Regulatory Network in Protein Phosphorylation
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Substrate: YWHAB

Description: 14-3-3 protein beta/alpha (Protein kinase C inhibitor protein 1)(KCIP-1) (Protein 1054).

Ensembl ID: ENSG00000166913

UniprotKB/SwissProt: 1433B_HUMAN (P31946)

Function: Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathway. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner.

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization: Cytoplasm. Melanosome. Note=Identified by mass spectrometry in melanosome fractions from stage I to stage IV.
PDB:2BQ0
Protein Domain and Phosphorylation Sites:

The phosphorylated sites of YWHAB

No.SubstrateUniProtKB IDPositionPhosphoPeptideSolvent AccessibilityCatalytic kinaseSourceComputational Annotation of Catalytic KinaseInteracting PartnersExpression Analysis
1YWHAB1433B_HUMANS60GARRS S WRVIS 19.65%SDK1 Phospho.ELM 7.0 ViewAnalyzing
2YWHAB1433B_HUMANS60GARRS S WRVIS 19.65%PKCd(PKC delta) Phospho.ELM 7.0 ViewAnalyzing
3YWHAB1433B_HUMANS60GARRS S WRVIS 19.65% HPRD:03184(in vivo)View   
4YWHAB1433B_HUMANS132YFRYL S EVASG 22.53%PKCz(PKC zeta) Phospho.ELM 7.0 ViewAnalyzing
5YWHAB1433B_HUMANS132YFRYL S EVASG 22.53%PKCz HPRD:03184(in vitro;in vivo)  ViewAnalyzing
6YWHAB1433B_HUMANT143DNKQT T VSNSQ 21.31%PKCz HPRD:03184(in vitro;in vivo)  ViewAnalyzing
7YWHAB1433B_HUMANT143DNKQT T VSNSQ 21.31%PKCz(PKC zeta) Phospho.ELM 7.0 ViewAnalyzing
8YWHAB1433B_HUMANS186YEILN S PEKAC 30.87% HPRD:03184(in vivo)View   
9YWHAB1433B_HUMANS186YEILN S PEKAC 30.87%JNK1(MAPK8) Phospho.ELM 7.0 ViewAnalyzing
10YWHAB1433B_HUMANS186YEILN S PEKAC 30.87% Swiss-Prot 55.0 (Similarity)View