|Description: Forkhead box protein O3 (Forkhead in rhabdomyosarcoma-like 1) (AF6q21protein).|
Synonyms: FKHRL1, FOXO3A
Ensembl ID: ENSG00000118689
UniprotKB/SwissProt: FOXO3_HUMAN (O43524)
Function: Transcriptional activator which triggers apoptosis in the absence of survival factors, including neuronal cell death upon oxidative stress. Recognizes and binds to the DNA sequence 5'-[AG]TAAA[TC]A-3'.
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Cytoplasm, cytosol. Nucleus. Note=Translocates to the nucleus upon oxidative stress and in the absence of survival factors.