Regulatory Network in Protein Phosphorylation
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Substrate: YWHAE

Description: 14-3-3 protein epsilon (14-3-3E).

Ensembl ID: ENSG00000108953

UniprotKB/SwissProt: 1433E_HUMAN (P62258)

Function: Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathway. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner.

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization: Cytoplasm (By similarity). Melanosome. Note=Identified by mass spectrometry in melanosome fractions from stage I to stage IV.
PDB:2BR9
Protein Domain and Phosphorylation Sites:

The phosphorylated sites of YWHAE

No.SubstrateUniProtKB IDPositionPhosphoPeptideSolvent AccessibilityCatalytic kinaseSourceComputational Annotation of Catalytic KinaseInteracting PartnersExpression Analysis
1YWHAE1433E_HUMANS210ELDTL S EESYK 41.22% Swiss-Prot 55.0 (Similarity)View