Regulatory Network in Protein Phosphorylation
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Substrate: BIRC4

Description: Baculoviral IAP repeat-containing protein 4 (EC 6.3.2.-) (E3ubiquitin-protein ligase XIAP) (Inhibitor of apoptosis protein 3) (X-linked inhibitor of apoptosis protein) (X-linked IAP) (IAP-likeprotein) (HILP).

Synonyms: API3, IAP3, XIAP

Ensembl ID: ENSG00000101966

UniprotKB/SwissProt: BIRC4_HUMAN (P98170)

Function: Apoptotic suppressor. Has E3 ubiquitin-protein ligase activity. Mediates the proteasomal degradation of target proteins, such as caspase-3, SMAC or AIFM1. Inhibitor of caspase-3, -7 and -9. Mediates activation of MAP3K7/TAK1, leading to the activation of NF-kappa-B.

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization: Cytoplasm.
PDB:1C9Q
Protein Domain and Phosphorylation Sites:

The phosphorylated sites of BIRC4

No.SubstrateUniProtKB IDPositionPhosphoPeptideSolvent AccessibilityCatalytic kinaseSourceComputational Annotation of Catalytic KinaseInteracting PartnersExpression Analysis
1BIRC4BIRC4_HUMANS87RHRKV S PNCRF 17.27%AKT_group Swiss-Prot 55.0  ViewAnalyzing
2BIRC4BIRC4_HUMANS87RHRKV S PNCRF 17.27%AKT2 HPRD:02094(in vitro;in vivo)  ViewAnalyzing
3BIRC4BIRC4_HUMANS87RHRKV S PNCRF 17.27%Akt2(PKB beta) Phospho.ELM 7.0 ViewAnalyzing
4BIRC4BIRC4_HUMANS87RHRKV S PNCRF 17.27%AKT_group Phospho.ELM 7.0 ViewAnalyzing
5BIRC4BIRC4_HUMANS87RHRKV S PNCRF 17.27%AKT1 HPRD:02094(in vitro;in vivo)  ViewAnalyzing