Regulatory Network in Protein Phosphorylation
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Substrate: EZH2

Description: Enhancer of zeste homolog 2 (ENX-1) (Lysine N-methyltransferase 6).

Synonyms: KMT6

Ensembl ID: ENSG00000106462

UniprotKB/SwissProt: EZH2_HUMAN (Q15910)

Function: May be involved in the regulation of gene transcription and chromatin structure.

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization: Nucleus (Probable).
PDB:2C6V
Protein Domain and Phosphorylation Sites:

The phosphorylated sites of EZH2

No.SubstrateUniProtKB IDPositionPhosphoPeptideSolvent AccessibilityCatalytic kinaseSourceComputational Annotation of Catalytic KinaseInteracting PartnersExpression Analysis
1EZH2EZH2_HUMANS21RKRVK S EYMRL 30.97% Phospho.ELM 7.0View   
2EZH2EZH2_HUMANS21RKRVK S EYMRL 30.97%AKT1 HPRD:03342(in vitro;in vivo)  ViewAnalyzing
3EZH2EZH2_HUMANS380SKDTD S DREAG 40.43% Swiss-Prot 55.0 View   
4EZH2EZH2_HUMANT487AEDVD T PPRKK 34.73% Swiss-Prot 55.0 View   
5EZH2EZH2_HUMANT487AEDVD T PPRKK 34.73% Phospho.ELM 7.0View   
6EZH2EZH2_HUMANT487AEDVD T PPRKK 34.73% HPRD:03342(in vivo)View   
7EZH2EZH2_HUMANT487AEDVD T PPRKK 34.73% HPRD:03342(in vitro;in vivo)View