|Description: cAMP response element-binding protein (CREB).|
Ensembl ID: ENSG00000118260
UniprotKB/SwissProt: CREB1_HUMAN (P16220)
Function: This protein binds the cAMP response element (CRE), a sequence present in many viral and cellular promoters. CREB stimulates transcription on binding to the CRE. Transciption activation is enhanced by the TORC coactivators which act independently of Ser-133 phosphorylation. Implicated in synchronization of circadian rhythmicity.
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Nucleus.