|Description: Girdin (Girders of actin filament) (Coiled-coil domain-containingprotein 88A) (Akt phosphorylation enhancer) (APE) (Hook-relatedprotein 1) (HkRP1) (G alpha-interacting vesicle-associated protein)(GIV).|
Synonyms: APE, GRDN, KIAA1212
Ensembl ID: ENSG00000115355
UniprotKB/SwissProt: GRDN_HUMAN (Q3V6T2)
Function: Enhances phosphoinositide 3-kinase (PI3K)-dependent phosphorylation and kinase activity of AKT1/PKB, but does not possess kinase activity itself. Phosphorylation of AKT1/PKB thereby induces the phosphorylation of downstream effectors GSK3 and FOXO1/FKHR, and regulates DNA replication and cell proliferation (By similarity). Essential for the integrity of the actin cytoskeleton and for cell migration. Required for formation of actin stress fibers and lamellipodia. May be involved in membrane sorting in the early endosome.
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Membrane. Cell membrane. Cytoplasm, cytosol. Cytoplasmic vesicle. Cell projection, lamellipodium. Note=Localizes to the cell membrane through interaction with phosphoinositides.