Regulatory Network in Protein Phosphorylation
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Substrate: DLC1

Description: Rho GTPase-activating protein 7 (Rho-type GTPase-activating protein 7)(Deleted in liver cancer 1 protein) (Dlc-1) (HP protein) (StAR-relatedlipid transfer protein 12) (StARD12) (START domain-containing protein12).

Synonyms: ARHGAP7, KIAA1723, STARD12

Ensembl ID: ENSG00000164741

UniprotKB/SwissProt: RHG07_HUMAN (Q96QB1)

Function: Functions as a GTPase-activating protein specific for Rho and an activator of PLCD1 in vivo and induces morphological changes and detachment through cytoskeletal reorganization (By similarity).

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization: Cytoplasm (Potential).
PDB:2DKY
Protein Domain and Phosphorylation Sites:

The phosphorylated sites of DLC1

No.SubstrateUniProtKB IDPositionPhosphoPeptideSolvent AccessibilityCatalytic kinaseSourceComputational Annotation of Catalytic KinaseInteracting PartnersExpression Analysis
1DLC1RHG07_HUMANS86PHRKR S DDSDE 49.13% Swiss-Prot 55.0 (Similarity)View   
2DLC1RHG07_HUMANS89KRSDD S DEDEP 48.14% Swiss-Prot 55.0 (Similarity)View   
3DLC1RHG07_HUMANS304NSTQT S SSSSQ 20.57% Swiss-Prot 55.0 (Similarity)View   
4DLC1RHG07_HUMANS305STQTS S SSSQS 37.31% Swiss-Prot 55.0 (Similarity)View   
5DLC1RHG07_HUMANS310SSSSQ S ETSSA 44.80% Swiss-Prot 55.0 (Similarity)View   
6DLC1RHG07_HUMANT312SSQSE T SSAVS 32.98% Swiss-Prot 55.0 (Similarity)View   
7DLC1RHG07_HUMANS313SQSET S SAVST 16.55% Swiss-Prot 55.0 (Similarity)View   
8DLC1RHG07_HUMANS317TSSAV S TPSPV 34.03% Swiss-Prot 55.0 (Similarity)View   
9DLC1RHG07_HUMANT318SSAVS T PSPVT 22.61% Swiss-Prot 55.0 (Similarity)View   
10DLC1RHG07_HUMANS327VTRTR S LSACN 26.51%AKT1 HPRD:05035(in vivo)  ViewAnalyzing
11DLC1RHG07_HUMANS329RTRSL S ACNKR 31.83%AKT1 HPRD:05035(in vivo)  ViewAnalyzing
12DLC1RHG07_HUMANS567RLRWH S FQSSH 20.30%AKT1 HPRD:05035(in vivo)  ViewAnalyzing