|Description: Cyclin-dependent kinase inhibitor 1B (Cyclin-dependent kinaseinhibitor p27) (p27Kip1).|
Ensembl ID: ENSG00000111276
UniprotKB/SwissProt: CDN1B_HUMAN (P46527)
Function: Involved in G1 arrest. May mediate TGF beta-induced G1 arrest. Binds to and inhibits complexes formed by cyclin E-CDK2, cyclin A-CDK2, and cyclin D1-CDK4. Interaction with nucleoporin NUP50 is required for nuclear import and for degradation of phosphorylated p27Kip1 after nuclear import (By similarity).
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Nucleus (By similarity). Cytoplasm (By similarity). Note=Nuclear and cytoplasmic in quiescent cells. Upon cell cycle progression, mostly cytoplasmic (By similarity).