|Description: Baculoviral IAP repeat-containing protein 4 (EC 6.3.2.-) (E3ubiquitin-protein ligase XIAP) (Inhibitor of apoptosis protein 3) (X-linked inhibitor of apoptosis protein) (X-linked IAP) (IAP-likeprotein) (HILP).|
Synonyms: API3, IAP3, XIAP
Ensembl ID: ENSG00000101966
UniprotKB/SwissProt: BIRC4_HUMAN (P98170)
Function: Apoptotic suppressor. Has E3 ubiquitin-protein ligase activity. Mediates the proteasomal degradation of target proteins, such as caspase-3, SMAC or AIFM1. Inhibitor of caspase-3, -7 and -9. Mediates activation of MAP3K7/TAK1, leading to the activation of NF-kappa-B.
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Cytoplasm.