Regulatory Network in Protein Phosphorylation
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Substrate: EDG1

Description: Sphingosine 1-phosphate receptor Edg-1 (Sphingosine 1-phosphatereceptor 1) (S1P1).

Ensembl ID: ENSG00000170989

UniprotKB/SwissProt: EDG1_HUMAN (P21453)

Function: Receptor for the lysosphingolipid sphingosine 1- phosphate (S1P). S1P is a bioactive lysophospholipid that elicits diverse physiological effect on most types of cells and tissues. This inducible epithelial cell G-protein-coupled receptor may be involved in the processes that regulate the differentiation of endothelial cells. Seems to be coupled to the G(i) subclass of heteromeric G proteins.

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization: Cell membrane; Multi-pass membrane protein.
Protein Domain and Phosphorylation Sites:

The phosphorylated sites of EDG1

No.SubstrateUniProtKB IDPositionPhosphoPeptideSolvent AccessibilityCatalytic kinaseSourceComputational Annotation of Catalytic KinaseInteracting PartnersExpression Analysis
1EDG1EDG1_HUMANT236RSRRL T FRKNI 21.41%AKT1(PKB)  Swiss-Prot 55.0  ViewAnalyzing
2EDG1EDG1_HUMANT236RSRRL T FRKNI 21.41%AKT_group Phospho.ELM 7.0 ViewAnalyzing
3EDG1EDG1_HUMANT236RSRRL T FRKNI 21.41%AKT1 HPRD:03578(in vitro;in vivo)  ViewAnalyzing
4EDG1EDG1_HUMANS352MEFSR S KSDNS 35.00% Swiss-Prot 55.0 (Potential)View