk1(MAPK3) Erk2(MAPK1) Erk3(MAPK6) Erk4(MAPK4) Erk5(MAPK7) Erk7(MAPK15)
96CMGCMAPKnmo nemo NLK
97CMGCRCK  MAK MOK ICK
98CMGCSRPK SR Protein Kinase; phosphorylates SR splicing factors MSSK1 SRPK1 SRPK2
99OtherAURAur Aurora Kinase AurA AurB AurC
100OtherAURAurB Aurora Kinase B AurB
101OtherAURAurA Aurora Kinase B AurA
102OtherBUB  BUB1 BUBR1
103OtherBud32  PRPK
104OtherCAMKKMeta Metazoan-specific family of CAMK (Calcium/Calmodulin Regulated Kinase) Kinase CaMKK1 CaMKK2
105OtherCDC7 Cell Division Control 7 CDC7
106OtherHaspin  Haspin
107OtherIKK I kappa Kinase IKKa IKKb IKKe TBK1
108OtherIRE Inositol REquiring  IRE1 IRE2
109OtherMOS  MOS
110OtherKIS Kinase interacting with stathmin KIS
111OtherNAK Numb-Associated Kinase MPSK1 GAK BIKE AAK1
112OtherNEK Mitotic Kinase family, also known as NRK (NimA-Related Kinase, based on Aspergillus NimA) NEK1 NEK2 NEK3 NEK4 NEK5 NEK6 NEK7 NEK8 NEK9 NEK10 NEK11
113OtherNKF1 New Kinase Family 1 SgK110 SgK069 SBK
114OtherNKF2 New Kinase Family 2 PINK1
115OtherNKF3 New Kinase Family 3 SgK269 SgK223
116OtherNKF4 New Kinase Family 4 CLIK1 CLIK1L
117OtherNKF5 New Kinase Family 5 SgK307 SgK424
118OtherNRBP Nuclear Receptor Binding Protein NRBP1 NRBP2
119OtherOther-Unique  RNAseL SgK396 SgK196
120OtherPEKGCN2 General Control Non-derepressible GCN2
121OtherPEKPKR Interferon-induced, double-stranded RNA-activated protein kinase PKR
122OtherPEKPEK Pancreatic eIF-2alpha Kinase  PEK
123OtherPEKHRI Heme-Regulated Inhibitor kinase  HRI
124OtherPLK Polo Like Kinases PLK1 PLK2 PLK3 PLK4
125OtherSCY1  SCYL1 SCYL2 SCYL3
126OtherSgK071  SgK071
127OtherSgK493  SgK493
128OtherSgK496  SgK496
129OtherSlob Named after the first member, Drosophila SLOw Borders Slob
130OtherTBCK TBC domain-containing Kinase TBCK
131OtherTLK Tousled-Like Kinase TLK1 TLK2
132OtherTOPK T-cell Originated Kinase, also known as PBK (PDZ domain-binding kinase) PBK
133OtherTTK  TTK
134OtherULKULK Unc-51 Like Kinase ULK1 ULK2 ULK3 ULK4
135OtherULKFused  Fused
136OtherVPS15  PIK3R4
137OtherWEE Homologs of yeast Wee1; cell cycle kinase Wee1 Wee1B MYT1
138OtherWNK With No Lysine kinases. Missing the canonical catalytic lysine, instead using a nearby lysine for catalysis Wnk1 Wnk2 Wnk3 Wnk4
139OtherCDPK  CDPK
140RGCRGC Receptor Guanylate Cyclases ANPa ANPb CYGD CYGF HSER
141STESTE-Unique  COT NIK
142STESTE11MAP3K MAP3K (MAP kinase kinase kinase) genes, homologous to yeast Ste 11 MAP3K1 MAP3K2 MAP3K3 MAP3K4 MAP3K5 MAP3K6 MAP3K7 MAP3K8
143STESTE20PAK p21-Activated protein Kinase PAK1 PAK2 PAK3 PAK4 PAK5 PAK6
144STESTE20PAKB Class B p21-Activated protein Kinase PAK4 PAK5 PAK6
145STESTE20PAKA Class A p21-Activated protein Kinase PAK1 PAK2 PAK3
146STESTE20SLK Ste20-Like Kinase  LOK SLK
147STESTE20STLK Serine Threonine Like Kinase STLK5 STLK6 STLK6-rs
148STESTE20TAO Thousand and One Kinase, whose sequence was 1001 AA long. Also known as the SULU family TAO1 TAO3 TAO3
149STESTE20YSK Yeast SPS1/STE20-like kinase YSK1 MST3 MST4
150STESTE20KHS Kinase Homologous to STE20 KHS1 KHS2 GCK HPK1
151STESTE20FRAY  STLK3 OSR1
152STESTE20MSN misshapen HGK TNIK NRK MINK
153STESTE20MST Mammalian STE20-like kinase MST1 MST2
154STESTE20NinaC  MYO3A MYO3B
155STESTE7MAP2K MAP2K (MAP kinase kinase) genes, homologous to yeast Ste 7 MAP2K1 MAP2K2 MAP2K3 MAP2K4 MAP2K5 MAP2K6 MAP2K7
156TKAbl Abelson murine leukemia homolog ABL1(Abl) ABL2(ARG)
157TKAck Activated Cdc42-associated tyrosine kinase ACK TNK1
158TKALK Anaplastic Lymphoma Kinase ALK LTK
159TKAxl  AXL MER TYRO3
160TKCCK4 Colon Carcinoma Kinase 4 CCK4
161TKCsk C-SRC kinase CSK CTK
162TKDDR Discoidin Domain Receptor kinase DDR1 DDR2
163TKEGFR Epidermal Growth Factor Receptor EGFR ErbB2 ErbB3 ErbB4
164TKEph Ephrin receptors EphA1 EphA2 EphA3 EphA4 EphA5 EphA6 EphA7 EphA8 EphA10 EphB1 EphB2 EphB3 EphB4 EphB5 EphB6
165TKFAK Focal Adhesion Kinase FAK PYK2
166TKFerFer Proto-oncogene tyrosine-protein kinase FER FER
167TKFerFes Proto-oncogene tyrosine-protein kinase Fes/Fps FES
168TKFGFR Fibroblast Growth Factor Receptor FGFR1 FGFR2 FGFR3 FGFR4
169TKInsR Insulin Receptor and associated Kinases INSR IRR
170TKInsRIGF1R Insulin-like growth factor I receptor IGF1R
171TKJAKJakA First (active) kinase domain of the dual-domain Janus Kinases JAK1 JAK2 JAK3
172TKTYKTYK2 Non-receptor tyrosine-protein kinase TYK2
173TKLmr Lemur Kinase LMR1 LMR2 LMR3
174TKMetMet Met proto-oncogene tyrosine kinase MET RON
175TKMusk Muscle-Specific Kinase MUSK
176TKPDGFRPDGFR Platelet-derived growth factor PDGFRa PDGFRb
177TKPDGFRFms Platelet-derived growth factor, FMS FMS
178TKPDGFRFLT3 Fms-Like Tyrosine kinase FLT3
179TKPDGFRKit Platelet-derived growth factor KIT
180TKRet Proto-oncogene tyrosine-protein kinase receptor ret RET
181TKRor Regeneron Orphan Receptors ROR1 ROR2
182TKRyk Receptor Tyrosine Kinase RYK
183TKSev Named after Drosophila sevenless, a receptor tyrosine kinase involved in eye cell fate determination ROS
184TKSrcSRM Proto-oncogene tyrosine-protein kinase SRM SRM
185TKSrcBLK Proto-oncogene tyrosine-protein kinase BLK BLK
186TKSrcBrk Proto-oncogene tyrosine-protein kinase BRK BRK
187TKSrcFgr Proto-oncogene tyrosine-protein kinase FGR FGR
188TKSrcFyn Proto-oncogene tyrosine-protein kinase FYN FYN
189TKSrcHCK Proto-oncogene tyrosine-protein kinase HCK HCK
190TKSrcLck Proto-oncogene tyrosine-protein kinase Lck LCK
191TKSrcLYN Tyrosine-protein kinase LYN LYN
192TKSrcSrc Proto-oncogene tyrosine-protein kinase Src SRC
193TKSrcYES Proto-oncogene tyrosine-protein kinase YES YES
194TKSrcFrk Fyn-related kinase FRK
195TKSykSYK Spleen tyrosine kinase SYK
196TKSykZAP70 70 kDa zeta-associated protein, Syk-related tyrosine kinase ZAP70
197TKTec Tec protein tyrosine kinase family TXK TEC ITK BMX BTK
198TKTecBTK Bruton tyrosine kinase BTK
199TKTecITK IL2-inducible T-cell kinase ITK
200TKTecTXK Tyrosine-protein kinase TXK TXK TEC
201TKTie Tunica interna endothelial cell kinase TIE1 TIE2
202TKTK-Unique  SuRTK106
203TKTrk Neurotrophin receptor tyrosine kinases TRKA TRKB TRKC
204TKVEGFR Vascular Endothelial Growth Factor Receptors FLT1 FLT4 FLT3 KDR
205TKLIRAK IL1 Receptor Associated Kinase IRAK1 IRAK2 IRAK3 IRAK4
206TKLLISKTESK TEstis Specific Kinase TESK1 TESK2
207TKLLISKLIMK LIM domain containing kinase LIMK1 LIMK2
208TKLLRRK Leucine Rich Repeat Kinase LRRK1 LRRK2
209TKLMLKMLK Mixed Lineage Kinase MLK1 MLK2 MLK3 MLK4
210TKLMLKLZK Leucine zipper-bearing kinase  LZK DLK
211TKLMLKZAK Sterile alpha motif and leucine zipper containing kinase AZK ZAK
212TKLMLKTAK1 Transforming growth factor-]-activated kinase 1 TAK1
213TKLMLKHH498  HH498
214TKLMLKILK Integrin Linked Kinase ILK
215TKLRAFRAF RAF proto-oncogene serine/threonine-protein kinase RAF1 ARAF BRAF
216TKLRAFKSR Kinase Suppressor of Ras KSR1 KSR2
217TKLRIPK Receptor Interacting Protein Kinases RIPK1 RIPK2 RIPK3 SgK288 ANKRD3
218TKLSTKRType1 Serine/Threonine Kinase Receptors; receptors for activin and TGFb ligands. Type 1 TGFbR1 ALK7 ALK1 ALK2 ALK4 BMPR1A BMPR1B
219TKLSTKRType2 Serine/Threonine Kinase Receptors; receptors for activin and TGFb ligands. Type 2 TGFbR2 BMPR2 MISR2 ACTR2 ACTR2B
220TKLSTKRTGFbR Serine/Threonine Kinase Receptors; receptors for TGFb ligands TGFbR1 TGFbR2
221TKLTKL-Unique  MLKL