|Description: Histone acetyltransferase p300 (EC 188.8.131.52) (E1A-associated proteinp300).|
Ensembl ID: ENSG00000100393
UniprotKB/SwissProt: EP300_HUMAN (Q09472)
Function: Functions as histone acetyltransferase and regulates transcription via chromatin remodeling. Acetylates all four core histones in nucleosomes. Histone acetylation gives an epigenetic tag for transcriptional activation. Binds to and may be involved in the transforming capacity of the adenovirus E1A protein. Mediates cAMP-gene regulation by binding specifically to phosphorylated CREB protein. In case of HIV-1 infection, it is recruited by the viral protein Tat. Regulates Tat's transactivating activity and may help inducing chromatin remodeling of proviral genes.
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Nucleus.