Regulatory Network in Protein Phosphorylation
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Substrate: FOXO3

Description: Forkhead box protein O3 (Forkhead in rhabdomyosarcoma-like 1) (AF6q21protein).

Synonyms: FKHRL1, FOXO3A

Ensembl ID: ENSG00000118689

UniprotKB/SwissProt: FOXO3_HUMAN (O43524)

Function: Transcriptional activator which triggers apoptosis in the absence of survival factors, including neuronal cell death upon oxidative stress. Recognizes and binds to the DNA sequence 5'-[AG]TAAA[TC]A-3'.

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization: Cytoplasm, cytosol. Nucleus. Note=Translocates to the nucleus upon oxidative stress and in the absence of survival factors.
Protein Domain and Phosphorylation Sites:

The phosphorylated sites of FOXO3

No.SubstrateUniProtKB IDPositionPhosphoPeptideSolvent AccessibilityCatalytic kinaseSourceComputational Annotation of Catalytic KinaseInteracting PartnersExpression Analysis
1FOXO3FOXO3_HUMANT32RPRSC T WPLQR 31.22%AKT1 HPRD:04061(in vitro;in vivo)  ViewAnalyzing
2FOXO3FOXO3_HUMANT32RPRSC T WPLQR 31.22%AKT_group Phospho.ELM 7.0 ViewAnalyzing
3FOXO3FOXO3_HUMANT32RPRSC T WPLQR 31.22%AKT1 HPRD:04061(in vitro;in vivo)  ViewAnalyzing
4FOXO3FOXO3_HUMANT32RPRSC T WPLQR 31.22%AKT1(PKB)  Swiss-Prot 55.0  ViewAnalyzing
5FOXO3FOXO3_HUMANT32RPRSC T WPLQR 31.22%SGK1 HPRD:04061(in vitro;in vivo)  ViewAnalyzing
6FOXO3FOXO3_HUMANT32RPRSC T WPLQR 31.22%SGK_group Phospho.ELM 7.0 ViewAnalyzing
7FOXO3FOXO3_HUMANS209AGWKN S IRHNL 19.78%MST1(STK4) Swiss-Prot 55.0  ViewAnalyzing
8FOXO3FOXO3_HUMANS253RRRAV S MDNSN 21.31%AKT_group Phospho.ELM 7.0 ViewAnalyzing
9FOXO3FOXO3_HUMANS253RRRAV S MDNSN 21.31%SGK_group Phospho.ELM 7.0 ViewAnalyzing
10FOXO3FOXO3_HUMANS253RRRAV S MDNSN 21.31%SGK1 HPRD:04061(in vivo)  ViewAnalyzing
11FOXO3FOXO3_HUMANS253RRRAV S MDNSN 21.31%AKT1 HPRD:04061(in vitro;in vivo)  ViewAnalyzing
12FOXO3FOXO3_HUMANS253RRRAV S MDNSN 21.31%AKT1 HPRD:04061(in vitro;in vivo)  ViewAnalyzing
13FOXO3FOXO3_HUMANS253RRRAV S MDNSN 21.31%AKT1(PKB)  Swiss-Prot 55.0  ViewAnalyzing
14FOXO3FOXO3_HUMANS315RSRTN S NASTV 32.91%SGK1 Swiss-Prot 55.0   ViewAnalyzing
15FOXO3FOXO3_HUMANS315RSRTN S NASTV 32.91%SGK_group Phospho.ELM 7.0 ViewAnalyzing
16FOXO3FOXO3_HUMANS315RSRTN S NASTV 32.91%SGK1 HPRD:04061(in vitro;in vivo)  ViewAnalyzing
17FOXO3FOXO3_HUMANS318TNSNA S TVSGR 33.32% Phospho.ELM 7.0View   
18FOXO3FOXO3_HUMANS321NASTV S GRLSP 20.48% Phospho.ELM 7.0View   
19FOXO3FOXO3_HUMANS644DFNFD S LISTQ 24.38%IKKb(IKK beta) Phospho.ELM 7.0 ViewAnalyzing