Regulatory Network in Protein Phosphorylation
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Substrate: BRAF

Description: B-Raf proto-oncogene serine/threonine-protein kinase (EC 2.7.11.1)(p94) (v-Raf murine sarcoma viral oncogene homolog B1).

Synonyms: BRAF1, RAFB1

Ensembl ID: ENSG00000157764

UniprotKB/SwissProt: BRAF1_HUMAN (P15056)

Function: Involved in the transduction of mitogenic signals from the cell membrane to the nucleus. May play a role in the postsynaptic responses of hippocampal neuron.

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization: Cytoplasm.
PDB:1UWH
Protein Domain and Phosphorylation Sites:

The phosphorylated sites of BRAF

No.SubstrateUniProtKB IDPositionPhosphoPeptideSolvent AccessibilityCatalytic kinaseSourceComputational Annotation of Catalytic KinaseInteracting PartnersExpression Analysis
1BRAFBRAF1_HUMANS151RSNPK S PQKPI 33.54% Swiss-Prot 55.0 View   
2BRAFBRAF1_HUMANS151RSNPK S PQKPI 33.54% Phospho.ELM 7.0View   
3BRAFBRAF1_HUMANS365RDRSS S APNVH 49.33%AKT1 HPRD:01264(in vitro;in vivo)  ViewAnalyzing
4BRAFBRAF1_HUMANS365RDRSS S APNVH 49.33%AKT_group Phospho.ELM 7.0 ViewAnalyzing
5BRAFBRAF1_HUMANS365RDRSS S APNVH 49.33%SGK_group Phospho.ELM 7.0 ViewAnalyzing
6BRAFBRAF1_HUMANS365RDRSS S APNVH 49.33%SGK1 HPRD:01264(in vitro;in vivo)  ViewAnalyzing
7BRAFBRAF1_HUMANS365RDRSS S APNVH 49.33% Swiss-Prot 55.0 View   
8BRAFBRAF1_HUMANT373NVHIN T IEPVN 26.56%autocatalysis Swiss-Prot 55.0  ViewAnalyzing
9BRAFBRAF1_HUMANS399STTGL S ATPPA 31.29% Phospho.ELM 7.0View   
10BRAFBRAF1_HUMANT401TGLSA T PPASL 26.82% Swiss-Prot 55.0 View   
11BRAFBRAF1_HUMANT401TGLSA T PPASL 26.82% Phospho.ELM 7.0View   
12BRAFBRAF1_HUMANT401TGLSA T PPASL 26.82% HPRD:01264(in vivo)View   
13BRAFBRAF1_HUMANS419KALQK S PGPQR 23.33% Swiss-Prot 55.0 View   
14BRAFBRAF1_HUMANS419KALQK S PGPQR 23.33% Phospho.ELM 7.0View   
15BRAFBRAF1_HUMANS429RERKS S SSSED 36.96%AKT1 HPRD:01264(in vitro;in vivo)  ViewAnalyzing
16BRAFBRAF1_HUMANS429RERKS S SSSED 36.96%PKA_group Phospho.ELM 7.0 ViewAnalyzing
17BRAFBRAF1_HUMANS429RERKS S SSSED 36.96%AKT_group Phospho.ELM 7.0 ViewAnalyzing
18BRAFBRAF1_HUMANS430ERKSS S SSEDR 45.00%PKACa HPRD:01264(in vitro;in vivo)  ViewAnalyzing
19BRAFBRAF1_HUMANT440RNRMK T LGRRD 25.71% Phospho.ELM 7.0View   
20BRAFBRAF1_HUMANT440RNRMK T LGRRD 25.71% HPRD:01264(in vivo)View   
21BRAFBRAF1_HUMANS446LGRRD S SDDWE 33.58% HPRD:01264(in vitro)View   
22BRAFBRAF1_HUMANS446LGRRD S SDDWE 33.58%PAK1 Phospho.ELM 7.0  ViewAnalyzing
23BRAFBRAF1_HUMANS446LGRRD S SDDWE 33.58% Swiss-Prot 55.0 View   
24BRAFBRAF1_HUMANS579HRDLK S NNIFL 42.26% Phospho.ELM 7.0View   
25BRAFBRAF1_HUMANT599DFGLA T VKSRW 33.24% Phospho.ELM 7.0View   
26BRAFBRAF1_HUMANT599DFGLA T VKSRW 33.24% HPRD:01264(in vitro;in vivo)View   
27BRAFBRAF1_HUMANS602LATVK S RWSGS 34.35% HPRD:01264(in vitro;in vivo)View   
28BRAFBRAF1_HUMANS602LATVK S RWSGS 34.35% Phospho.ELM 7.0View   
29BRAFBRAF1_HUMANS727PKIHR S ASEPS 23.22% Phospho.ELM 7.0View   
30BRAFBRAF1_HUMANS729IHRSA S EPSLN 51.81% Phospho.ELM 7.0View   
31BRAFBRAF1_HUMANS729IHRSA S EPSLN 51.81% Swiss-Prot 55.0 View   
32BRAFBRAF1_HUMANS729IHRSA S EPSLN 51.81% HPRD:01264(in vivo)View   
33BRAFBRAF1_HUMANS750LYACA S PKTPI 27.15% Phospho.ELM 7.0View   
34BRAFBRAF1_HUMANS750LYACA S PKTPI 27.15% Swiss-Prot 55.0 View