Regulatory Network in Protein Phosphorylation
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Substrate: CREB1

Description: cAMP response element-binding protein (CREB).

Ensembl ID: ENSG00000118260

UniprotKB/SwissProt: CREB1_HUMAN (P16220)

Function: This protein binds the cAMP response element (CRE), a sequence present in many viral and cellular promoters. CREB stimulates transcription on binding to the CRE. Transciption activation is enhanced by the TORC coactivators which act independently of Ser-133 phosphorylation. Implicated in synchronization of circadian rhythmicity.

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization: Nucleus.
Protein Domain and Phosphorylation Sites:

The phosphorylated sites of CREB1

No.SubstrateUniProtKB IDPositionPhosphoPeptideSolvent AccessibilityCatalytic kinaseSourceComputational Annotation of Catalytic KinaseInteracting PartnersExpression Analysis
1CREB1CREB1_HUMANS111AESED S QESVD 31.62% Swiss-Prot 55.0 View   
2CREB1CREB1_HUMANS111AESED S QESVD 31.62%ATM Phospho.ELM 7.0  ViewAnalyzing
3CREB1CREB1_HUMANT119SVDSV T DSQKR 33.61% Swiss-Prot 55.0 View   
4CREB1CREB1_HUMANS121DSVTD S QKRRE 28.38%ATM Phospho.ELM 7.0  ViewAnalyzing
5CREB1CREB1_HUMANS121DSVTD S QKRRE 28.38%ATR Phospho.ELM 7.0  ViewAnalyzing
6CREB1CREB1_HUMANS129RREIL S RRPSY 31.72%GSK3B HPRD:00442(in vivo)  ViewAnalyzing
7CREB1CREB1_HUMANS129RREIL S RRPSY 31.72%GSK_group Phospho.ELM 7.0 ViewAnalyzing
8CREB1CREB1_HUMANS133LSRRP S YRKIL 35.44%RSK_group Phospho.ELM 7.0 ViewAnalyzing
9CREB1CREB1_HUMANS133LSRRP S YRKIL 35.44%SGK_group Phospho.ELM 7.0 ViewAnalyzing
10CREB1CREB1_HUMANS133LSRRP S YRKIL 35.44%DYRK Phospho.ELM 7.0 ViewAnalyzing
11CREB1CREB1_HUMANS133LSRRP S YRKIL 35.44%RSK3 HPRD:00442(in vitro)  ViewAnalyzing
12CREB1CREB1_HUMANS133LSRRP S YRKIL 35.44% HPRD:00442(in vitro)View   
13CREB1CREB1_HUMANS133LSRRP S YRKIL 35.44% HPRD:00442(in vitro)View   
14CREB1CREB1_HUMANS133LSRRP S YRKIL 35.44%CaMK2_group Phospho.ELM 7.0 ViewAnalyzing
15CREB1CREB1_HUMANS133LSRRP S YRKIL 35.44%CaMK4 Phospho.ELM 7.0  ViewAnalyzing
16CREB1CREB1_HUMANS133LSRRP S YRKIL 35.44%AKT_group Phospho.ELM 7.0 ViewAnalyzing
17CREB1CREB1_HUMANS133LSRRP S YRKIL 35.44%SGK1 HPRD:00442(in vivo)  ViewAnalyzing
18CREB1CREB1_HUMANS133LSRRP S YRKIL 35.44%p38a(MAPK14) Phospho.ELM 7.0 ViewAnalyzing
19CREB1CREB1_HUMANS133LSRRP S YRKIL 35.44%PKG1 HPRD:00442(in vitro)  ViewAnalyzing
20CREB1CREB1_HUMANS133LSRRP S YRKIL 35.44%CaMK1a Swiss-Prot 55.0   ViewAnalyzing
21CREB1CREB1_HUMANS133LSRRP S YRKIL 35.44%CaMK2_group Swiss-Prot 55.0  ViewAnalyzing
22CREB1CREB1_HUMANS133LSRRP S YRKIL 35.44%CaMK4 Swiss-Prot 55.0   ViewAnalyzing
23CREB1CREB1_HUMANS133LSRRP S YRKIL 35.44%PKA_group Phospho.ELM 7.0 ViewAnalyzing
24CREB1CREB1_HUMANS133LSRRP S YRKIL 35.44%RSK2 Phospho.ELM 7.0  ViewAnalyzing
25CREB1CREB1_HUMANS133LSRRP S YRKIL 35.44%RSK2 HPRD:00442(in vitro;in vivo)  ViewAnalyzing
26CREB1CREB1_HUMANS133LSRRP S YRKIL 35.44%RSK1 HPRD:00442(in vitro;in vivo)  ViewAnalyzing
27CREB1CREB1_HUMANS133LSRRP S YRKIL 35.44%MSK2 HPRD:00442(in vitro)  ViewAnalyzing
28CREB1CREB1_HUMANS133LSRRP S YRKIL 35.44%MAPKAPK2 Phospho.ELM 7.0  ViewAnalyzing
29CREB1CREB1_HUMANS133LSRRP S YRKIL 35.44%MAPKAPK2 HPRD:00442(in vitro)  ViewAnalyzing
30CREB1CREB1_HUMANS133LSRRP S YRKIL 35.44%MSK1 HPRD:00442(in vitro;in vivo)  ViewAnalyzing
31CREB1CREB1_HUMANS133LSRRP S YRKIL 35.44%RSK3 Phospho.ELM 7.0  ViewAnalyzing
32CREB1CREB1_HUMANS133LSRRP S YRKIL 35.44%AKT1 HPRD:00442(in vitro)  ViewAnalyzing
33CREB1CREB1_HUMANS142ILNDL S SDAPG 29.09%CaMK2_group Phospho.ELM 7.0 ViewAnalyzing
34CREB1CREB1_HUMANS142ILNDL S SDAPG 29.09%CaMK2_group  Swiss-Prot 55.0 (Similarity) ViewAnalyzing