Regulatory Network in Protein Phosphorylation
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Substrate: CCDC88A

Description: Girdin (Girders of actin filament) (Coiled-coil domain-containingprotein 88A) (Akt phosphorylation enhancer) (APE) (Hook-relatedprotein 1) (HkRP1) (G alpha-interacting vesicle-associated protein)(GIV).

Synonyms: APE, GRDN, KIAA1212

Ensembl ID: ENSG00000115355

UniprotKB/SwissProt: GRDN_HUMAN (Q3V6T2)

Function: Enhances phosphoinositide 3-kinase (PI3K)-dependent phosphorylation and kinase activity of AKT1/PKB, but does not possess kinase activity itself. Phosphorylation of AKT1/PKB thereby induces the phosphorylation of downstream effectors GSK3 and FOXO1/FKHR, and regulates DNA replication and cell proliferation (By similarity). Essential for the integrity of the actin cytoskeleton and for cell migration. Required for formation of actin stress fibers and lamellipodia. May be involved in membrane sorting in the early endosome.

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization: Membrane. Cell membrane. Cytoplasm, cytosol. Cytoplasmic vesicle. Cell projection, lamellipodium. Note=Localizes to the cell membrane through interaction with phosphoinositides.
Protein Domain and Phosphorylation Sites:

The phosphorylated sites of CCDC88A

No.SubstrateUniProtKB IDPositionPhosphoPeptideSolvent AccessibilityCatalytic kinaseSourceComputational Annotation of Catalytic KinaseInteracting PartnersExpression Analysis
1CCDC88AGRDN_HUMANS1387KFYDP S PPRRR 44.64% Swiss-Prot 55.0 View   
2CCDC88AGRDN_HUMANS1417RERQK S LTLTP 20.46%AKT1(PKB) Swiss-Prot 55.0  ViewAnalyzing
3CCDC88AGRDN_HUMANT1559VNNKD T TSFED 26.42% Swiss-Prot 55.0 (Similarity)View   
4CCDC88AGRDN_HUMANT1560NNKDT T SFEDI 41.36% Swiss-Prot 55.0 (Similarity)View   
5CCDC88AGRDN_HUMANS1561NKDTT S FEDIS 28.82% Swiss-Prot 55.0 (Similarity)View   
6CCDC88AGRDN_HUMANS1675KIKTG S PGSEV 31.18% Swiss-Prot 55.0 (Similarity)View   
7CCDC88AGRDN_HUMANS1702QIKSS S QENLL 48.91% Swiss-Prot 55.0 (Similarity)View