Regulatory Network in Protein Phosphorylation
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Substrate: BAD

Description: Bcl2 antagonist of cell death (BAD) (Bcl-2-binding component 6) (Bcl-XL/Bcl-2-associated death promoter) (Bcl-2-like 8 protein).

Synonyms: BBC6, BCL2L8

Ensembl ID: ENSG00000002330

UniprotKB/SwissProt: BAD_HUMAN (Q92934)

Function: Promotes cell death. Successfully competes for the binding to Bcl-X(L), Bcl-2 and Bcl-W, thereby affecting the level of heterodimerization of these proteins with BAX. Can reverse the death repressor activity of Bcl-X(L), but not that of Bcl-2 (By similarity). Appears to act as a link between growth factor receptor signaling and the apoptotic pathways.

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization: Mitochondrion outer membrane. Cytoplasm. Note=Upon phosphorylation, locates to the cytoplasm.
PDB:1G5J
Protein Domain and Phosphorylation Sites:

The phosphorylated sites of BAD

No.SubstrateUniProtKB IDPositionPhosphoPeptideSolvent AccessibilityCatalytic kinaseSourceComputational Annotation of Catalytic KinaseInteracting PartnersExpression Analysis
1BADBAD_HUMANS75RSRHS S YPAGT 29.07%RSK1 Phospho.ELM 7.0  ViewAnalyzing
2BADBAD_HUMANS75RSRHS S YPAGT 29.07%RSK1 HPRD:04409(in vitro;in vivo)  ViewAnalyzing
3BADBAD_HUMANS75RSRHS S YPAGT 29.07%PIM2 HPRD:04409(in vitro;in vivo)  ViewAnalyzing
4BADBAD_HUMANS75RSRHS S YPAGT 29.07%PIM3 HPRD:04409(in vitro;in vivo)  ViewAnalyzing
5BADBAD_HUMANS75RSRHS S YPAGT 29.07%PKA_group Phospho.ELM 7.0 ViewAnalyzing
6BADBAD_HUMANS75RSRHS S YPAGT 29.07%p38a(MAPK14) Phospho.ELM 7.0 ViewAnalyzing
7BADBAD_HUMANS75RSRHS S YPAGT 29.07%PAK5 HPRD:04409(in vitro;in vivo)  ViewAnalyzing
8BADBAD_HUMANS75RSRHS S YPAGT 29.07%AKT1 HPRD:04409(in vitro;in vivo)  ViewAnalyzing
9BADBAD_HUMANS75RSRHS S YPAGT 29.07%AKT1 HPRD:04409(in vitro;in vivo)  ViewAnalyzing
10BADBAD_HUMANS75RSRHS S YPAGT 29.07%PKA_group Swiss-Prot 55.0 (Similarity) ViewAnalyzing
11BADBAD_HUMANS75RSRHS S YPAGT 29.07%AKT_group Swiss-Prot 55.0 (Similarity) ViewAnalyzing
12BADBAD_HUMANS75RSRHS S YPAGT 29.07%RSK3 HPRD:04409(in vitro;in vivo)  ViewAnalyzing
13BADBAD_HUMANS75RSRHS S YPAGT 29.07%PIM1 HPRD:04409(in vitro;in vivo)  ViewAnalyzing
14BADBAD_HUMANS99RGRSR S APPNL 46.50%AKT_group Swiss-Prot 55.0 (Similarity) ViewAnalyzing
15BADBAD_HUMANS99RGRSR S APPNL 46.50%PIM1 HPRD:04409(in vitro;in vivo)  ViewAnalyzing
16BADBAD_HUMANS99RGRSR S APPNL 46.50%PIM3 HPRD:04409(in vitro;in vivo)  ViewAnalyzing
17BADBAD_HUMANS99RGRSR S APPNL 46.50%AKT1 HPRD:04409(in vitro;in vivo)  ViewAnalyzing
18BADBAD_HUMANS99RGRSR S APPNL 46.50%PIM2 HPRD:04409(in vitro;in vivo)  ViewAnalyzing
19BADBAD_HUMANS99RGRSR S APPNL 46.50%AKT_group Phospho.ELM 7.0 ViewAnalyzing
20BADBAD_HUMANS99RGRSR S APPNL 46.50%PKA_group Swiss-Prot 55.0 (Similarity) ViewAnalyzing
21BADBAD_HUMANS118ELRRM S DEFVD 31.98%AKT1 HPRD:04409(in vitro;in vivo)  ViewAnalyzing
22BADBAD_HUMANS118ELRRM S DEFVD 31.98%AKT1 HPRD:04409(in vitro;in vivo)  ViewAnalyzing
23BADBAD_HUMANS118ELRRM S DEFVD 31.98%RSK3 HPRD:04409(in vitro;in vivo)  ViewAnalyzing
24BADBAD_HUMANS118ELRRM S DEFVD 31.98%RSK1 Phospho.ELM 7.0  ViewAnalyzing
25BADBAD_HUMANS118ELRRM S DEFVD 31.98%PIM1 HPRD:04409(in vitro;in vivo)  ViewAnalyzing
26BADBAD_HUMANS118ELRRM S DEFVD 31.98%PIM2 HPRD:04409(in vitro;in vivo)  ViewAnalyzing
27BADBAD_HUMANS118ELRRM S DEFVD 31.98%PIM3 HPRD:04409(in vitro;in vivo)  ViewAnalyzing
28BADBAD_HUMANS118ELRRM S DEFVD 31.98%PKA_group Swiss-Prot 55.0 (Similarity) ViewAnalyzing
29BADBAD_HUMANS118ELRRM S DEFVD 31.98%AKT_group Swiss-Prot 55.0 (Similarity) ViewAnalyzing
30BADBAD_HUMANS118ELRRM S DEFVD 31.98%RSK1 HPRD:04409(in vitro;in vivo)  ViewAnalyzing
31BADBAD_HUMANS118ELRRM S DEFVD 31.98%PKACa HPRD:04409(in vitro;in vivo)  ViewAnalyzing
32BADBAD_HUMANS134LPRPK S AGTAT 34.31% Swiss-Prot 55.0 (Similarity)View   
33BADBAD_HUMANS134LPRPK S AGTAT 34.31% HPRD:04409(in vitro;in vivo)View   
34BADBAD_HUMANS153TRVFQ S WWDRN 20.76%PKACa HPRD:04409(in vitro;in vivo)  ViewAnalyzing
35BADBAD_HUMANS153TRVFQ S WWDRN 20.76%MSK1 HPRD:04409(in vitro)  ViewAnalyzing
36BADBAD_HUMANS153TRVFQ S WWDRN 20.76%RSK3 HPRD:04409(in vitro;in vivo)  ViewAnalyzing